World Library  


 
  • Cover Image

Plos One : Inferring Multiple Refugia and Phylogeographical Patter...

By: Dmitry A. Filatov

Description : Background : Pinus massoniana, an ecologically and economically important conifer, is widespread across central and southern mainland China and Taiwan. In this study, we tested the central–marginal paradigm that predicts that the marginal populations tend to be less polymorphic than the central ones in their genetic composition, and examined a founders’ effect in the island population. Methodology/Principal Findings : We examined the phylogeography and popu...

Read More
  • Cover Image

Plos One : Characterization of Fkgk18 as Inhibitor of Group Via CA...

By: Bridget Wagner

Description : Ongoing studies suggest an important role for iPLA2b in a multitude of biological processes and it has been implicated in neurodegenerative, skeletal and vascular smooth muscle disorders, bone formation, and cardiac arrhythmias. Thus, identifying an iPLA2binhibitor that can be reliably and safely used in vivo is warranted. Currently, the mechanism-based inhibitor bromoenol lactone (BEL) is the most widely used to discern the role of iPLA2b in biological pro...

Read More
  • Cover Image

Plos One : Evolution of the R2 Retrotransposon Ribozyme and Its Se...

By: Mark a Batzer

Description : R2 is a non-long terminal repeat retrotransposon that inserts site-specifically in the tandem 28S rRNA genes of many animals. Previously, R2 RNA from various species of Drosophila was shown to self-cleave from the 28S rRNA/R2 cotranscript by a hepatitis D virus (HDV)-like ribozyme encoded at its 5' end. RNA cleavage was at the precise 5' junction of the element with the 28S gene. Here we report that RNAs encompassing the 5' ends of R2 elements from througho...

Read More
  • Cover Image

Plos One : Growth Associated Protein 43 is Expressed in Skeletal M...

By: Petras Dzeja

Description : The neuronal Growth Associated Protein 43 (GAP43), also known as B-50 or neuromodulin, is involved in mechanisms controlling pathfinding and branching of neurons during development and regeneration. For many years this protein was classified as neuron-specific, but recent evidences suggest that a) GAP43 is expressed in the nervous system not only in neurons, but also in glial cells, and b) probably it is present also in other tissues. In particular, its exp...

Read More
  • Cover Image

Plos One : Angiotensin II Reduces Cardiac Adipor1 Expression Throu...

By: Qingbo Xu

Description : Adiponectin, an abundant adipose tissue-derived protein, exerts protective effect against cardiovascular disease. Adiponectin receptors (AdipoR1 and AdipoR2) mediate the beneficial effects of adiponectin on the cardiovascular system. However, the alteration of AdipoRs in cardiac remodeling is not fully elucidated. Here, we investigated the effect of angiotensin II (AngII) on cardiac AdipoRs expression and explored the possible molecular mechanism. AngII inf...

Read More
  • Cover Image

Plos One : Connective Tissue Fibroblast Properties Are Position- D...

By: Atsushi Asakura

Description : A key factor that contributes to the regenerative ability of regeneration-competent animals such as the salamander is their use of innate positional cues that guide the regeneration process. The limbs of mammals has severe regenerative limitations, however the distal most portion of the terminal phalange is regeneration competent. This regenerative ability of the adult mouse digit is level dependent : amputation through the distal half of the terminal phala...

Read More
  • Cover Image

Plos One : Kdna Genetic Signatures Obtained by Lssp-pcr Analysis o...

By: Rudy A. Hartskeerl

Description : Background : Visceral Leishmaniasis (VL) caused by species from the Leishmania donovani complex is the most severe form of the disease, lethal if untreated. VL caused by Leishmania infantum is a zoonosis with an increasing number of human cases and millions of dogs infected in the Old and the New World. In this study, L. infantum (syn. L.chagasi) strains were isolated from human and canine VL cases. The strains were obtained from endemic areas from Brazil a...

Read More
  • Cover Image

Plos One : Reduced Estradiol-induced Vasodilation and Poly-adpribo...

By: Christopher Torrens

Description : Polycystic ovary syndrome (PCOS) is a complex endocrine disorder characterized by hyperandrogenism and insulin resistance, both of which have been connected to atherosclerosis. Indeed, an increased risk of clinical manifestations of arterial vascular diseases has been described in PCOS. On the other hand endothelial dysfunction can be detected early on, before atherosclerosis develops. Thus we assumed that vascular dysfunction is also related directly to th...

Read More
  • Cover Image

Plos One : Exposure to Bacterial Signals Does Not Alter Pea Aphids...

By: François Leulier

Description : Pea aphids have an obligate nutritional symbiosis with the bacteria Buchnera aphidicola and frequently also harbor one or more facultative symbionts. Aphids are also susceptible to bacterial pathogen infections, and it has been suggested that aphids have a limited immune response towards such pathogen infections compared to other, more well-studied insects. However, aphids do possess at least some of the genes known to be involved in bacterial immune respon...

Read More
  • Cover Image

Plos One : Recognition of Membrane-bound Fusion-peptide, Volume 7

By: Stefan Pöhlmann

Description : The membrane proximal external region (MPER) of the fusogenic HIV-1 glycoprotein-41 harbors the epitope sequence recognized by 2F5, a broadly neutralizing antibody isolated from an infected individual. Structural mimicry of the conserved MPER 2F5 epitope constitutes a pursued goal in the field of anti-HIV vaccine development. It has been proposed that 2F5 epitope folding into its native state is attained in the vicinity of the membrane interface and might i...

