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Plos One : Conservation Actions Based on Red Lists Do Not Capture ...

By: Martin Krkosek

Description : Red Lists of threatened species play a critical role in conservation science and practice. However, policy-making based on Red Lists ignores ecological and evolutionary consequences of losing biodiversity because these lists focus on species alone. To decide if relying on Red Lists alone can help to conserve communities’ functional (FD) and phylogenetic (PD) diversity, it is useful to evaluate whether Red List categories represent species with diverse ecolo...

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Plos One : Oxygen Glucose Deprivation in Rat Hippocampal Slice Cul...

By: Valentin Ceña

Description : Mitochondrial dysfunction characterized by depolarization of mitochondrial membranes and the initiation of mitochondrialmediated apoptosis are pathological responses to hypoxia-ischemia (HI) in the neonatal brain. Carnitine metabolism directly supports mitochondrial metabolism by shuttling long chain fatty acids across the inner mitochondrial membrane for betaoxidation. Our previous studies have shown that HI disrupts carnitine homeostasis in neonatal rats ...

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Plos One : Transmission Patterns of Hiv-subtypes A, Volume 8

By: Mark Wainberg

Description : While sizable transmission networks occur in infected homosexuals, continued HIV transmission among IVDU in Israel is largely sporadic and the rate is relatively modest, as is that of drug-resistance transmission. Deviation of drugnaive A/AE sequences from subtype-B consensus sequence, documented here, may subtly affect drug-resistance pathways. Conspicuous differences in overall drug-resistance that are manifest before regimen stratification can be largely...

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Plos One : Increased Crown-to-implant Ratio May Not Be a Risk Fact...

By: Michael Glogauer

Description : These findings suggest that increased C/I may not be a risk factor for implant failure if the peri-implant mucosa is kept healthy, as was the case in this animal model.

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Plos One : Population Structure of Clinical and Environmental Vibr...

By: Raymond Schuch

Description : Vibrio parahaemolyticus is a common marine bacterium and a leading cause of seafood-borne bacterial gastroenteritis worldwide. Although this bacterium has been the subject of much research, the population structure of cold-water populations remains largely undescribed. We present a broad phylogenetic analysis of clinical and environmental V. parahaemolyticus originating largely from the Pacific Northwest coast of the United States. Repetitive extragenic pal...

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Plos One : Genetic and Morphometric Divergence of an Invasive Bird...

By: Gabriele Sorci

Description : Introduced species are interesting systems for the study of contemporary evolution in new environments because of their spatial and temporal scales. For this study we had three aims : (i) to determine how genetic diversity and genetic differentiation of introduced populations of the house sparrow (Passer domesticus) in Brazil varies with range expansion, (ii) to determine how genetic diversity and differentiation in Brazil compares to ancestral European pop...

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Plos One : Integrated Analysis of Gene Expression Profiles Associa...

By: Sandra Orsulic

Description : We have developed the predictive models and serum biomarkers for platinum/paclitaxel response and established the new approach to discover potential serum biomarkers from gene expression profiles. The potential drugs that target hub genes are also suggested.

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Plos One : Food Addiction ; Its Prevalence and Significant Associa...

By: Jianping Ye

Description : Our results demonstrated that ‘food addiction’ contributes to severity of obesity and body composition measurements from normal weight to obese individuals in the general population with higher rate in women as compared to men.

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Plos One : Low Levels of Gsta1 Expression Are Required for Caco-2 ...

By: Francois Blachier

Description : The colonic epithelium continuously regenerates with transitions through various cellular phases including proliferation, differentiation and cell death via apoptosis. Human colonic adenocarcinoma (Caco-2) cells in culture undergo spontaneous differentiation into mature enterocytes in association with progressive increases in expression of glutathione S-transferase alpha-1 (GSTA1). We hypothesize that GSTA1 plays a functional role in controlling proliferati...

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Plos One : Loss of the Arabidopsis Thaliana P4-atpase Ala3 Reduces...

By: Tai Wang

Description : Members of the P4 subfamily of P-type ATPases are thought to help create asymmetry in lipid bilayers by flipping specific lipids between the leaflets of a membrane. This asymmetry is believed to be central to the formation of vesicles in the secretory and endocytic pathways. In Arabidopsis thaliana, a P4-ATPase associated with the trans-Golgi network (ALA3) was previously reported to be important for vegetative growth and reproductive success. Here we show ...

