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Plos One : Copper Bracelets and Magnetic Wrist Straps for Rheumato...

By: Sam Eldabe

Description : Wearing a magnetic wrist strap or a copper bracelet did not appear to have any meaningful therapeutic effect, beyond that of a placebo, for alleviating symptoms and combating disease activity in rheumatoid arthritis

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Plos One : Association Between Transforming Growth Factor-beta 1 T...

By: Gerard Pasterkamp

Description : This meta-analysis suggested that current epidemiological studies of TGF-b1 T869C polymorphism are too inconsistent to draw a conclusion on the association with IS susceptibility. Given the small sample size and remarkable between-study heterogeneity, further well-designed prospective large-scale studies are warranted.

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Plos One : a Novel Micro-linear Vector for in Vitro and in Vivo Ge...

By: Yi Li

Description : The present study provides a safer, more efficient and stable MiLV gene delivery vector than plasmid. These advantages encourage further development and the preferential use of this novel vector type for clinical gene therapy studies.

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Plos One : Wengen, the Sole Tumour Necrosis Factor Receptor in Dro...

By: Andreas Bergmann

Description : Photoreceptor neurons (R cells) in the Drosophila eye define a map of visual space by connecting to targets in distinct layers of the optic lobe, with R1-6 cells connecting to the lamina (the first optic ganglion) and R7 and R8 cells connecting to the medulla (the second optic ganglion). Here, we show that Wengen (Wgn) directly binds Moesin (Moe) through a cytosolic membrane proximal domain and this interaction is important for mediating two distinct aspect...

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Plos One : Genomic and Proteomic Analyses of the Terminally Redund...

By: Mark J. Van Raaij

Description : We isolated and characterized a new Pseudomonas aeruginosa myovirus named PaP1. The morphology of this phage was visualized by electron microscopy and its genome sequence and ends were determined. Finally, genomic and proteomic analyses were performed. PaP1 has an icosahedral head with an apex diameter of 68–70 nm and a contractile tail with a length of 138–140 nm. The PaP1 genome is a linear dsDNA molecule containing 91,715 base pairs (bp) with a G+C conte...

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Plos One : Increasing Maternal Age is Associated with Taller Statu...

By: Pascale Chavatte-palmer

Description : Increasing maternal age at childbirth is associated with a more favourable phenotype (taller stature and reduced abdominal fat) in their children, as well as improved insulin sensitivity in girls.

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Plos One : Radiation-induced Temporal Lobe Injury for Nasopharynge...

By: William Tse

Description : IMRT is superior to 2DRT for the management of T1-T3 NPC in terms of sparing the temporal lobe. The high incidence of TLI in T4 disease needs to be addressed.

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Plos One : Activation of the Kinin B1 Receptor Attenuates Melanoma...

By: Keiran Smalley

Description : Melanoma is a very aggressive tumor that does not respond well to standard therapeutic approaches, such as radio- and chemotherapies. Furthermore, acquiring the ability to metastasize in melanoma and many other tumor types is directly related to incurable disease. The B1 kinin receptor participates in a variety of cancer-related pathophysiological events, such as inflammation and angiogenesis. Therefore, we investigated whether this G protein-coupled recept...

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Plos One : Interactions Between Zooplankton and Crude Oil ; Toxic ...

By: Stephen J. Johnson

Description : We conducted ship-, shore- and laboratory-based crude oil exposure experiments to investigate (1) the effects of crude oil (Louisiana light sweet oil) on survival and bioaccumulation of polycyclic aromatic hydrocarbons (PAHs) in mesozooplankton communities, (2) the lethal effects of dispersant (Corexit 9500A) and dispersant-treated oil on mesozooplankton, (3) the influence of UVB radiation/sunlight exposure on the toxicity of dispersed crude oil to mesozoop...

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Plos One : Graft Transmission of Rna Silencing to Non-transgenic S...

By: Olle Terenius

Description : RNA silencing is a mechanism of gene regulation by sequence specific RNA degradation and is involved in controlling endogenous gene expression and defense against invasive nucleic acids such as viruses. RNA silencing has been proven to be transmitted between scions and rootstocks through grafting, mostly using transgenic plants. It has been reported that RNA silencing of tobacco endogenous genes, NtTOM1 and NtTOM3, that are required for tobamovirus multipli...

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Plos One : Combinatorial Treatment of Dna and Chromatin- Modifying...

