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Plos One : Prognostic Significance of Edn, Volume 8

By: Tao Jiang

Description : The expression of the EDN/RB, HJURP, p60/CAF-1 and PDLI4 proteins is disrupted in high grade gliomas and increases in the levels of these proteins are closely linked to tumour aggressiveness and poor outcome.

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Plos One : Transfection of Infectious Rna and Dna, Volume 8

By: Roger Le Grand

Description : Viral vectors have a wide variety of applications ranging from fundamental studies of viruses to therapeutics. Recombinant viral vectors are usually constructed using methods of reverse genetics to obtain the genetic material of the viral vector. The physicochemical properties of DNA and RNA make them unable to access cells by themselves, and they require assistance to achieve intracellular delivery. Non-viral delivery vectors can be used for this purpose i...

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Plos One : Concurrent Outbreaks of Cholera and Peripheral Neuropat...

By: Sudha Chaturvedi

Description : Cholera likely caused the mostly preventable excess mortality. Peripheral neuropathy was not caused by cholera, but cholera may worsen existing nutritional deficiencies. The peripheral neuropathy was likely caused by complex micronutrient deficiencies linked to non-diversified diets that potentially increased the vulnerability of this population, however a new zinc-associated neuropathy could not be ruled out. Reoccurrence can be prevented by addressing the...

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Plos One : Neuroanatomical Evidence That Kisspeptin Directly Regul...

By: Hubert Vaudry

Description : Neuropeptide kisspeptin has been suggested to be an essential central regulator of reproduction in response to changes in serum gonadal steroid concentrations. However, in spite of wide kisspeptin receptor distribution in the brain, especially in the preoptic area and hypothalamus, the research focus has mostly been confined to the kisspeptin regulation on GnRH neurons. Here, by using medaka whose kisspeptin (kiss1) neurons have been clearly demonstrated to...

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Plos One : Increased Risk of Acute Pancreatitis in Patients with C...

By: Henrik Einwaechter

Description : The risk of acute pancreatitis in patients on long-term hemodialysis is significantly higher in comparison to the general population.

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