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Plos One : Housekeeping Gene Selection Advisory ; Glyceraldehyde- ...

By: Georg Stoecklin

Description : Results of overexpression or downregulation of a microRNA (miRNA) on its target mRNA expression are often validated by reverse-transcription and quantitative PCR analysis using an appropriate housekeeping gene as an internal control. The possible direct or indirect effects of a miRNA on the expression of housekeeping genes are often overlooked. Among many housekeeping genes, expressions of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and b-actin have be...

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Plos One : Fully Bayesian Inference for Structural Mri ; Applicati...

By: Fabio Rapallo

Description : Aiming at iron-related T2-hypointensity, which is related to normal aging and neurodegenerative processes, we here present two practicable approaches, based on Bayesian inference, for preprocessing and statistical analysis of a complex set of structural MRI data. In particular, Markov Chain Monte Carlo methods were used to simulate posterior distributions. First, we rendered a segmentation algorithm that uses outlier detection based on model checking techni...

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Plos One : Crucial Role for Cd69 in the Pathogenesis of Dextran Su...

By: Stefan Bereswill

Description : CD69 is a membrane molecule transiently expressed on activated lymphocytes, and its selective expression in inflammatory infiltrates suggests that it plays a role in the pathogenesis of inflammatory diseases. In this study, we used CD69-deficient (CD69 KO) mice to assess the role of CD69 in the pathogenesis of dextran sulphate sodium (DSS)-induced acute and chronic colitis. The severity of colitis was assessed by the survival rate, clinical signs, colon len...

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Plos One : Immunogenicity and Efficacy of Intramuscular Replicatio...

By: Nancy M. Sawtell

Description : Herpes simplex virus type 2 (HSV-2) is a sexually transmitted virus that is highly prevalent worldwide, causing a range of symptoms that result in significant healthcare costs and human suffering. ACAM529 is a replication-defective vaccine candidate prepared by growing the previously described dl5-29 on a cell line appropriate for GMP manufacturing. This vaccine, when administered subcutaneously, was previously shown to protect mice from a lethal vaginal HS...

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Plos One : Interaction Between Obesity and the Nfkb1 - 94Ins, Volume 8

By: Angelo Scuteri

Description : The variant allele of the NFKB1-94ins/delATTG promoter polymorphism did not substantially modify the association between obesity and incident ACS.

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Plos One : Assessing the Congruence of Thermal Niche Estimations D...

By: Sebastien Lavergne

Description : A basic aim of ecology is to understand the determinants of organismal distribution, the niche concept and species distribution models providing key frameworks to approach the problem. As temperature is one of the most important factors affecting species distribution, the estimation of thermal limits is crucially important for inferring range constraints. It is expectable that thermal physiology data derived from laboratory experiments and species’ occurren...

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Plos One : Groundwater Contaminated with Hexavalent Chromium Cr VI...

By: John E. Mendelson

Description : Living in communities with Cr (VI) groundwater is associated with gastrointestinal and dermatological complaints and abnormal hematological function. Limitations of this study include small sample size and the lack of long term follow-up.

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Plos One : Caveolin-1 Expression Level in Cancer Associated Fibrob...

By: Dunfa Peng

Description : Loss of epithelial Cav-1 may promote malignant progression and low CAFs Cav-1 level herald worse outcome of GC patient, suggesting CAFs Cav-1 may be a candidate therapeutic target and a useful prognostic marker of GC.

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Plos One : Virtual Screening as a Strategy for the Identification ...

By: Kang Sun

Description : Screening of virtual chemical structure libraries can facilitate the identification of xenobiotics inhibiting 11b- HSD2 and/or activating MR. Lasalocid and AB110873 belong to new classes of 11b-HSD2 inhibitors. The silane AB110873 represents to the best of our knowledge the first industrial chemical shown to activate MR. Furthermore, the MR pharmacophore can now be used for future screening purposes.

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Plos One : Reduced Prevalence of Oral Human Papillomavirus Hpv 4 Y...

By: Torbjörn Ramqvist

Description : HPV prevalence four years after vaccination with the ASO4-adjuvanted HPV16/18 vaccine was much lower among women in the vaccine arm compared to the control arm, suggesting that the vaccine affords strong protection against oral HPV16/18 infection, with potentially important implications for prevention of increasingly common HPVassociated oropharyngeal cancer.

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Plos One : Visual Experience Determines the Use of External Refere...

By: Andrew Bremner

Description : Vision plays a crucial role in human interaction by facilitating the coordination of one’s own actions with those of others in space and time. While previous findings have demonstrated that vision determines the default use of reference frames, little is known about the role of visual experience in coding action-space during joint action. Here, we tested if and how visual experience influences the use of reference frames in joint action control. Dyads of co...

