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Plos One : a Substitution in the Ligand Binding Domain of the Porc...

By: Qing Song

Description : Glucocorticoids produced in the adrenal cortex under the control of the hypothalamic-pituitary axis play a vital role in the maintenance of basal and stress-related homeostasis and influence health and well-being. To identify loci affecting regulation of the hypothalamic-pituitary-adrenal (HPA) axis in the pig we performed a genome-wide association study for two parameters of acute and long-term adrenal activity : plasma cortisol level and adrenal weight. W...

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Plos One : Evolutionary Dynamics of Microsatellite Distribution in...

By: Alexander Boris Vinatzer

Description : Despite their ubiquity and functional importance, microsatellites have been largely ignored in comparative genomics, mostly due to the lack of genomic information. In the current study, microsatellite distribution was characterized and compared in the whole genomes and both the coding and non-coding DNA sequences of the sequenced Brassica, Arabidopsis and other angiosperm species to investigate their evolutionary dynamics in plants. The variation in the mic...

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Plos One : Activity of Trifluoperazine Against Replicating, Non- R...

By: Gobardhan Das

Description : Trifluoperazine, a knowm calmodulin antagonist, belongs to a class of phenothiazine compounds that have multiple sites of action in mycobacteria including lipid synthesis, DNA processes, protein synthesis and respiration. The objective of this study is to evaluate the potential of TFP to be used as a lead molecule for development of novel TB drugs by showing its efficacy on multiple drug resistant (MDR) Mycobacterium tuberculosis (M.tb) and non-replicating ...

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Plos One : Blood Pressure Gradients and Cardiovascular Risk Factor...

By: Guoying Wang

Description : Given the high prevalence of hypertension in this part of Nigeria, there is an urgent need to focus on the reduction of preventable CV risk factors we have observed to be associated with hypertension, in order to effectively reduce the burden of NCDs in Africa.

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Plos One : Relation of Pulse Pressure to Long-distance Gait Speed ...

By: Angelo Scuteri

Description : Pulse pressure is associated long-distance gait speed in community-dwelling older adults. Vascular senescence and altered ventricular-vascular coupling may be associated with the deterioration of mobility and physical function in older adults.

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