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Plos One : In-frame Cdna Library Combined with Protein Complementa...

By: Carol J. Wilusz

Description : The cDNA expression libraries that produce correct proteins are essential in facilitating the identification of protein-protein interactions. The 59-untranslated regions (UTRs) that are present in the majority of mammalian and non-mammalian genes are predicted to alter the expression of correct proteins from cDNA libraries. We developed a novel cDNA expression library from which 59-UTRs were removed using a mixture of polymerase chain reaction primers that ...

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Plos One : Donald’s Ideotype and Growth Redundancy ; a Pot Experim...

By: Ive De Smet

Description : Human selection for high crop yield under water-limited conditions should have led modern cereal cultivars to invest less in root biomass, be it unconsciously. To test this hypothesis we conducted a pot experiment with two spring wheat cultivars, one old and one modern, both widely grown in the semi-arid regions of China. Using the replacement series method introduced by de Wit, we showed that the older landrace (Monkhead) was significantly more competitive...

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Plos One : Influenza Nucleoprotein Delivered with Aluminium Salts ...

By: Andrew Pekosz

Description : Influenza virus poses a difficult challenge for protective immunity. This virus is adept at altering its surface proteins, the proteins that are the targets of neutralizing antibody. Consequently, each year a new vaccine must be developed to combat the current recirculating strains. A universal influenza vaccine that primes specific memory cells that recognise conserved parts of the virus could prove to be effective against both annual influenza variants an...

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Plos One : Prevalence of Major Chronic Conditions Among Older Chin...

By: Jennifer Beam Dowd

Description : This study provides the best available prevalence estimates for major chronic health conditions among older Chinese adults. Findings from this study indicated that major chronic conditions were common, so prevention and early intervention targeting adults aged 50 years and older should be prioritized.

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Plos One : Impact of Microrna Expression in Human Atrial Tissue in...

By: Toru Hosoda

Description : The expression of miRNA-21 in human atrial tissue was found to be related to atrial fibrosis and might affect AF occurrence, indicating its usefulness as a biomarker for cardiac surgery management.

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Plos One : N-3 Poly-unsaturated Fatty Acids Shift Estrogen Signali...

By: Gokul M. Das

Description : Although evidence has shown the regulating effect of n-3 poly-unsaturated fatty acid (n-3 PUFA) on cell signaling transduction, it remains unknown whether n-3 PUFA treatment modulates estrogen signaling. The current study showed that docosahexaenoic acid (DHA, C22:6), eicosapentaenoic acid (EPA, C20:5) shifted the pro-survival and proliferative effect of estrogen to a pro-apoptotic effect in human breast cancer (BCa) MCF-7 and T47D cells. 17 b-estradiol (E2...

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Plos One : Challenges of Culturing Human Norovirus in Three- Dimen...

By: Amit Kapoor

Description : Human noroviruses are the most common cause of acute gastroenteritis worldwide. Recently, cell culture systems have been described using either human embryonic intestinal epithelial cells (Int-407) or human epithelial colorectal adenocarcinoma cells (Caco-2) growing on collagen-I porous micro carrier beads in a rotating bioreactor under conditions of physiological fluid shear. Here, we describe the efforts from two independent laboratories to implement this...

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Plos One : Orfcor ; Identifying and Accommodating Orf Prediction I...

By: Jonathan H. Badger

Description : The high-throughput annotation of open reading frames (ORFs) required by modern genome sequencing projects necessitates computational protocols that sometimes annotate orthologous ORFs inconsistently. Such inconsistencies hinder comparative analyses by non-uniformly extending or truncating 59 and/or 39 sequence ends, causing ORFs that are in fact identical to artificially diverge. Whereas strategies exist to correct such inconsistencies during whole-genome ...

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Plos One : Hiv-1 Drug-resistance Surveillance Among Treatment- Exp...

By: Jason D. Barbour

Description : Despite expanding accessibility to ART in Eastern Ghana, the prevalence of transmitted HIV-1 drug resistance presently appears to be low. As ART provision with limited options is scaled up nationwide in Ghana, careful monitoring of transmitted HIV-1 drug resistance is necessary

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Plos One : Single Nucleotide Polymorphisms in Pathogen Recognition...

By: Heiman Frank Louis Wertheim

Description : Bacterial meningitis (BM) is a serious infection of the central nervous system, frequently occurring in childhood and often resulting in hearing loss, learning disabilities, and encephalopathy. Previous studies showed that genetic variation in innate immune response genes affects susceptibility, severity, and outcome of BM. The aim of this study is to describe whether single nucleotide polymorphisms (SNPs) in pathogen recognition gene products are associate...

