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Plos Biology : Independent Regulation of Basal Neurotransmitter Re...

By: Gareth E. Jones

Description : The efficacy of action potential evoked neurotransmitter release varies widely even among synapses supplied by the same axon, and the number of release-ready vesicles at each synapse is a major determinant of this heterogeneity. Here we identify a second, equally important, mechanism for release heterogeneity at small hippocampal synapses, the intersynaptic variation of the exocytosis probability of release-ready vesicles. Using concurrent measurements of v...

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Plos Biology : Eco-defense Against Invasions, Volume 3

By: Virginia Gewin
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Plos Biology : Surviving Endoplasmic Reticulum Stress is Coupled t...

By: Marianne Bronner-fraser

Description : In protein folding and secretion disorders, activation of endoplasmic reticulum (ER) stress signaling (ERSS) protects cells, alleviating stress that would otherwise trigger apoptosis. Whether the stress-surviving cells resume normal function is not known. We studied the in vivo impact of ER stress in terminally differentiating hypertrophic chondrocytes (HCs) during endochondral bone formation. In transgenic mice expressing mutant collagen X as a consequence...

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Plos Biology : Open Access ; a Plos for Education, Volume 2

By: A. Malcolm Campbell
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Plos Biology : a Fishy Way to Discuss Multiple Genes Affecting the...

By: Cheryl A. Kerfeld
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