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Plos Biology : Small Heat Shock Proteins Potentiate Amyloid Dissol...

By: Ueli Schibler

Description : How small heat shock proteins (sHsps) might empower proteostasis networks to control beneficial prions or disassemble pathological amyloid is unknown. Here, we establish that yeast sHsps, Hsp26 and Hsp42, inhibit prionogenesis by the [PSI+] prion protein, Sup35, via distinct and synergistic mechanisms. Hsp42 prevents conformational rearrangements within molten oligomers that enable de novo prionogenesis and collaborates with Hsp70 to attenuate self-templati...

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Plos Biology : Facilitation of Ampa Receptor Synaptic Delivery as ...

By: Peter Scheiffele

Description : Cell adhesion molecules and downstream growth factor-dependent signaling are critical for brain development and synaptic plasticity, and they have been linked to cognitive function in adult animals. We have previously developed a mimetic peptide (FGL) from the neural cell adhesion molecule (NCAM) that enhances spatial learning and memory in rats. We have now investigated the cellular and molecular basis of this cognitive enhancement, using biochemical, morp...

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Plos Biology : Capzb2 Interacts with B-tubulin to Regulate Growth ...

By: Manfred Schliwa

Description : Capping protein (CP) is a heterodimer that regulates actin assembly by binding to the barbed end of F-actin. In cultured nonneuronal cells, each CP subunit plays a critical role in the organization and dynamics of lamellipodia and filopodia. Mutations in either a or b CP subunit result in retinal degeneration in Drosophila. However, the function of CP subunits in mammalian neurons remains unclear. Here, we investigate the role of the b CP subunit expressed ...

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Plos Biology : Ghost Bird – the Ivory-billed Woodpecker ; Hopes, D...

By: Jerome A. Jackson
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Plos Biology : Resolving Difficult Phylogenetic Questions ; Why Mo...

By: David Penny
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Plos Biology : Treatment of Terminal Peritoneal Carcinomatosis by ...

By: Nicholas Hastie

Description : Advanced-stage peritoneal carcinomatosis is resistant to current chemotherapy treatment and, in the case of metastatic ovarian cancer, results in a devastating 15%–20% survival rate. Therapeutics that restore genes inactivated during oncogenesis are predicted to be more potent and specific than current therapies. Experiments with viral vectors have demonstrated the theoretical utility of expressing the p53 tumor suppressor gene in cancer cells. However, cli...

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Plos Biology : Network Hubs Buffer Environmental Variation in Sacc...

By: Sasha F. Levy

Description : Regulatory and developmental systems produce phenotypes that are robust to environmental and genetic variation. A gene product that normally contributes to this robustness is termed a phenotypic capacitor. When a phenotypic capacitor fails, for example when challenged by a harsh environment or mutation, the system becomes less robust and thus produces greater phenotypic variation. A functional phenotypic capacitor provides a mechanism by which hidden polymo...

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Plos Biology : in Silico Reconstitution of Actin-based Symmetry Br...

By: Thomas Pollard

Description : Eukaryotic cells assemble viscoelastic networks of crosslinked actin filaments to control their shape, mechanical properties, and motility. One important class of actin network is nucleated by the Arp2/3 complex and drives both membrane protrusion at the leading edge of motile cells and intracellular motility of pathogens such as Listeria monocytogenes. These networks can be reconstituted in vitro from purified components to drive the motility of spherical ...

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Plos Biology : a Hymn to Neurosurgery and Neuroscience, Volume 3

By: Richard Smith
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Plos Biology : Not All Genes Are Equal; Shortage of Histones Affec...

By: Public Library of Science (Plos)
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Plos Biology : Ecology’s Big, Hot Idea, Volume 2

By: John Whitfield
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Plos Biology : Ubiquitylation in Erad ; Reversing to Go Forward, V...

By: Allan M. Weissman
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Plos Biology : the Temporal Requirements for Insulin Signaling Dur...

By: Laura Johnston

Description : Recent studies have indicated that the insulin-signaling pathway controls body and organ size in Drosophila, and most metazoans, by signaling nutritional conditions to the growing organs. The temporal requirements for insulin signaling during development are, however, unknown. Using a temperature-sensitive insulin receptor (Inr) mutation in Drosophila, we show that the developmental requirements for Inr activity are organ specific and vary in time. Early in...

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Plos Biology : Two Distinct E3 Ubiquitin Ligases Have Complementar...

By: Alfonso Martinez Arias

Description : Signaling by the Notch ligands Delta (Dl) and Serrate (Ser) regulates a wide variety of essential cell-fate decisions during animal development. Two distinct E3 ubiquitin ligases, Neuralized (Neur) and Mind bomb (Mib), have been shown to regulate Dl signaling in Drosophila melanogaster and Danio rerio, respectively. While the neur and mib genes are evolutionarily conserved, their respective roles in the context of a single organism have not yet been examine...

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Plos Biology : a Shortcut to Immortality ; Rapid Reprogramming wit...

By: Liza Gross
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Plos Biology : Gal4 Gets Genes to Loosen Up, Volume 6

By: Caitlin Sedwick
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Plos Biology : in Plos Biology, Volume 3, Issue 4, Volume 3

By: Liza Gross
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Plos Biology : Three-dimensional Reconstruction of Bacteria with a...

By: Jonathan A. Eisen

Description : The division of cellular space into functionally distinct membrane-defined compartments has been one of the major transitions in the history of life. Such compartmentalization has been claimed to occur in members of the Planctomycetes, Verrucomicrobiae, and Chlamydiae bacterial superphylum. Here we have investigated the three-dimensional organization of the complex endomembrane system in the planctomycete bacteria Gemmata obscuriglobus. We reveal that the G...

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Plos Biology : Novel Role of Nox in Supporting Aerobic Glycolysis ...

By: Manfred Schartl

Description : Elevated aerobic glycolysis in cancer cells (the Warburg effect) may be attributed to respiration injury or mitochondrial dysfunction, but the underlying mechanisms and therapeutic significance remain elusive. Here we report that induction of mitochondrial respiratory defect by tetracycline-controlled expression of a dominant negative form of DNA polymerase c causes a metabolic shift from oxidative phosphorylation to glycolysis and increases ROS generation....

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Plos Biology : Expressing the Big Picture, Volume 3

By: Hemai Parthasarathy
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