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Plos One : Characterization of Pbpga1, an Antigenic Gpi-protein in...

By: Gustavo Henrique Goldman

Description : Paracoccidioides brasiliensis is the etiologic agent of paracoccidioidomycosis (PCM), one of the most prevalent mycosis in Latin America. P. brasiliensis cell wall components interact with host cells and influence the pathogenesis of PCM. Cell wall components, such as glycosylphosphatidylinositol (GPI)-proteins play a critical role in cell adhesion and host tissue invasion. Although the importance of GPI-proteins in the pathogenesis of other medically impor...

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Plos One : Genomic Loss of Tumor Suppressor Mirna-204 Promotes Can...

By: Giuseppe Viglietto

Description : Increasing evidence suggests that chromosomal regions containing microRNAs are functionally important in cancers. Here, we show that genomic loci encoding miR-204 are frequently lost in multiple cancers, including ovarian cancers, pediatric renal tumors, and breast cancers. MiR-204 shows drastically reduced expression in several cancers and acts as a potent tumor suppressor, inhibiting tumor metastasis in vivo when systemically delivered. We demonstrated th...

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Plos One : Clinical Use of Hiv Integrase Inhibitors ; a Systematic...

By: Luis Mene´ndez-arias

Description : In first-line therapy, integrase inhibitors are superior to other regimens. Integrase inhibitor use after virological failure is supported as well by the meta-analysis. Careful use is however warranted when replacing a high genetic barrier drug in treatment-experienced patients switching successful treatment.

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Plos One : Identification of Prostate-specific G-protein Coupled R...

By: Mohammad O. Hoque

Description : We have identified three novel HLA-A2-restricted PSGR-derived peptides recognized by CD8+ T cells, which, in turn, recognize HLA-A2+ and PSGR+ tumor cells. The PSGR-derived peptides identified may be used as diagnostic markers as well as immune targets for development of anticancer vaccines

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Plos One : a Novel Strategy to Increase the Proliferative Potentia...

By: Chunming Liu

Description : Our previous studies demonstrated that Wnt/GSK-3/b-catenin and mTOR signaling are necessary to stimulate proliferative processes in adult human b-cells. Direct inhibition of GSK-3, that engages Wnt signaling downstream of the Wnt receptor, increases b-catenin nuclear translocation and b-cell proliferation but results in lower insulin content. Our current goal was to engage canonical and non-canonical Wnt signaling at the receptor level to significantly incr...

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Plos One : Evaluating Genome-wide Association Study-identified Bre...

By: Paolo Peterlongo

Description : Genome-wide association studies (GWAS), conducted mostly in European or Asian descendants, have identified approximately 67 genetic susceptibility loci for breast cancer. Given the large differences in genetic architecture between the African-ancestry genome and genomes of Asians and Europeans, it is important to investigate these loci in Africanancestry populations. We evaluated index SNPs in all 67 breast cancer susceptibility loci identified to date in o...

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Plos One : Perturbation of Auxin Homeostasis by Overexpression of ...

By: Abidur Rahman

Description : Aux/IAAs interact with auxin response factors (ARFs) to repress their transcriptional activity in the auxin signaling pathway. Previous studies have focused on gain-of-function mutations of domain II and little is known about whether the expression level of wild-type Aux/IAAs can modulate auxin homeostasis. Here we examined the perturbation of auxin homeostasis by ectopic expression of wild-type IAA15. Root gravitropism and stem cell differentiation were al...

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Plos One : in Vitro Blood-brain Barrier Models Using Brain Capilla...

By: Stefan Liebner

Description : The blood–brain barrier (BBB) restricts the entry of circulating drugs and xenobiotics into the brain, and thus its permeability to substances is a critical factor that determines their central effects. The infant brain is vulnerable to neurotoxic substances partly due to the immature BBB. The employment of in vitro BBB models to evaluate permeability of compounds provides higher throughput than that of in vivo animal experiments. However, existing in vitro...

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Plos One : a Pilot Investigation of Visceral Fat Adiposity and Gen...

By: Reury F.P Bacurau

Description : Evidence suggests that visceral fat accumulation plays a central role in the development of metabolic syndrome. Excess visceral fat causes local chronic low-grade inflammation and dysregulation of adipocytokines, which contribute in the pathogenesis of the metabolic syndrome. These changes may affect the gene expression in peripheral blood cells. This study for the first time examined the association between visceral fat adiposity and gene expression profil...

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Plos One : Changes in Bird Functional Diversity Across Multiple La...

By: Zoe G. Davies

Description : Examinations of the impact of land-use change on functional diversity link changes in ecological community structure driven by land modification with the consequences for ecosystem function. Yet, most studies have been small-scale, experimental analyses and primarily focussed on plants. There is a lack of research on fauna communities and at large-scales across multiple land uses. We assessed changes in the functional diversity of bird communities across 24...

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Plos One : Delivery of Therapeutic Agt Shrna by Peg-bu for Hyperte...

