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Plos One : Effects of Dominance and Diversity on Productivity Alon...

By: Adam Siepielski

Description : Heinz Ellenberg’s historically important work on changes in the abundances of a community of grass species growing along experimental gradients of water table depth has played an important role in helping to identify the hydrological niches of plant species in wet meadows. We present a previously unpublished complete version of Ellenberg’s dataset from the 1950s together with the results of a series of modern statistical analyses testing for hypothesized ov...

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Plos One : Decision Support System for the Response to Infectious ...

By: Vittoria Colizza
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Plos One : the Rs1024611 Regulatory Region Polymorphism is Associa...

By: Stephen L. Nishimura

Description : CC chemokine ligand 2 (CCL2) is the most potent monocyte chemoattractant and inter-individual differences in its expression level have been associated with genetic variants mapping to the cis-regulatory regions of the gene. An A to G polymorphism in the CCL2 enhancer region at position –2578 (rs1024611: A.G), was found in most studies to be associated with higher serum CCL2 levels and increased susceptibility to a variety of diseases such as HIV-1 associate...

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Plos One : Coastal Bacterioplankton Community Dynamics in Response...

By: David L Kirchman

Description : In order to characterize how disturbances to microbial communities are propagated over temporal and spatial scales in aquatic environments, the dynamics of bacterial assemblages throughout a subtropical coastal embayment were investigated via SSU rRNA gene analyses over an 8-month period, which encompassed a large storm event. During nonperturbed conditions, sampling sites clustered into three groups based on their microbial community composition : an offsh...

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Plos One : Evaluating Methods for Isolating Total Rna and Predicti...

By: Christopher Quince

Description : Next-generation sequencing plays a central role in the characterization and quantification of transcriptomes. Although numerous metrics are purported to quantify the quality of RNA, there have been no large-scale empirical evaluations of the major determinants of sequencing success. We used a combination of existing and newly developed methods to isolate total RNA from 1115 samples from 695 plant species in 324 families, which represents .900 million years ...

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Plos One : Negative Correlation of Liv-1 and E-cadherin Expression...

By: Xin-yuan Guan

Description : LIV-1, a zinc transporter, is a mediator downstream of STAT3 both in zebrafish and mammalian cells, and is involved in epithelial-mesenchymal transition (EMT). Despite LIV-1 participates in cancer growth and metastasis, little is known about the association of LIV-1 with human liver cancer development. Therefore, the expression of LIV-1 mRNA was analyzed by reverse transcriptase polymerase chain reaction (RT-PCR) in 4 cultured cell lines (3 carcinoma and 1 ...

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Plos One : Evaluation of New Reference Genes in Papaya for Accurat...

By: Sung-hwan Yun

Description : Real-time reverse transcription PCR (RT-qPCR) is a preferred method for rapid and accurate quantification of gene expression studies. Appropriate application of RT-qPCR requires accurate normalization though the use of reference genes. As no single reference gene is universally suitable for all experiments, thus reference gene(s) validation under different experimental conditions is crucial for RT-qPCR analysis. To date, only a few studies on reference gene...

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Plos One : the Latest Succession of Dinosaur Tracksites in Europe ...

By: Richard J Butler

Description : A comprehensive review and study of the rich dinosaur track record of the Tremp Formation in the southern Pyrenees of Spain (Southwestern Europe) shows a unique succession of footprint localities prior to the end-Cretaceous mass extinction event. A description of some 30 new tracksites and data on sedimentary environments, track occurrence and preservation, ichnology and chronostratigraphy are provided. These new track localities represent various facies ty...

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Plos One : a 2-year Field Study Shows Little Evidence That the Lon...

By: Nicolas Desneux

Description : Transgenic insect-resistant cotton has been released into the environment for more than a decade in China to effectively control the cotton bollworm (Helicoverpa armigera) and other Lepidoptera. Because of concerns about undesirable ecological side-effects of transgenic crops, it is important to monitor the potential environmental impact of transgenic insect-resistant cotton after commercial release. Our 2-year study included 1 cotton field where non-transg...

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Plos One : Label-free Evaluation of Hepatic Microvesicular Steatos...

By: Wendong Huang

Description : Hepatic microvesicular steatosis is a hallmark of drug-induced hepatotoxicity and early-stage fatty liver disease. Current histopathology techniques are inadequate for the clinical evaluation of hepatic microvesicular steatosis. In this paper, we explore the use of multimodal coherent anti-Stokes Raman scattering (CARS) microscopy for the detection and characterization of hepatic microvesicular steatosis. We show that CARS microscopy is more sensitive than ...

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Plos One : Serum Gp73, a Marker for Evaluating Progression in Pati...