Read More
  • Cover Image

Plos One : Efficacy and Safety of Telavancin in Clinical Trials ; ...

By: Brad Spellberg

Description : Introduction : The epidemiology and antibiotic resistance of Staphylococcus aureus have evolved, underscoring the need for novel antibiotics, particularly against methicillin-resistant S. aureus (MRSA). Telavancin is a bactericidal lipoglycopeptide with potent activity against Gram-positive pathogens. Objective : To systematically review and synthesize the available evidence from randomized controlled trials (RCTs) evaluating telavancin in the treatment of ...

Read More
  • Cover Image

Plos One : Tacc3 is Essential for Egf-mediated Emt in Cervical Can...

By: Antimo Migliaccio

Description : The third member of transforming acidic coiled-coil protein (TACC) family, TACC3, has been shown to be an important player in the regulation of centrosome/microtubule dynamics during mitosis and found to be deregulated in a variety of human malignancies. Our previous studies have suggested that TACC3 may be involved in cervical cancer progression and chemoresistance, and its overexpression can induce epithelial-mesenchymal transition (EMT) by activating the...

Read More
  • Cover Image

Plos One : Evaluation of Environmental Safety Concentrations of Dm...

By: Shu-min Duan

Description : Dimercaptosuccinic acid (DMSA) coating improves the uptake efficiency presumably by engendering the Fe2O3-NPs. In the present study, we investigated the possible environmental safety concentrations of Fe2O3-NPs using different assay systems in nematode Caenorhabditis elegans with lethality, development, reproduction, locomotion behavior, pharyngeal pumping, defecation, intestinal autofluorescence and reactive oxygen species (ROS) production as the endpoints...

Read More
  • Cover Image

Plos One : Prenatal Vitamin D Supplementation and Child Respirator...

By: Heinz Fehrenbach

Description : Prenatal vitamin D supplementation in late pregnancy that had a modest effect on cord blood vitamin D level, was not associated with decreased wheezing in offspring at age three years.

Read More
  • Cover Image

Plos One : Present Spatial Diversity Patterns of Theobroma Cacao L...

By: Dorian Q. Fuller

Description : Cacao (Theobroma cacao L.) is indigenous to the Amazon basin, but is generally believed to have been domesticated in Mesoamerica for the production of chocolate beverage. However, cacao’s distribution of genetic diversity in South America is also likely to reflect pre-Columbian human influences that were superimposed on natural processes of genetic differentiation. Here we present the results of a spatial analysis of the intra-specific diversity of cacao in...

Read More
  • Cover Image

Plos One : Overexpression of Orca3 and G10H in Catharanthus Roseus...

By: Leandro Peña

Description : In order to improve the production of the anticancer dimeric indole alkaloids in Catharanthuse roseus, much research has been dedicated to culturing cell lines, hairy roots, and efforts to elucidate the regulation of the monoterpenoid indole alkaloid (MIA) biosynthesis. In this study, the ORCA3 (Octadecanoid-derivative Responsive Catharanthus AP2-domain) gene alone or integrated with the G10H (geraniol 10-hydroxylase) gene were first introduced into C. rose...

Read More
  • Cover Image

Plos One : Differential Phosphorylation of Perilipin 1A at the Ini...

By: Sally Martin

Description : Lipolysis in adipocytes is regulated by phosphorylation of lipid droplet-associated proteins, including perilipin 1A and hormone-sensitive lipase (HSL). Perilipin 1A is potentially phosphorylated by cAMP(adenosine 39,59-cyclic monophosphate)- dependent protein kinase (PKA) on several sites, including conserved C-terminal residues, serine 497 (PKA-site 5) and serine 522 (PKA-site 6). To characterize perilipin 1A phosphorylation, novel monoclonal antibodies w...

Read More
  • Cover Image

Plos One : in Vitro Phosphorylation and Acetylation of the Murine ...

By: Wei-guo Zhu

Description : The retinoblastoma protein (pRb) and the related proteins Rb2/p130 and 107 represent the ‘‘pocket protein’’ family of cell cycle regulators. A key function of these proteins is the cell cycle dependent modulation of E2F-regulated genes. The biological activity of these proteins is controlled by acetylation and phosphorylation in a cell cycle dependent manner. In this study we attempted to investigate the interdependence of acetylation and phosphorylation of...

Read More
  • Cover Image

Plos One : Urogenital Chlamydia Trachomatis Infections Among Ethni...

By: Deborah Dean

Description : Chlamydia prevalence in Suriname is high and targeted prevention measures are required. Although ethnic sexual mixing differed between ethnic groups, differences in prevalence between ethnic groups could not be explained by sexual mixing.

Read More
  • Cover Image

Plos One : Automatic Ability Attribution After Failure ; a Dual Pr...

By: Alessio Avenanti

Description : Causal attribution has been one of the most influential frameworks in the literature of achievement motivation, but previous studies considered achievement attribution as relatively deliberate and effortful processes. In the current study, we tested the hypothesis that people automatically attribute their achievement failure to their ability, but reduce the ability attribution in a controlled manner. To address this hypothesis, we measured participants’ cau...

Read More
 
1
|
2
|
3
Records: 1 - 20 of 45 - Pages: 



Copyright © World Library Foundation. All rights reserved. eBooks from World Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.