World Library  


 
  • Cover Image

Plos Biology : the Mismeasure of Science ; Stephen Jay Gould Versu...

By: David Degusta
Read More
  • Cover Image

Plos Biology : a Nonparametric Test Reveals Selection for Rapid Fl...

By: Nick Barton

Description : The detection of footprints of natural selection in genetic polymorphism data is fundamental to understanding the genetic basis of adaptation, and has important implications for human health. The standard approach has been to reject neutrality in favor of selection if the pattern of variation at a candidate locus was significantly different from the predictions of the standard neutral model. The problem is that the standard neutral model assumes more than j...

Read More
  • Cover Image

Plos Biology : Fbw7 Repression by Hes5 Creates a Feedback Loop Tha...

By: Raphael Kopan

Description : FBW7 is a crucial component of an SCF-type E3 ubiquitin ligase, which mediates degradation of an array of different target proteins. The Fbw7 locus comprises three different isoforms, each with its own promoter and each suspected to have a distinct set of substrates. Most FBW7 targets have important functions in developmental processes and oncogenesis, including Notch proteins, which are functionally important substrates of SCF(Fbw7). Notch signaling contro...

Read More
  • Cover Image

Plos Biology : Interdependency of Brassinosteroid and Auxin Signal...

By: Jeffrey Dangl

Description : How growth regulators provoke context-specific signals is a fundamental question in developmental biology. In plants, both auxin and brassinosteroids (BRs) promote cell expansion, and it was thought that they activated this process through independent mechanisms. In this work, we describe a shared auxin:BR pathway required for seedling growth. Genetic, physiological, and genomic analyses demonstrate that response from one pathway requires the function of th...

Read More
  • Cover Image

Plos Biology : Sonic Hedgehog Promotes Tumor Cell Survival by Inhi...

By: Matthew P. Scott

Description : The Hedgehog signaling is a determinant pathway for tumor progression. However, while inhibition of the Hedgehog canonical pathway—Patched–Smoothened–Gli—has proved efficient in human tumors with activating mutations in this pathway, recent clinical data have failed to show any benefit in other cancers, even though Sonic Hedgehog (SHH) expression is detected in these cancers. Cell-adhesion molecule-related/down-regulated by Oncogenes (CDON), a positive regu...

Read More
  • Cover Image

Plos Biology : a Large Fraction of Extragenic Rna Pol II Transcrip...

By: John S. Mattick

Description : Mammalian genomes are pervasively transcribed outside mapped protein-coding genes. One class of extragenic transcription products is represented by long non-coding RNAs (lncRNAs), some of which result from Pol_II transcription of bona-fide RNA genes. Whether all lncRNAs described insofar are products of RNA genes, however, is still unclear. Here we have characterized transcription sites located outside protein-coding genes in a highly regulated response, ma...

Read More
  • Cover Image

Plos Biology : a Combinatorial Code for Splicing Silencing ; Uagg ...

By: Phillip D. Zamore

Description : Alternative pre-mRNA splicing is widely used to regulate gene expression by tuning the levels of tissue-specific mRNA isoforms. Few regulatory mechanisms are understood at the level of combinatorial control despite numerous sequences, distinct from splice sites, that have been shown to play roles in splicing enhancement or silencing. Here we use molecular approaches to identify a ternary combination of exonic UAGG and 59-splice-site-proximal GGGG motifs tha...

Read More
  • Cover Image

Plos Biology : Brief Bursts Self-inhibit and Correlate the Pyramid...

By: Alberto Bacci

Description : Inhibitory pathways are an essential component in the function of the neocortical microcircuitry. Despite the relatively small fraction of inhibitory neurons in the neocortex, these neurons are strongly activated due to their high connectivity rate and the intricate manner in which they interconnect with pyramidal cells (PCs). One prominent pathway is the frequencydependent disynaptic inhibition (FDDI) formed between layer 5 PCs and mediated by Martinotti c...

Read More
  • Cover Image

Plos Biology : the “ets” Factor ; Vessel Formation in Zebrafi Sh—t...

By: Lucy J. Patterson
Read More
  • Cover Image

Plos Biology : the Genetics of Brain Wiring ; from Molecule to Min...

By: Kevin J. Mitchell
Read More
  • Cover Image

Plos Biology : Functional Clustering Drives Encoding Improvement i...

By: Christopher C. Pack

Description : Sensory experience drives dramatic structural and functional plasticity in developing neurons. However, for single-neuron plasticity to optimally improve whole-network encoding of sensory information, changes must be coordinated between neurons to ensure a full range of stimuli is efficiently represented. Using two-photon calcium imaging to monitor evoked activity in over 100 neurons simultaneously, we investigate network-level changes in the developing Xen...