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Plos One : Characterization of Nrf1B, a Novel Isoform of the Nucle...

By: Yoshiaki Tsuji

Description : Nuclear factor E2-related factor 1 (Nrf1) is a basic leucine zipper transcription factor that plays an important role in the activation of cytoprotective genes through the antioxidant response elements. The previously characterized long isoform of Nrf1 (Nrf1a) is targeted to the endoplasmic reticulum and accumulates in the nucleus in response to activating signals. Here we characterized a novel Nrf1 protein isoform (Nrf1b) generated through an alternative p...

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Plos One : Getting Your Sea Legs, Volume 8

By: Ramesh Balasubramaniam

Description : Sea travel mandates changes in the control of the body. The process by which we adapt bodily control to life at sea is known as getting one’s sea legs. We conducted the first experimental study of bodily control as maritime novices adapted to motion of a ship at sea. We evaluated postural activity (stance width, stance angle, and the kinematics of body sway) before and during a sea voyage. In addition, we evaluated the role of the visible horizon in the con...

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Plos One : Infectious Complications in Head and Neck Cancer Patien...

By: Gabriele Multhoff

Description : Cetuximab therapy was not statistically associated with infection rate in HNC patients. However, older HNC patients using cetuximab may incur up to 33% infection rate during one year. Particular attention should be given to older HNC patients treated with cetuximab.

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Plos One : Dancing with the Tides ; Fluctuations of Coastal Phytop...

By: Martin Krkosek

Description : Population fluctuations are often driven by an interplay between intrinsic population processes and extrinsic environmental forcing. To investigate this interplay, we analyzed fluctuations in coastal phytoplankton concentration in relation to the tidal cycle. Time series of chlorophyll fluorescence, suspended particulate matter (SPM), salinity and temperature were obtained from an automated measuring platform in the southern North Sea, covering 9 years of d...

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Plos One : Transcriptomics and Comparative Analysis of Three Antar...

By: Cynthia Gibas

Description : For the past 10 to 13 million years, Antarctic notothenioid fish have undergone extraordinary periods of evolution and have adapted to a cold and highly oxygenated Antarctic marine environment. While these species are considered an attractive model with which to study physiology and evolutionary adaptation, they are poorly characterized at the molecular level, and sequence information is lacking. The transcriptomes of the Antarctic fishes Notothenia coriice...

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Plos One : Factors Impacting Early Mortality in Tuberculosis, Volume 7

By: Madhukar Pai

Description : Predictors of early mortality among TB/HIV patients may vary according to the timing of HAART initiation. Among HAART naı¨ve patients, mortality was influenced by baseline clinical severity, HAART use and, possibly, the quality of care preceding TB diagnosis. For patients with prior HAART initiation, longer delays in TB diagnosis predicted a significantly higher mortality.

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Plos One : Being Moved by the Self and Others ; Influence of Empat...

By: Alessio Avenanti

Description : Background : The observation of conspecifics influences our bodily perceptions and actions : Contagious yawning, contagious itching, or empathy for pain, are all examples of mechanisms based on resonance between our own body and others. While there is evidence for the involvement of the mirror neuron system in the processing of motor, auditory and tactile information, it has not yet been associated with the perception of self-motion. Methodology/Principal F...

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Plos One : Influence of Non-alcoholic Fatty Liver Disease on Auton...

By: Manlio Vinciguerra

Description : NAFLD is associated with decreased Ln SDNN and increased 0 V percentage. The former association was independent of conventional cardiovascular risk factors and serum biomarkers (insulin resistance and leptin). Further risk stratification of autonomic dysfunction with falls or cardiovascular diseases by these HRV parameters is required in patients with NAFLD.

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Plos One : Snp Detection in Mrna in Living Cells Using Allele Spec...

By: Cynthia Gibas

Description : Live mRNA detection allows real time monitoring of specific transcripts and genetic alterations. The main challenge of live genetic detection is overcoming the high background generated by unbound probes and reaching high level of specificity with minimal off target effects. The use of Fluorescence Resonance Energy Transfer (FRET) probes allows differentiation between bound and unbound probes thus decreasing background. Probe specificity can be optimized by...

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Plos One : Self-construal Priming Affects Speed of Retrieval from ...

By: Luis M. Martinez

Description : We investigated the effects of collective or individual self-construal priming on recall in a short-term memory (STM) task. We primed participants to either their individual or their collective self-construals or a neutral control condition. Participants then completed a STM retrieval task using either random or patterned digit strings. Findings revealed that priming an individual self-construal resulted in faster retrieval of information from STM for both ...

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