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Plos One : Direct Diabetes-related Costs in Young Patients with Ea...

By: Maarten Postma

Description : Main cost categories in patients with on average 11 years of diabetes duration were costs for glucose selfmonitoring, insulin pump therapy, hospitalization and insulin. Optimization of glycemic control in particular in pubertal age through intensified care with improved diabetes education and tailored insulin regimen, can contribute to the reduction of direct diabetes-related costs in this patient group.

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Plos One : Cocaine Enhances Hiv-1 Replication in Cd4+ T Cells by D...

By: K.T. Jeang

Description : The main objective of this study was to examine effects of cocaine on HIV-1 replication in primary CD4+ T cells. Cocaine a commonly used drug among HIV-1 positive individuals serves as a cofactor for HIV-1 infection and progression to acquired immunodeficiency syndrome (AIDS). Accumulating evidence suggest that cocaine increases HIV-1 replication in cell cultures, peripheral blood mononuclear cells (PBMCs) and animal models. Intriguingly, there are no studi...

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Plos One : Homoarginine and Mortality in Pre-dialysis Chronic Kidn...

By: Antonio Carlos Seguro

Description : Homoarginine declines with advancing renal disease and is inversely related to progression to dialysis and mortality. The nature of the link between homoarginine and clinical outcomes is amenable to testing in clinical trials.

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Plos One : Specificity of Lipoxygenase Pathways Supports Species D...

By: Tilmann Harder

Description : Oxylipins are low-molecular weight secondary metabolites derived from the incorporation of oxygen into the carbon chains of polyunsaturated fatty acids (PUFAs). Oxylipins are produced in many prokaryotic and eukaryotic lineages where they are involved in a broad spectrum of actions spanning from stress and defense responses, regulation of growth and development, signaling, and innate immunity. We explored the diversity in oxylipin patterns in the marine pla...

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Plos One : Comparison of Montreal Cognitive Assessment and Mini- M...

By: Sonia Brucki

Description : Both the MoCA and the MMSE were successful in differentiating between patients with and without cognitive domain deficits and cognitive impairment at both assessment periods. At 1 year post-ictus, the MoCA produced higher area under the curve scores for cognitive impairment than the MMSE (MoCA, 0.92: 95% CI, 0.83 to 0.97 versus MMSE, 0.77: 95% CI, 0.66 to 0.83, p = 0.009).

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Plos One : Prism ; a Novel Research Tool to Assess the Prevalence ...

By: Xiang Yang Zhang

Description : Data from PRISM, the largest clinic-based study to assess PBA symptom prevalence, showed that PBA symptoms were common among patients with diverse neurological conditions. Higher CNS2LS scores were associated with impaired QOL and greater use of antipsychotic/antidepressant medications. These data underscore a need for greater awareness, recognition, and diagnosis of PBA

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Plos One : Association Between Bacterial Vaginosis and Cervical In...

By: Julius Atashili

Description : Although most studies were cross-sectional and heterogeneity was high, this meta-analysis confirms a connection between BV and CIN.

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Plos One : MacRogenomic Evidence for the Origin of the Black Fly S...

By: Vincent Laudet

Description : To determine the geographic origin of the black fly Simulium suzukii on Okinawa Island, Japan, macrogenomic profiles derived from its polytene chromosomes were compared with those of mainland and other insular populations of S. suzukii and of the isomorphic Simulium tani species complex. The Okinawan population is a chromosomally unique cytoform, designated ‘D,’ which is essentially monomorphic and differs by about 27 fixed rearrangements from the chromosom...

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Plos One : the Impact of Financial Reward Contingencies on Cogniti...

By: Andreas Reif

Description : Taken together, our results support the existence of both cognitive and motivational mechanisms for the disorder, which is in line with current models of ADHD. Furthermore, our data suggest cognitive strategies of ‘‘stopping and thinking’’ as a possible underlying mechanism for task improvement that seems to be mediated by reward, which highlights the importance of the interaction between motivation and cognition in adult ADHD.

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Plos One : a Novel B-cell Epitope Identified Within Mycobacterium ...

By: Yoshihiko Hoshino

Description : There was a B-cell epitope for CE and ESAT-6 protein in the position 40 to 62 of ESAT-6. E5 peptide may be useful in the serodiagnosis of tuberculosis, which need to be further confirmed by more sera samples.

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Plos One : Maximising the Size of Non-redundant Protein Datasets U...

By: Anna Tramontano

Description : Analysis of protein data sets often requires prior removal of redundancy, so that data is not biased by containing similar proteins. This is usually achieved by pairwise comparison of sequences, followed by purging so that no two pairs have similarities above a chosen threshold. From a starting set, such as the PDB or a genome, one should remove as few sequences as possible, to give the largest possible non-redundant set for subsequent analysis. Protein red...