Read More
  • Cover Image

Plos Biology : in the Prostate, Volume 1

By: In the Prostate

Description : MicroRNAs (miRNAs) are short RNA molecules that regulate gene expression by binding to target messenger RNAs and by controlling protein production or causing RNA cleavage. To date, functions have been assigned to only a few of the hundreds of identified miRNAs, in part because of the difficulty in identifying their targets. The short length of miRNAs and the fact that their complementarity to target sequences is imperfect mean that target identification in ...

Read More
  • Cover Image

Plos Biology : the Extraordinary Evolutionary History of the Retic...

By: Bill Sugden

Description : The reticuloendotheliosis viruses (REVs) comprise several closely related amphotropic retroviruses isolated from birds. These viruses exhibit several highly unusual characteristics that have not so far been adequately explained, including their extremely close relationship to mammalian retroviruses, and their presence as endogenous sequences within the genomes of certain large DNA viruses. We present evidence for an iatrogenic origin of REVs that accounts f...

Read More
  • Cover Image

Plos Biology : Forest Elephant Crisis in the Congo Basin, Volume 5

By: Georgina M. MacE

Description : Debate over repealing the ivory trade ban dominates conferences of the Convention on International Trade in Endangered Species of Wild Fauna and Flora (CITES). Resolving this controversy requires accurate estimates of elephant population trends and rates of illegal killing. Most African savannah elephant populations are well known: however, the status of forest elephants, perhaps a distinct species, in the vast Congo Basin is unclear. We assessed population...

Read More
  • Cover Image

Plos Biology : Rescue of Progeria in Trichothiodystrophy by Homozy...

By: Edison Liu

Description : Although compound heterozygosity, or the presence of two different mutant alleles of the same gene, is common in human recessive disease, its potential to impact disease outcome has not been well documented. This is most likely because of the inherent difficulty in distinguishing specific biallelic effects from differences in environment or genetic background. We addressed the potential of different recessive alleles to contribute to the enigmatic pleiotrop...

Read More
  • Cover Image

Plos Biology : Recruitment of Cln3 Cyclin to Promoters Controls Ce...

By: Mark Solomon

Description : In yeast, the G1 cyclin Cln3 promotes cell cycle entry by activating the transcription factor SBF. In mammals, there is a parallel system for cell cycle entry in which cyclin dependent kinase (CDK) activates transcription factor E2F/Dp. Here we show that Cln3 regulates SBF by at least two different pathways, one involving the repressive protein Whi5, and the second involving Stb1. The Rpd3 histone deacetylase complex is also involved. Cln3 binds to SBF at t...

Read More
  • Cover Image

Plos Biology : Biodiversity Loss Threatens Human Well-being, Volume 4

By: Sandra Díaz
Read More
  • Cover Image

Plos Biology : a Neutral Model of Transcriptome Evolution, Volume 2

By: David Botstein

Description : Microarray technologies allow the identification of large numbers of expression differences within and between species. Although environmental and physiological stimuli are clearly responsible for changes in the expression levels of many genes, it is not known whether the majority of changes of gene expression fixed during evolution between species and between various tissues within a species are caused by Darwinian selection or by stochastic processes. We ...

Read More
  • Cover Image

Plos Biology : Treatment of Terminal Peritoneal Carcinomatosis by ...

By: Nicholas Hastie

Description : Advanced-stage peritoneal carcinomatosis is resistant to current chemotherapy treatment and, in the case of metastatic ovarian cancer, results in a devastating 15%–20% survival rate. Therapeutics that restore genes inactivated during oncogenesis are predicted to be more potent and specific than current therapies. Experiments with viral vectors have demonstrated the theoretical utility of expressing the p53 tumor suppressor gene in cancer cells. However, cli...

Read More
  • Cover Image

Plos Biology : Biosafety Data as Confidential Business Information...

By: Claire Marris

Description : CBI is a necessary tool to protect commercial interests in the rapidly developing field of genetic engineering. I do not claim that company-sponsored and -conducted research is generally flawed or inferior to other sources of scientific knowledge, but rather challenge current practices and indiscriminate uses of CBI claims. Legitimate CBI claims should be reduced to those with significant commercial justification (Box 1). Moreover, although some regulatory ...

Read More
 
1
|
2
|
3
Records: 1 - 20 of 45 - Pages: 



Copyright © World Library Foundation. All rights reserved. eBooks from World Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.