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Plos One : Magnetic Resonance Spectroscopic Imaging and Volumetric...

By: Gayle E. Woloschak

Description : No relation was found between postcancer fatigue and the studied volumetric and metabolic markers. This may suggest that, although postcancer fatigue and chronic fatigue syndrome show strong resemblances as a clinical syndrome, the underlying physiology is different.

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Plos One : Skeletal Muscle Cells Express Icam-1 After Muscle Overl...

By: Atsushi Asakura

Description : We previously reported that leukocyte specific b2 integrins contribute to hypertrophy after muscle overload in mice. Because intercellular adhesion molecule-1 (ICAM-1) is an important ligand for b2 integrins, we examined ICAM-1 expression by murine skeletal muscle cells after muscle overload and its contribution to the ensuing hypertrophic response. Myofibers in control muscles of wild type mice and cultures of skeletal muscle cells (primary and C2C12) did ...

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Plos One : a Heterozygous Deletion Mutation in the Cardiac Sodium ...

By: Sebastien Fuchs

Description : In a large family, congregation of a heterozygous SCN5A gene mutation (p.1493delK) predisposes for conduction slowing without evidence for Brugada syndrome due to a predominantly trafficking defect that reduces Na+ current and depolarization force. ¨

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Plos One : Porphyromonas Gingivalis Strain Specific Interactions w...

By: Alain-pierre Gadeau

Description : Both epidemiologic and experimental findings suggest that infection with Porphyromonas gingivalis exacerbates progression of atherosclerosis. As P. gingivalis exhibits significant strain variation, it is reasonable that different strains possess different capabilities and/or mechanisms by which they promote atherosclerosis. Using P. gingivalis strains that have been previously evaluated in the ApoE null atherosclerosis model, we assessed the ability of W83,...

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Plos One : Multimodal Mri and 31P-mrs Investigations of the Acta1A...

By: Ruben Artero

Description : Nemaline myopathy (NM), the most common non-dystrophic congenital disease of skeletal muscle, can be caused by mutations in the skeletal muscle α-actin gene (ACTA1) (~25% of all NM cases and up to 50% of severe forms of NM). Muscle function of the recently generated transgenic mouse model carrying the human Asp286Gly mutation in the ACTA1 gene (Tg(ACTA1)Asp286Gly) has been mainly investigated in vitro. Therefore, we aimed at providing a comprehensive pictur...

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Plos One : the Adjuvant Activity of Alphavirus Replicons is Enhanc...

By: Mauricio Martins Rodrigues

Description : Ligands of pattern recognition receptors (PRRs) including Toll-like receptors (TLRs) stimulate innate and adaptive immune responses and are considered as potent adjuvants. Combinations of ligands might act in synergy to induce stronger and broader immune responses compared to stand-alone ligands. Alphaviruses stimulate endosomal TLRs 3, 7 and 8 as well as the cytoplasmic PRR MDA-5, resulting in induction of a strong type I interferon (IFN) response. Bacteri...

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Plos One : Cerebral Oxygen Saturation ; Graded Response to Carbon ...

By: Jorge I F Salluh

Description : Hypocapnia reduces cerebral saturation to an extent equivalent to moderate hypoxia.

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Plos One : Anandamide Reduces Intracellular CA2+ Concentration Thr...

By: Jens Schlossmann

Description : Collectively, these findings suggest that anandamide suppresses calcium overload through inhibition of INCX during perfusion with simulated ischemic solution: the effects may be mediated by CB2 receptor via PTX-sensitive Gi/o proteins. This mechanism is importantly involved in the anti-ischemia injury caused by endocannabinoids

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Plos One : Implementation of Web-based Respondent-driven Sampling ...

By: Patricia Kissinger

Description : Results indicate that webRDS could be implemented at a low cost among Internet-using MSM in Vietnam. WebRDS may be a promising method for sampling of Internet-using MSM and other hidden groups.

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Plos One : Empathy Moderates the Effect of Repetitive Transcranial...

By: Berthold Langguth

Description : Humans incur considerable costs to punish unfairness directed towards themselves or others. Recent studies using repetitive transcranial magnetic stimulation (rTMS) suggest that the right dorsolateral prefrontal cortex (DLPFC) is causally involved in such strategic decisions. Presently, two partly divergent hypotheses are discussed, suggesting either that the right DLPFC is necessary to control selfish motives by implementing culturally transmitted social n...

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