By: Abhay Pandit

Description : Gene silencing by RNA interference (RNAi) is a promising approach for gene therapy. However, up to today, it is still a major challenge to find safe and efficient non-viral vectors. Previously, we reported PEI-Bu, a small molecular weight PEI derivative, as an efficient non-viral carrier. However, like many PEI-based polymers, PEI-Bu was too toxic. In order to reduce cytotoxicity while maintain or even enhance transfecion efficiency, we modified PEI-Bu with...

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Plos One : the Antihelmintic Drug Pyrvinium Pamoate Targets Aggres...

By: Ming Tan

Description : WNT signaling plays a key role in the self-renewal of tumor initiation cells (TICs). In this study, we used pyrvinium pamoate (PP), an FDA-approved antihelmintic drug that inhibits WNT signaling, to test whether pharmacologic inhibition of WNT signaling can specifically target TICs of aggressive breast cancer cells. SUM-149, an inflammatory breast cancer cell line, and SUM-159, a metaplastic basal-type breast cancer cell line, were used in these studies. We...

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Plos One : Guillain-barré Syndrome-related Campylobacter Jejuni in...

By: Stefan Bereswill

Description : Background : Campylobacter jejuni is the predominant antecedent infection in Guillain-Barre´ syndrome (GBS). Molecular mimicry and cross-reactive immune responses to C. jejuni lipo-oligosaccharides (LOS) precipitate the development of GBS, although this mechanism has not been established in patients from developing countries. We determined the carbohydrate mimicry between C. jejuni LOS and gangliosides, and the cross-reactive antibody response in patients w...

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Plos One : Proteomic Profiling of Cereal Aphid Saliva Reveals Both...

By: Guy Smagghe

Description : The secreted salivary proteins from two cereal aphid species, Sitobion avenae and Metopolophium dirhodum, were collected from artificial diets and analysed by tandem mass spectrometry. Protein identification was performed by searching MS data against the official protein set from the current pea aphid (Acyrthosiphon pisum) genome assembly and revealed 12 and 7 proteins in the saliva of S. avenae and M. dirhodum, respectively. When combined with a comparable...

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Plos One : Hand Movement Effects on Word Learning and Retrieval in...

By: Joel Snyder

Description : The present study investigated the effect of performing an intentional non-meaningful hand movement on subsequent lexical acquisition and retrieval in healthy adults. Twenty-five right-handed healthy individuals were required to learn the names (2-syllable legal nonwords) for a series of unfamiliar objects. Participants also completed a familiar picture naming task to investigate the effects of the intentional non-meaningful movement on lexical retrieval. R...

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Plos One : Cry2 Genetic Variants Associate with Dysthymia, Volume 8

By: Andreas Reif

Description : People with mood disorders often have disruptions in their circadian rhythms. Recent molecular genetics has linked circadian clock genes to mood disorders. Our objective was to study two core circadian clock genes, CRY1 and CRY2 as well as TTC1 that interacts with CRY2, in relation to depressive and anxiety disorders. Of these three genes, 48 single-nucleotide polymorphisms (SNPs) whose selection was based on the linkage disequilibrium and potential functio...

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Plos One : Computer Simulation of Assembly and Co-operativity of H...

By: Freddie Salsbury

Description : AAA ATPases form a functionally diverse superfamily of proteins. Most members form homo-hexameric ring complexes, are catalytically active only in the fully assembled state, and show co-operativity among the six subunits. The mutual dependence among the subunits is clearly evidenced by the fact that incorporation of mutated, inactive subunits can decrease the activity of the remaining wild type subunits. For the first time, we develop here models to describ...

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Plos One : Structure and Possible Functions of Constant-frequency ...

By: Georges Chapouthier

Description : In the 1970s, Tavolga conducted a series of experiments in which he found behavioral evidence that the vocalizations of the catfish species Ariopsis felis may play a role in a coarse form of echolocation. Based on his findings, he postulated a similar function for the calls of closely related catfish species. Here, we describe the physical characteristics of the predominant calltype of Ariopsis seemanni. In two behavioral experiments, we further explore whe...

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Plos One : Effect of an E-mental Health Approach to Workers’ Healt...

By: Jim Van Os

Description : In our study with a full compliance rate of 6% and substantial drop-out leading to a small and underpowered sample, we could not demonstrate that an EMH-approach to WHS is more effective to improve WF and MH than a control group. The effect found in the complete sample of participants is not easily interpreted. Reported results may be useful for future meta-analytic work.

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Plos One : Interferon-lambda3 Ifn-λ3 and Its Cognate Receptor Subu...

By: F. Rosenberg Helene

Description : Type III IFNs (IFN-ls) constitute a new subfamily with antiviral activities by signaling through a unique receptor complex composed of IFN-ls receptor 1 (IFNlR1) and interleukin-10 receptor 2 (IL10R2). As tree shrews (Tupaia belangeri) have shown susceptiblility to several human viruses, they are a potentially important model for analyzing viral infection. However, little is known about their IFN-ls system. We used the tree shrew genome to retrieve IFN-ls a...

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