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Plos One : the Implications of Temperature-mediated Plasticity in ...

By: Hans G. Dam

Description : Variations in larval instar number are common among arthropods. Here, we assess the implications of temperaturemediated variations in larval instar number for larval development time, larval growth rates, and juvenile dry weight within the palaemonid shrimp, Palaemonetes varians. In contrast with previous literature, which focuses on terrestrial arthropods, particularly model and pest species often of laboratory lines, we use wild shrimp, which differ in th...

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Plos One : Bevacizumab Attenuates Hepatic Fibrosis in Rats by Inhi...

By: Carlos M Rodriguez-ortigosa

Description : Angiogenesis is a fundamental part of the response to tissue injury, which is involved in the development of hepatic fibrosis. Vascular endothelial growth factor plays an important role in angiogenesis. The expression of VEGF is increased during hepatic fibrogenesis and correlates with the micro-vessel density. In this study, we investigated the effects of bevacizumab, an anti-angiogenetic drug, on the formation of hepatic fibrosis. We found that bevacizuma...

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Plos One : Cxcl10 is Critical for the Generation of Protective Cd8...

By: Mauricio Martins Rodrigues

Description : The visceral form of leishmaniasis is the most severe form of the disease and of particular concern due to the emerging problem of HIV/visceral leishmaniasis (VL) co-infection in the tropics. Till date miltefosine, amphotericin B and pentavalent antimony compounds remain the main treatment regimens for leishmaniasis. However, because of severe side effects, there is an urgent need for alternative improved therapies to combat this dreaded disease. In the pre...

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Plos One : Bacterial Meningitis in Brazil Baseline Epidemiologic A...

By: Bernard Beall

Description : Despite the reduction in bacterial meningitis incidence during the last decade, it remains a significant healthcare issue in Brazil. Meningococcal disease is responsible for the majority of the cases with group C the most common capsular type. Our study demonstrates the appropriateness of introduction of meningococcal vaccination in Brazil. Furthermore, this study provides a baseline for future evaluation of the impact of the vaccines introduction in Brazil...

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Plos One : Distractor Detection and Suppression Have a Beneficial ...

By: Trevor Bruce Penney

Description : The present study found when the distractors are detected or identified quickly, they could be effectively suppressed, in order to reduce the interference from the targets and result in a smaller AB deficit. We suggest that the suppression mechanism for distractors have a beneficial effect on AB.

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Plos One : Application of On-line Nanolc-it-tof in the Identificat...

By: Masaru Katoh

Description : Severe burn shock remains an unresolved clinical problem with an urgent need to explore novel therapeutic treatments. Intracellular b-catenin, through interaction with other proteins, has been reported to be able to regulate the size of cutaneous wounds. Higher expression of b-catenin is associated with larger sized wounds. However, the identification of serum b-catenin complex is difficult and has been rarely reported. The exploitation of more binding part...

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Plos One : Circulating Microrna-150 Serum Levels Predict Survival ...

By: Jose Carlos Alves-filho

Description : Reduced miR-150 serum concentrations are associated with an unfavorable outcome in patients with critical illness, independent of the presence of sepsis. Besides a possible pathogenic role of miR-150 in critical illness, our study indicates a potential use of circulating miRNAs as a prognostic rather than diagnostic marker in critically ill patients.

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Plos One : Driving Cessation and Dementia ; Results of the Prospec...

By: Antony Bayer

Description : The risk-estimate of caregivers, but not car accidents or revocation of the driving license determines if dementia patients cease driving. Female gender and increasing impairment in constructional abilities and ADL raise the probability for driving cessation. If any of these factors also relates to undesired traffic situations needs to be determined before recommendations for their inclusion into practice parameters for the assessment of driving abilities i...

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Plos One : Canine Recombinant Adenovirus Vector Induces an Immunog...

By: Roger Le Grand

Description : Gene expression profiling of the blood cell response induced early after vaccination has previously been demonstrated to predict the immunogenicity of vaccines. In this study, we evaluated whether the analysis of the gene expression profile of skin-migrated dendritic cells (DCs) could be informative for the in vitro prediction of immunogenicity of vaccine, using canine adenovirus serotype 2 (CAV2) as vaccine vector. CAV2 has been shown to induce immunity to...

