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Plos Biology : Seeking Membranes ; Positive-strand Rnavirus Replic...

By: Mark R. Denison
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Plos Biology : Enhanced Odor Discrimination and Impaired Olfactory...

By: Howard Eichenbaum

Description : Genetic perturbations of a-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors (AMPARs) are widely used to dissect molecular mechanisms of sensory coding, learning, and memory. In this study, we investigated the role of Ca2þpermeable AMPARs in olfactory behavior. AMPAR modification was obtained by depletion of the GluR-B subunit or expression of unedited GluR-B(Q), both leading to increased Ca2þ permeability of AMPARs. Mice with this functional AMPAR s...

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Plos Biology : Premitotic Assembly of Human Cenps -t and -w Switch...

By: Don Cleveland

Description : Centromeres are differentiated chromatin domains, present once per chromosome, that direct segregation of the genome in mitosis and meiosis by specifying assembly of the kinetochore. They are distinct genetic loci in that their identity in most organisms is determined not by the DNA sequences they are associated with, but through specific chromatin composition and context. The core nucleosomal protein CENP-A/cenH3 plays a primary role in centromere determin...

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Plos Biology : Iron Regulation of the Major Virulence Factors in t...

By: Joseph Heitman

Description : Iron overload is known to exacerbate many infectious diseases, and conversely, iron withholding is an important defense strategy for mammalian hosts. Iron is a critical cue for Cryptococcus neoformans because the fungus senses iron to regulate elaboration of the polysaccharide capsule that is the major virulence factor during infection. Excess iron exacerbates experimental cryptococcosis and the prevalence of this disease in Sub-Saharan Africa has been asso...

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Plos Biology : Molecular Remodeling of Tip Links Underlies Mechano...

By: Walter Marcotti

Description : Sound detection by inner ear hair cells requires tip links that interconnect mechanosensory stereo cilia and convey force to yet unidentified transduction channels. Current models postulate a static composition of the tip link, with protocadherin 15 (PCDH15) at the lower and cadherin 23 (CDH23) at the upper end of the link. In terminally differentiated mammalian auditory hair cells, tip links are subjected to sound-induced forces throughout an organism’s li...

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