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Plos One : Brap2 Regulates Temporal Control of Nf-ҡb Localization ...

By: M. Srinivasula

Description : Nuclear factor-kappaB (NF-kB) is critical for the expression of multiple genes involved in inflammatory responses and cellular survival. NF-kB is normally sequestered in the cytoplasm through interaction with an inhibitor of NF-kB (IkB), but inflammatory stimulation induces proteasomal degradation of IkB, followed by NF-kB nuclear translocation. The degradation of IkB is mediated by a SCF (Skp1-Cullin1-F-box protein)-type ubiquitin ligase complex that is po...

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Plos One : Women’s Roles in Voluntary Medical Male Circumcision in...

By: Paula Braitstein

Description : Women are an important audience for voluntary medical male circumcision (VMMC) communication messages so that they know that VMMC provides only partial protection against HIV. They may also be able to influence their male partners to get circumcised and practice other HIV protective measures after VMMC. This study was conducted in two phases of qualitative data collection. Phase 1 used in-depth interviews to explore women’s understanding of partial protecti...

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Plos One : Integration Host Factor of Mycobacterium Tuberculosis, ...

By: Niyaz Ahmed

Description : The bacterial chromosomal DNA is folded into a compact structure called as ‘nucleoid’ so that the bacterial genome can be accommodated inside the cell. The shape and size of the nucleoid are determined by several factors including DNA supercoiling, macromolecular crowding and nucleoid associated proteins (NAPs). NAPs bind to different sites of the genome in sequence specific or non-sequence specific manner and play an important role in DNA compaction as wel...

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Plos One : Risk Factors of Treatment-limiting Anemia After Substit...

By: F. Okulicz Jason

Description : Our findings argue against the need of weight-based dosing of AZT to reduce anemia among patients using AZT as substitution for D4T. Whether this also applies to ART-naı¨ve individuals remains to be assessed. Future studies with AZT dose reduction should assess efficacy and overall tolerance of AZT.

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Plos One : Bone Marrow Stem Cell Treatment for Ischemic Heart Dise...

By: Yi Zheng

Description : BMSC treatment has significant clinical benefit as stand-alone treatment in patients with IHD and no other treatment option. These results require confirmation in large well-powered trials with long-term follow-up to fully evaluate the clinical efficacy of this treatment.

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Plos One : Estrogen and Progesterone Regulate P27Kip1 Levels Via t...

By: Irina Agoulnik

Description : The levels of proteins that control the cell cycle are regulated by ubiquitin-mediated degradation via the ubiquitinproteasome system (UPS) by substrate-specific E3 ubiquitin ligases. The cyclin-dependent kinase inhibitor, p27kip1 (p27), that blocks the cell cycle in G1, is ubiquitylated by the E3 ligase SCF-Skp2/Cks1 for degradation by the UPS. In turn, Skp2 and Cks1 are ubiquitylated by the E3 ligase complex APC/Cdh1 for destruction thereby maintaining ab...

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Plos One : the Effects of Exercise Under Hypoxia on Cognitive Func...

By: Allan Siegel

Description : Increasing evidence suggests that cognitive function improves during a single bout of moderate exercise. In contrast, exercise under hypoxia may compromise the availability of oxygen. Given that brain function and tissue integrity are dependent on a continuous and sufficient oxygen supply, exercise under hypoxia may impair cognitive function. However, it remains unclear how exercise under hypoxia affects cognitive function. The purpose of this study was to ...

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Plos One : Gene Polymorphisms in African Buffalo Associated with S...

By: Gordon Langsley

Description : Bovine tuberculosis (BTB) is a chronic, highly infectious disease that affects humans, cattle and numerous species of wildlife. In developing countries such as South Africa, the existence of extensive wildlife-human-livestock interfaces poses a significant risk of Mycobacterium bovis transmission between these groups, and has far-reaching ecological, economic and public health impacts. The African buffalo (Syncerus caffer), acts as a maintenance host for My...

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Plos One : Intraoperative Evaluation of Transmitral Pressure Gradi...

By: Tobias Eckle

Description : Edge-to-edge MV repairs are associated with higher intraoperative peak and mean TMPG after separation from CPB compared to conventional repair techniques. Unless gradients are severely elevated, these findings are not necessarily suggestive of iatrogenic MS. Thus, in the immediate postoperative period mildly elevated TMPG can be expected and tolerated after edge-to-edge mitral repairs.

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Plos One : 40S Ribosome Biogenesis Co-factors Are Essential for Ga...

By: Denis Lafontaine

Description : Ribosome biogenesis is well described in Saccharomyces cerevisiae. In contrast only very little information is available on this pathway in plants. This study presents the characterization of five putative protein co-factors of ribosome biogenesis in Arabidopsis thaliana, namely Rrp5, Pwp2, Nob1, Enp1 and Noc4. The characterization of the proteins in respect to localization, enzymatic activity and association with pre-ribosomal complexes is shown. Additiona...

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Plos One : Cytoplasmic Skp2 Expression is Associated with P-akt1 a...