By: Caterina Cinti

Description : Downregulation of microRNAs (miRNAs) at the 14q32 locus stabilizes the expression of cMYC, thus significantly contributing to osteosarcoma (OS) pathobiology. Here, we show that downregulation of 14q32 miRNAs is epigenetically regulated. The predicted promoter regions of miRNA clusters at 14q32 locus showed no recurrent patterns of differential methylation, but Saos2 cells showed elevated histone deacetylase (HDAC) activity. Treatment with 4-phenylbutyrate i...

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Plos One : Interacting Epidemics and Coinfection on Contact Networ...

By: Petter Holme

Description : The spread of certain diseases can be promoted, in some cases substantially, by prior infection with another disease. One example is that of HIV, whose immunosuppressant effects significantly increase the chances of infection with other pathogens. Such coinfection processes, when combined with nontrivial structure in the contact networks over which diseases spread, can lead to complex patterns of epidemiological behavior. Here we consider a mathematical mod...

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Plos One : Rapid Male-specific Regulatory Divergence and Down Regu...

By: Nadia Singh

Description : In most crosses between closely related species of Drosophila, the male hybrids are sterile and show postmeiotic abnormalities. A series of gene expression studies using genomic approaches have found significant down regulation of postmeiotic spermatogenesis genes in sterile male hybrids. These results have led some to suggest a direct relationship between down regulation in gene expression and hybrid sterility. An alternative explanation to a cause-and-eff...

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Plos One : Enhancement of Proteolytic Activity of a Thermostable P...

By: Chandra Verma

Description : Ervatamins (A, B and C) are papain-like cysteine proteases from the plant Ervatamia coronaria. Among Ervatamins, Ervatamin-C is a thermostable protease, but it shows lower catalytic efficiency. In contrast, Ervatamin-A which has a high amino acid sequence identity (,90%) and structural homology (Ca rmsd 0.4 A° ) with Ervatamin-C, has much higher catalytic efficiency (,57 times). From the structural comparison of Ervatamin-A and –C, two residues Thr32 and Ty...

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Plos One : Moderate Heat Challenge Increased Yolk Steroid Hormones...

By: Nei Moreira

Description : Our findings suggest that moderate heat challenge triggers maternal effects and modulate the developmental trajectory of offspring in a way that may be adaptive. This suggests that the impact of heat challenges on captive or wild populations might have a cross-generation effect.

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Plos One : Alcohol Consumption and Viral Load Are Synergistically ...

By: Rui Medeiros

Description : HPV viral load and alcohol was associated with the risk of CIN1 among high-risk HPV-positive women. This is the first demonstration that alcohol is an independent and combined risk factor of CIN1.

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Plos One : Electrospun Polyl-lactide Fiber with Ginsenoside Rg3 fo...

By: Xiaoming He

Description : Hypertrophic scarring (HS) has been considered as a great concern for patients and a challenging problem for clinicians as it can be cosmetically disfiguring and functionally debilitating. In this study, Ginsenoside Rg3/Poly(l-lactide) (G-Rg3/PLLA) electrospun fibrous scaffolds covering on the full-thickness skin excisions location was designed to suppress the hypertrophic scar formation in vivo. SEM and XRD results indicated that the crystal G-Rg3 carried ...

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Plos One : a Potential Novel Spontaneous Preterm Birth Gene, Ar, I...

By: Balraj Mittal

Description : Preterm birth is the major cause of neonatal mortality and morbidity. In many cases, it has severe life-long consequences for the health and neurological development of the newborn child. More than 50% of all preterm births are spontaneous, and currently there is no effective prevention. Several studies suggest that genetic factors play a role in spontaneous preterm birth (SPTB). However, its genetic background is insufficiently characterized. The aim of th...

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Plos One : Prognostic Value of Histological Response to Chemothera...

By: Marta M. Alonso

Description : Histological response is an important and reliable prognostic factor in patients undergoing reconstruction using frozen tumor-bearing autografts.

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Plos One : Selenium Compound Protects Corneal Epithelium Against O...

By: Shree Ram Singh

Description : The ocular surface is strongly affected by oxidative stress, and anti-oxidative systems are maintained in corneal epithelial cells and tear fluid. Dry eye is recognized as an oxidative stress-induced disease. Selenium compound eye drops are expected to be a candidate for the treatment of dry eye. We estimated the efficacy of several selenium compounds in the treatment of dry eye using a dry eye rat model. All of the studied selenium compounds were uptaken i...

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