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Plos Biology : Parallel Chemical Genetic and Genome-wide Rnai Scre...

By: Gerald Joyce

Description : Cytokinesis involves temporally and spatially coordinated action of the cell cycle and cytoskeletal and membrane systems to achieve separation of daughter cells. To dissect cytokinesis mechanisms it would be useful to have a complete catalog of the proteins involved, and small molecule tools for specifically inhibiting them with tight temporal control. Finding active small molecules by cell-based screening entails the difficult step of identifying their tar...

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Plos Biology : the Impact of the Species–area Relationship on Esti...

By: Simon Levin

Description : Estimates of paleodiversity patterns through time have relied on datasets that lump taxonomic occurrences from geographic areas of varying size per interval of time. In essence, such estimates assume that the species–area effect, whereby more species are recorded from larger geographic areas, is negligible for fossil data. We tested this assumption by using the newly developed Miocene Mammal Mapping Project database of western North American fossil mammals ...

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Plos Biology : Shavenbaby Couples Patterning to Epidermal Cell Sha...

By: Alfonso Martinez

Description : It is well established that developmental programs act during embryogenesis to determine animal morphogenesis. How these developmental cues produce specific cell shape during morphogenesis, however, has remained elusive. We addressed this question by studying the morphological differentiation of the Drosophila epidermis, governed by a well-known circuit of regulators leading to a stereotyped pattern of smooth cells and cells forming actin-rich extensions (t...

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Plos Biology : There Goes the Gene Expression Neighbourhood Theory...

By: Rachel Jones
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Plos Biology : Securin is Not Required for Chromosomal Stability i...

By: R. Scott Hawley

Description : Abnormalities of chromosome number are frequently observed in cancers. The mechanisms regulating chromosome segregation in human cells are therefore of great interest. Recently it has been reported that human cells without an hSecurin gene lose chromosomes at a high frequency. Here we show that, after hSecurin knockout through homologous recombination, chromosome losses are only a short, transient effect. After a few passages hSecurin / cells became chromos...

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