World Library  


 
  • Cover Image

Plos One : Evolutionary Conservation of the Ribosomal Biogenesis F...

By: Tamir Tuller

Description : Ribosome biogenesis in eukaryotes requires coordinated folding and assembly of a pre-rRNA into sequential pre-rRNAprotein complexes in which chemical modifications and RNA cleavages occur. These processes require many small nucleolar RNAs (snoRNAs) and proteins. Rbm19/Mrd1 is one such protein that is built from multiple RNA-binding domains (RBDs). We find that Rbm19/Mrd1 with five RBDs is present in all branches of the eukaryotic phylogenetic tree, except i...

Read More
  • Cover Image

Plos One : Acetylation of Drosha on the N-terminus Inhibits Its De...

By: Jose M. Sanchez-ruiz

Description : The RNase III enzyme Drosha initiates microRNA (miRNA) biogenesis in the nucleus by cleaving primary miRNA transcripts into shorter precursor molecules that are subsequently exported into the cytoplasm for further processing. While numerous disease states appear to be associated with aberrant expression of Drosha, the molecular mechanisms that regulate its protein levels are largely unknown. Here, we report that ubiquitination and acetylation regulate Drosh...

Read More
  • Cover Image

Plos One : Lung Cancer Cells That Survive Ionizing Radiation Show ...

By: Ferenc Gallyas

Description : Ionizing radiation (IR)-enhanced tumor invasiveness is emerging as a contributor to the limited benefit of radiotherapy: however, its mechanism is still unclear. We previously showed that subcloned lung adenocarcinoma A549 cells (P cells), which survived 10 Gy IR (IR cells), acquired high invasiveness in vitro. Here, we tried to identify the mechanism by which IR cells increase their invasiveness by examining altered gene expression and signaling pathways i...

Read More
  • Cover Image

Plos One : Hogg1Ser326Cys Polymorphism and Risk of Hepatocellular ...

By: Johannes Haybaeck

Description : There is limited evidence to support that the hOGG1 Ser326Cys polymorphism is associated with HCC risk among East Asians. Well-designed and large-sized studies are required to determine this relationship.

Read More
  • Cover Image

Plos One : Trans-kingdom Horizontal Dna Transfer from Bacteria to ...

By: John McCutcheon

Description : With the rapid accumulation of genomic information from various eukaryotes in the last decade, genes proposed to have been derived from recent horizontal gene transfer (HGT) events have been reported even in non-phagotrophic unicellular and multicellular organisms, but the molecular pathways underlying HGT remain to be explained. The development of in vitro HGT detection systems, which permit the molecular and genetic analyses of donor and recipient organis...

Read More
 
1
|
2
|
3
Records: 41 - 45 of 45 - Pages: 



Copyright © World Library Foundation. All rights reserved. eBooks from World Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.