By: Syed A. Aziz

Description : Cytoplasmic Skp2 expression is associated with aggressive prognostic factors, such as larger tumor size, and advanced histological grade of the breast cancers. Results demonstrate that combined cytoplasmic Skp2 and p-Akt1 expression may be prognostic for patients with invasive breast carcinomas, and cytoplasmic Skp2 may serve as a potential therapeutic target.

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Plos One : Ferristatin II Promotes Degradation of Transferrin Rece...

By: Makoto Kanzaki

Description : Previous studies have shown that the small molecule iron transport inhibitor ferristatin (NSC30611) acts by down-regulating transferrin receptor-1 (TfR1) via receptor degradation. In this investigation, we show that another small molecule, ferristatin II (NSC8679), acts in a similar manner to degrade the receptor through a nystatin-sensitive lipid raft pathway. Structural domains of the receptor necessary for interactions with the clathrin pathway do not ap...

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Plos One : Daytime Sleep Enhances Consolidation of the Spatial but...

By: Bruno Van Swinderen

Description : Motor sequence learning is known to rely on more than a single process. As the skill develops with practice, two different representations of the sequence are formed : a goal representation built under spatial allocentric coordinates and a movement representation mediated through egocentric motor coordinates. This study aimed to explore the influence of daytime sleep (nap) on consolidation of these two representations. Through the manipulation of an explici...

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Plos One : Svmtrip ; a Method to Predict Antigenic Epitopes Using ...

By: Aleksey Porollo

Description : Identifying protein surface regions preferentially recognizable by antibodies (antigenic epitopes) is at the heart of new immuno-diagnostic reagent discovery and vaccine design, and computational methods for antigenic epitope prediction provide crucial means to serve this purpose. Many linear B-cell epitope prediction methods were developed, such as BepiPred, ABCPred, AAP, BCPred, BayesB, BEOracle/BROracle, and BEST, towards this goal. However, effective im...

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Plos One : Genome-wide Identification and Comparative Analysis of ...

By: Rakesh N. Veedu

Description : MicroRNAs (miRNAs) are a class of endogenous small non-coding RNAs involved in the post-transcriptional gene regulation and play a critical role in plant growth, development and stresses response. However less is known about miRNAs involvement in grafting behaviors, especially with the watermelon (Citrullus lanatus L.) crop, which is one of the most important agricultural crops worldwide. Grafting method is commonly used in watermelon production in attempts...

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Plos One : Quantification of Cytomegalovirus Glycoprotein Bn Dna i...

By: Cristina Costa

Description : Based on sequence variation in the N-terminus of the UL55 gene, which encodes glycoprotein B (gB), human cytomegalovirus (CMV) can be classified into four gBn genotypes. We assessed the distribution of CMV gBn genotypes and the correlation between CMV gBn DNA (detected by real-time PCR) and CMV-positive pp65 cells (identified by immunohistochemical staining) in a cohort of hematopoietic stem cell transplant patients. The distribution of gB genotypes was as ...

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Plos One : Short Versus Long Term Benefits and the Evolution of Co...

By: Matjaz Perc

Description : this paper I investigate the evolution of cooperation in the prisoner’s dilemma when individuals change their strategies subject to performance evaluation of their neighbours over variable time horizons. In the monochrome setting, in which all agents per default share the same performance evaluation rule, weighing past events strongly dramatically enhances the prevalence of cooperators. For co-evolutionary models, in which evaluation time horizons and strat...

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Plos One : Genome-scale Reconstruction and Analysis of the Metabol...

By: John Parkinson

Description : We describe the reconstruction of a genome-scale metabolic model of the crenarchaeon Sulfolobus solfataricus, a hyperthermoacidophilic microorganism. It grows in terrestrial volcanic hot springs with growth occurring at pH 2–4 (optimum 3.5) and a temperature of 75–80uC (optimum 80uC). The genome of Sulfolobus solfataricus P2 contains 2,992,245 bp on a single circular chromosome and encodes 2,977 proteins and a number of RNAs. The network comprises 718 metab...

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Plos One : Estimating Litter Decomposition Rate in Single-pool Mod...

By: Ben Bond-lamberty

Description : Litter decomposition rate (k) is typically estimated from proportional litter mass loss data using models that assume constant, normally distributed errors. However, such data often show non-normal errors with reduced variance near bounds (0 or 1), potentially leading to biased k estimates. We compared the performance of nonlinear regression using the beta distribution, which is well-suited to bounded data and this type of heteroscedasticity, to standard no...

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Plos One : Polypeptone Induces Dramatic Cell Lysis in Ura4Deletion...

By: F. Janet Partridge

Description : Polypeptone is widely excluded from Schizosaccharomyces pombe growth medium. However, the reasons why polypeptone should be avoided have not been documented. Polypeptone dramatically induced cell lysis in the ura4 deletion mutant when cells approached the stationary growth phase, and this phenotype was suppressed by supplementation of uracil. To determine the specificity of this cell lysis phenotype, we created deletion mutants of other genes involved in de...

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