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Plos One : Depletion of the C. Elegans Nac Engages the Unfolded Pr...

By: Alejandro Aballay

Description : The nascent polypeptide-associated complex (NAC) is a highly conserved heterodimer important for metazoan development, but its molecular function is not well understood. Recent evidence suggests the NAC is a component of the cytosolic chaperone network that interacts with ribosomal complexes and their emerging nascent peptides, such that the loss of the NAC in chaperone-depleted cells results in an increase in misfolded protein stress. We tested whether the...

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Plos One : Changes in Cancer Cell Metabolism Revealed by Direct Sa...

By: Julio Francisco Turrens

Description : Biomarker discovery using mass spectrometry (MS) has recently seen a significant increase in applications, mainly driven by the rapidly advancing field of metabolomics. Instrumental and data handling advancements have allowed for untargeted metabolite analyses which simultaneously interrogate multiple biochemical pathways to elucidate disease phenotypes and therapeutic mechanisms. Although most MS-based metabolomic approaches are coupled with liquid chromat...

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Plos One : Cell Cycle Abnormalities Associated with Differential P...

By: Yanchang Wang

Description : Splicing of pre-messenger RNAs into functional messages requires a concerted assembly of proteins and small RNAs that identify the splice junctions and facilitate cleavage of exon-intron boundaries and ligation of exons. One of the key steps in the splicing reaction is the recruitment of a tri-snRNP harboring the U5/U4/U6 snRNPs. The U5 snRNP is also required for both steps of splicing and exon-exon joining. One of the key components of the tri-snRNP is the...

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Plos One : Specific Genomic Regions Are Differentially Affected by...

By: Patrick Tan

Description : Background : Regional genomic copy number alterations (CNA) are observed in the vast majority of cancers. Besides specifically targeting well-known, canonical oncogenes, CNAs may also play more subtle roles in terms of modulating genetic potential and broad gene expression patterns of developing tumors. Any significant differences in the overall CNA patterns between different cancer types may thus point towards specific biological mechanisms acting in those...

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Plos One : the Influence of Interpreters’ Professional Background ...

By: G. Gelovani Juri

Description : With certain experience and training both radiologists and nuclear physicians are qualified to read and to achieve the similar diagnostic accuracy in PET/CT study. Making full use of modality combination and selecting right criteria seems more practical than professional back ground and personal experience in the new hybrid imaging technology, at least when novel tracer or application is concerned.

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Plos One : the Promoter of the Oocyte-specific Gene, Oog1, Functio...

By: Pierre-antoine Defossez

Description : Oog1 is an oocyte-specific gene whose expression is turned on in mouse oocytes at embryonic day (E) 15.5, concomitant with the time when most of the female germ cells stop proliferating and enter meiotic prophase. Here, we characterize the Oog1 promoter, and show that transgenic GFP reporter expression driven by the 2.7 kb and 3.9 kb regions upstream of the Oog1 transcription start site recapitulates the intrinsic Oog1 expression pattern. In addition, the 3...

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Plos One : Screening Compounds with a Novel High-throughput Abcb1-...

By: W. Robert Sobol

Description : ABCB1, also known as P-glycoprotein (P-gp) or multidrug resistance protein 1 (MDR1), is a membrane-associated multidrug transporter of the ATP-binding cassette (ABC) transporter family. It is one of the most widely studied transporters that enable cancer cells to develop drug resistance. Reliable high-throughput assays that can identify compounds that interact with ABCB1 are crucial for developing new therapeutic drugs. A high-throughput assay for measuring...

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Plos One : Global Change and Response of Coastal Dune Plants to th...

By: Anna Traveset

Description : Coastal dune plants are subjected to natural multiple stresses and vulnerable to global change. Some changes associated with global change could interact in their effects on vegetation. As vegetation plays a fundamental role in building and stabilizing dune systems, effective coastal habitat management requires a better understanding of the combined effects of such changes on plant populations. A manipulative experiment was conducted along a Mediterranean d...

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Plos One : Early Clinical and Subclinical Visual Evoked Potential ...

By: Chaoyang Xue

Description : Cryptococcal induced visual loss is a devastating complication in survivors of cryptococcal meningitis (CM). Early detection is paramount in prevention and treatment. Subclinical optic nerve dysfunction in CM has not hitherto been investigated by electrophysiological means. We undertook a prospective study on 90 HIV sero-positive patients with culture confirmed CM. Seventy-four patients underwent visual evoked potential (VEP) testing and 47 patients underwe...

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