By: Sang-hoon Ahn

Description : This study was designed to investigate the role of serum GP73 for diagnosing significant fibrosis in patients with chronic hepatitis B virus (HBV) infections. Two populations were enrollment. All subjects were patients with chronic HBV infections. First population included 761 patients, who received liver stiffness measurement: the second population included 633 patients, who undertaken liver biopsy, in which 472 patients with nearly normal ALT. All patient...

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Plos One : Seed Structure Characteristics to Form Ultrahigh Oil Co...

By: Meng-xiang Sun

Description : Our results indicate that the oil content of YN171 could be enhanced by increasing the oil body organelle to cell ratio for some cell types. The oil body organelle to seed ratio significantly highly positively correlates with oil content, and could be used to predict seed oil content. Based on the structural analysis of different oil content rapeseed lines, we estimate the maximum of rapeseed oil content could reach 75%. Our results will help us to screen a...

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Plos One : Intravitreal Administration of Ha-1077, a Rock Inhibito...

By: Yoshitaka Nagai

Description : Huntington disease (HD) is an inherited neurodegenerative disease that affects multiple brain regions. It is caused by an expanded polyglutamine tract in huntingtin (Htt). The development of therapies for HD and other neurodegenerative diseases has been hampered by multiple factors, including the lack of clear therapeutic targets, and the cost and complexity of testing lead compounds in vivo. The R6/2 HD mouse model is widely used for pre-clinical trials be...

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Plos One : Cell-to-cell Transmission Can Overcome Multiple Donor a...

By: Fabrizio Mammano

Description : Virus transmission can occur either by a cell-free mode through the extracellular space or by cell-to-cell transmission involving direct cell-to-cell contact. The factors that determine whether a virus spreads by either pathway are poorly understood. Here, we assessed the relative contribution of cell-free and cell-to-cell transmission to the spreading of the human immunodeficiency virus (HIV). We demonstrate that HIV can spread by a cell-free pathway if al...

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Plos One : Non-invasive Detection of Coronary Endothelial Response...

By: Gerard Pasterkamp

Description : MRI measures of CorEndoFx are unchanged during repeated isometric handgrip exercise tests in CAD patients and healthy adults. These findings demonstrate the repeatability of noninvasive 3T MRI assessment of CorEndoFx and support its use in future studies designed to determine the effects of acute interventions on coronary vasoreactivity.

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Plos One : Prediction of Protein-destabilizing Polymorphisms by Ma...

By: Vladimir N. Uversky

Description : The relationship between sequence polymorphisms and human disease has been studied mostly in terms of effects of single nucleotide polymorphisms (SNPs) leading to single amino acid substitutions that change protein structure and function. However, less attention has been paid to more drastic sequence polymorphisms which cause premature termination of a protein’s sequence or large changes, insertions, or deletions in the sequence. We have analyzed a large se...

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Plos One : Phylogenetic and Phylodynamic Analyses of Human Metapne...

By: Patricia V. Aguilar

Description : Human metapneumovirus, which belongs to the Paramyxoviridae family and has been classified as a member of the Pneumovirus genus, is genetically and clinically similar to other family members such as human respiratory syncytial virus. A total of 1146 nasopharyngeal aspirates from pediatric patients with moderate and severe acute lower respiratory tract infections, hospitalized at the Ricardo Gutierrez Childrens Hospital (Buenos Aires, Argentina), were tested...

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Plos One : Risk Factors for Acute Endophthalmitis Following Catara...

By: Demetrios Vavvas

Description : Our study provides summary data on the risk factors for acute POE. Identifying patients at high risk of this sight-threatening eye disease is important from both the public health and clinical perspectives as this would facilitate detection of disease before the onset of irreversible visual loss enabling earlier intervention.

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Plos One : Anthrax Lethal Toxin Downregulates Claudin-5 Expression...

By: Johanna M. Brandner

Description : Vascular leakage pathologies such as pleural effusion and hemorrhage are hallmarks of anthrax pathogenesis. We previously reported that anthrax lethal toxin (LT), the major virulence factor of anthrax, reduces barrier function in cultured primary human microvascular endothelial cells. Here, we show that LT-induced barrier dysfunction is accompanied by the reduced expression of the endothelial tight junction (TJ) protein claudin-5 but no change in the expres...

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Plos One : Incidence and Mortality of Acute Kidney Injury After My...

By: Antonio Abbate

Description : KDIGO criteria detected substantially more AKI patients than RIFLE among AMI patients. Patients diagnosed as AKI by KDIGO but not RIFLE criteria had a significantly higher early and late mortality. In this study KDIGO criteria were more suitable for AKI diagnosis in AMI patients than RIFLE criteria.

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