World Library  


 
  • Cover Image

Plos Biology : Siglec-1 is a Novel Dendritic Cell Receptor That Me...

By: Ueli Grossniklaus

Description : Dendritic cells (DCs) are essential antigen-presenting cells for the induction of immunity against pathogens. However, HIV-1 spread is strongly enhanced in clusters of DCs and CD4+ T cells. Uninfected DCs capture HIV-1 and mediate viral transfer to bystander CD4+ T cells through a process termed trans-infection. Initial studies identified the C-type lectin DC-SIGN as the HIV-1 binding factor on DCs, which interacts with the viral envelope glycoproteins. Upo...

Read More
  • Cover Image

Plos Biology : Nicotine as Therapy, Volume 2

By: Tabitha M. Powledge
Read More
  • Cover Image

Plos Biology : No Place for Predators, Volume 6

By: Liza Gross
Read More
  • Cover Image

Plos Biology : Human Epigenome Project—up and Running, Volume 1

By: Jane Bradbury
Read More
  • Cover Image

Plos Biology : will Ion Channels Help Coccolithophores Adapt to Oc...

By: Public Library of Science (Plos)
Read More
  • Cover Image

Plos Biology : Ubiquitylation in Erad ; Reversing to Go Forward, V...

By: Allan M. Weissman
Read More
  • Cover Image

Plos Biology : Highly Conserved Non-coding Sequences Are Associate...

By: Sean Eddy

Description : In addition to protein coding sequence, the human genome contains a significant amount of regulatory DNA, the identification of which is proving somewhat recalcitrant to both in silico and functional methods. An approach that has been used with some success is comparative sequence analysis, whereby equivalent genomic regions from different organisms are compared in order to identify both similarities and differences. In general, similarities in sequence bet...

Read More
  • Cover Image

Plos Biology : Polarized Secretion of Drosophila Egfr Ligand from ...

By: Konrad Basler

Description : The release of signaling molecules from neurons must be regulated, to accommodate their highly polarized structure. In the developing Drosophila visual system, photoreceptor neurons secrete the epidermal growth factor receptor ligand Spitz (Spi) from their cell bodies, as well as from their axonal termini. Here we show that subcellular localization of Rhomboid proteases, which process Spi, determines the site of Spi release from neurons. Endoplasmic reticul...

Read More
  • Cover Image

Plos Biology : when Bacteria Lose a Single Dna Base, Aphids Suff E...

By: Mary Hoff
Read More
  • Cover Image

Plos Biology : Cftr Delivery to 25% of Surface Epithelial Cells Re...

By: Lennart Philipson

Description : Dysfunction of CFTR in cystic fibrosis (CF) airway epithelium perturbs the normal regulation of ion transport, leading to a reduced volume of airway surface liquid (ASL), mucus dehydration, decreased mucus transport, and mucus plugging of the airways. CFTR is normally expressed in ciliated epithelial cells of the surface and submucosal gland ductal epithelium and submucosal gland acinar cells. Critical questions for the development of gene transfer strategi...

Read More
  • Cover Image

Plos Biology : Ghost Bird – the Ivory-billed Woodpecker ; Hopes, D...

By: Jerome A. Jackson
Read More
  • Cover Image

Plos Biology : a Mitotic Phosphorylation Feedback Network Connects...

By: Michael Lichten

Description : DNA damage checkpoints arrest cell cycle progression to facilitate DNA repair. The ability to survive genotoxic insults depends not only on the initiation of cell cycle checkpoints but also on checkpoint maintenance. While activation of DNA damage checkpoints has been studied extensively, molecular mechanisms involved in sustaining and ultimately inactivating cell cycle checkpoints are largely unknown. Here, we explored feedback mechanisms that control the ...

Read More
  • Cover Image

Plos Biology : Dna-dependent Protein Kinase Inhibits Aidinduced An...

By: David Nemazee

Description : Affinity maturation and class switching of antibodies requires activation-induced cytidine deaminase (AID)-dependent hypermutation of Ig V(D)J rearrangements and Ig S regions, respectively, in activated B cells. AID deaminates deoxycytidine bases in Ig genes, converting them into deoxyuridines. In V(D)J regions, subsequent excision of the deaminated bases by uracil-DNA glycosylase, or by mismatch repair, leads to further point mutation or gene conversion, d...

Read More
  • Cover Image

Plos Biology : Limbs Made to Measure, Volume 8

By: Anna Kicheva
Read More
  • Cover Image

Plos Biology : You Aren’t Always What You Eat, Volume 8

By: Robin Meadows
Read More
  • Cover Image

Plos Biology : the Alarming Proximity of Parasites, Volume 8

By: Frédéric Thomas
Read More
  • Cover Image

Plos Biology : Primary Visual Cortex Activity Along the Apparent-m...

By: Robert Zatorre

Description : The illusion of apparent motion can be induced when visual stimuli are successively presented at different locations. It has been shown in previous studies that motion-sensitive regions in extrastriate cortex are relevant for the processing of apparent motion, but it is unclear whether primary visual cortex (V1) is also involved in the representation of the illusory motion path. We investigated, in human subjects, apparent-motion-related activity in patches...

Read More
  • Cover Image

Plos Biology : the Brct Domain of Parp-1 is Required for Immunoglo...

By: David Nemazee

Description : Genetic variation at immunoglobulin (Ig) gene variable regions in B-cells is created through a multi-step process involving deamination of cytosine bases by activation-induced cytidine deaminase (AID) and their subsequent mutagenic repair. To protect the genome from dangerous, potentially oncogenic effects of off-target mutations, both AID activity and mutagenic repair are targeted specifically to the Ig genes. However, the mechanisms of targeting are unkno...

Read More
  • Cover Image

Plos Biology : Integration of Canonical and Noncanonical Wnt Signa...

By: Christof Niehrs

Description : Patterning the neuroectoderm along the anterior–posterior (AP) axis is a critical event in the early development of deuterostome embryos. However, the mechanisms that regulate the specification and patterning of the neuroectoderm are incompletely understood. Remarkably, the anterior neuroectoderm (ANE) of the deuterostome sea urchin embryo expresses many of the same transcription factors and secreted modulators of Wnt signaling, as does the early vertebrate...

Read More
  • Cover Image

Plos Biology : Polymorphic Cis- and Trans-regulation of Human Gene...

By: Jonathan Flint

Description : Expression levels of human genes vary extensively among individuals. This variation facilitates analyses of expression levels as quantitative phenotypes in genetic studies where the entire genome can be scanned for regulators without prior knowledge of the regulatory mechanisms, thus enabling the identification of unknown regulatory relationships. Here, we carried out such genetic analyses with a large sample size and identified cis- and trans-acting polymo...

Read More
 
1
|
2
|
3
Records: 1 - 20 of 45 - Pages: 



Copyright © World Library Foundation. All rights reserved. eBooks from World Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.