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Plos One : A1 Noradrenergic Neurons Lesions Reduce Natriuresis and...

By: Nick Ashton

Description : Noradrenergic neurons in the caudal ventrolateral medulla (CVLM: A1 group) contribute to cardiovascular regulation. The present study assessed whether specific lesions in the A1 group altered the cardiovascular responses that were evoked by hypertonic saline (HS) infusion in non-anesthetized rats. Male Wistar rats (280–340 g) received nanoinjections of antidopamine-b-hydroxylase-saporin (A1 lesion, 0.105 ng.nL21) or free saporin (sham, 0.021 ng.nL21) into t...

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Plos One : Integration in Working Memory ; a Magnetic Stimulation ...

By: Tiziana Zalla

Description : Integration is a fundamental working memory operation, requiring the insertion of information from one task into the execution of another concurrent task. Previous neuroimaging studies have suggested the involvement of left anterior prefrontal cortex (L-aPFC) in relation to working memory integration demands, increasing during presentation of information to be integrated (loading), throughout its maintenance during a secondary task, up to the integration st...

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Plos One : a Common Bace1 Polymorphism is a Risk Factor for Sporad...

By: Gianluigi Forloni

Description : The b site APP cleaving enzyme 1 (BACE1) is the rate-limiting b-secretase enzyme in the amyloidogenic processing of APP and Ab formation, and therefore it has a prominent role in Alzheimer’s disease (AD) pathology. Recent evidence suggests that the prion protein (PrP) interacts directly with BACE1 regulating its b-secretase activity. Moreover, PrP has been proposed as the cellular receptor involved in the impairment of synaptic plasticity and toxicity cause...

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Plos One : Seroprevalence of Bactericidal, Specific Igg Antibodies...

By: Li-min Huang

Description : This study provides estimates of natural immunity to NmA, according to a variety of antibody measures, which will be helpful in ascertaining antibody persistence after MenAfriVacTM introduction. Age-specific seroprevalence of reference strain SBA titres most likely reflects exposure to meningococci and consecutive reactive immunity. We could not define any serological correlate of protection.

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Plos One : Heat Transfer in a Micropolar Fluid Over a Stretching S...

By: Chris Lorenz

Description : This article looks at the steady flow of Micropolar fluid over a stretching surface with heat transfer in the presence of Newtonian heating. The relevant partial differential equations have been reduced to ordinary differential equations. The reduced ordinary differential equation system has been numerically solved by Runge-Kutta-Fehlberg fourth-fifth order method. Influence of different involved parameters on dimensionless velocity, microrotation and tempe...

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Plos One : Transcriptional Regulation of Mouse Pxr Gene ; an Inter...

By: Andre Van Wijnen

Description : Pregnane X Receptor (PXR) is an important ligand-activated nuclear receptor functioning as a ‘master regulator’ of expression of phase I, phase II drug metabolizing enzymes, and members of the drug transporters. PXR is primarily expressed in hepatic tissues and to lesser extent in other non-hepatic tissues both in human and in mice. Although its expression profile is well studied but little is known about the regulatory mechanisms that govern PXR gene expre...

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Plos One : Post-hoc Pattern-oriented Testing and Tuning of an Exis...

By: Louis-felix Bersier

Description : Pattern-oriented modeling (POM) is a general strategy for modeling complex systems. In POM, multiple patterns observed at different scales and hierarchical levels are used to optimize model structure, to test and select sub-models of key processes, and for calibration. So far, POM has been used for developing new models and for models of low to moderate complexity. It remains unclear, though, whether the basic idea of POM to utilize multiple patterns, could...

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Plos One : Interferon Regulatory Factor-8 is Important for Histone...

By: Joao P.B. Viola

Description : The notion that epigenetic alterations in neoplasia are reversible has provided the rationale to identify epigenetic modifiers for their ability to induce or enhance tumor cell death. Histone deacetylase inhibitors (HDACi) represent one such class of anti-neoplastic agents. Despite great interest for clinical use, little is known regarding the molecular targets important for response to HDACi-based cancer therapy. We had previously shown that interferon reg...

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Plos One : Applied Mixed Generalized Additive Model to Assess the ...

By: Monica Da Silva Nunes

Description : According to the model estimation, corresponding Risk Ratio to affect BD was close to 1.1 when temperature effect goes up for 1uC in the range from 12uC to 22uC. And the 1-day incubation period could be inferred from the model estimation. Good prediction has been made using the predictive MGAM.

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