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Systems Toxicology and the Chemical Effects in Biological Systems ...

By: Michael Waters

Government Reference Publication

Excerpt: The National Center for Toxicogenomics is developing the first public toxicogenomics knowledge base that combines molecular expression data sets from transcriptomics, proteomics, metabonomics, and conventional toxicology with metabolic, toxicological pathway, and gene regulatory network information relevant to environmental toxicology and human disease. It is called the Chemical Effects in Biological Systems (CEBS) knowledge base and is designed to meet the info...

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Formation of the Metalthiolate Clusters of Rat Liver Metallothionein

By: Dennis R. Winge

Government Reference Publication

Excerpt: Metallothionein (MT) induced by Cd or Zn ions binds seven metal ions per molecule, and this chelation involves the cysteines in the ligand field. The metal ions are bound in two separate polynuclear metal-cysteine clusters (1 3) . One cluster (cluster A) contains four metal ions bound to eleven cysteines, five of which exist as thiolate bridges connecting adjacent metal ions. The other center (cluster B) binds three metal ions through nine cysteines and three th...

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Response of Cell Cultures to Asbestos Fibers

By: J. Bruch

Government Reference Publication

Excerpt: I would like to present some results concerning the action of asbestos dust on different cells in vitro. These studies were carried out in our laboratory in collaboration with Prof. Beck and Dr. Manojlovic.

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Considering a Society of Environmental Health Science

By: David A. Schwartz, M. D.

Government Reference Publication

Excerpt: Although it may seem counterintuitive, the more we learn about science, the more complex it becomes. This is particularly true in the field of environmental health science. As the field has evolved, weve come to realize that the environment permeates nearly every question of human disease and that various forms of environmental stress can be used to understand many of the secrets of human biology. And the challenges that lie before us in solving the mysteries of...

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Lmg-Term Observations on Tubular and Girloirular Function in Cadmi...

By: Magnus Piscator

Government Reference Publication

Introduction: The renal dysfunction caused by cadmium is generally regarded as irreversible. Workers from the group originally studied by Friberg (1) in 1946 were subsequently subjected to several reexaminations (2-6). The first follow-up study was carried out by Friberg and Nystrom in 1952 (2). These authors found that the proteinuria in the examined group had not disappeared; on the contrary, they found that proteinuria had developed in some subjects after cessation of...

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