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Plos One : Association of L-ficolin Levels and Fcn2Genotypes with ...

By: M. H. Rooijakkers Suzan

Description : The very first study on Brazilian cohort associates both L-ficolin plasma levels and FCN2 variants to Chagas disease and subsequent disease progression. The prognostic value of L-ficolin levels and the FCN2*A258S polymorphism should be further evaluated in other settings.

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Plos One : Β-diversity of Functional Groups of Woody Plants in a T...

By: Jerome Chave

Description : Two main theories have attempted to explain variation in plant species composition (b-diversity). Niche theory proposes that most of the variation is related to environment (environmental filtering), whereas neutral theory posits that dispersal limitation is the main driver of b-diversity. In this study, we first explored how a- and b-diversity of plant functional groups defined by growth form (trees, shrubs and lianas, which represent different strategies ...

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Plos One : a Critical Interpersonal Distance Switches Between Two ...

By: Ramesh Balasubramaniam

Description : In many competitive sports, players need to quickly and continuously execute movements that co-adapt to various movements executed by their opponents and physical objects. In a martial art such as kendo, players must be able to skillfully change interpersonal distance in order to win. However, very little information about the task and expertise properties of the maneuvers affecting interpersonal distance is available. This study investigated behavioral dyn...

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Plos One : Monocarboxylate Transporter 8 Modulates the Viability a...

By: Cees Oudejans

Description : Monocarboxylate transporter 8 (MCT8) is a well-established thyroid hormone (TH) transporter. In humans, MCT8 mutations result in changes in circulating TH concentrations and X-linked severe global neurodevelopmental delay. MCT8 is expressed in the human placenta throughout gestation, with increased expression in trophoblast cells from growth-restricted pregnancies. We postulate that MCT8 plays an important role in placental development and transplacental TH...

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Plos One : Genome-wide Identification, Phylogeny and Expression Pr...

By: Diane Bassham

Description : Vesicular trafficking plays a crucial role in protein localization and movement, signal transduction, and multiple developmental processes in eukaryotic cells. Vesicle fusion is the final and key step in vesicle-mediated trafficking and mainly relies on SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors), the regulators including SM (Sec1/Munc18) family proteins, Rab GTPases and exocyst subunits. Verticillium dahliae is a widespr...

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Plos One : Tetraspanin Cd9 Promotes the Invasive Phenotype of Huma...

By: Alissa M. Weaver

Description : Tumor cell metastasis, a process which increases the morbidity and mortality of cancer patients, is highly dependent upon matrix metalloproteinase (MMP) production. Small molecule inhibitors of MMPs have proven unsuccessful at reducing tumor cell invasion in vivo. Therefore, finding an alternative approach to regulate MMP is an important endeavor. Tetraspanins, a family of cell surface organizers, play a major role in cell signaling events and have been imp...

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Plos One : Hypoxia-inducible Factors Activate Cd133 Promoter Throu...

By: Kaustubh Datta

Description : CD133 is a cellular surface protein that has been reported to be a cancer stem cell marker, and thus it is considered to be a potential target for cancer treatment. However, the mechanism regulating CD133 expression is not yet understood. In this study, we analyzed the activity of five putative promoters (P1–P5) of CD133 in human embryonic kidney (HEK) 293 cells and colon cancer cell line WiDr, and found that the activity of promoters, particularly of P5, i...

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Plos One : Reverting Antibiotic Tolerance of Pseudomonas Aeruginos...

By: Gunnar F. Kaufmann

Description : BF8 can sensitize P. aeruginosa persister cells to antibiotics.

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Plos One : Functional Coding Variants in Slc6A15, a Possible Risk ...

By: Chunyu Liu

Description : SLC6A15 is a neuron-specific neutral amino acid transporter that belongs to the solute carrier 6 gene family. This gene family is responsible for presynaptic re-uptake of the majority of neurotransmitters. Convergent data from human studies, animal models and pharmacological investigations suggest a possible role of SLC6A15 in major depressive disorder. In this work, we explored potential functional variants in this gene that could influence the activity of...

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Plos One : Insulin Sensitivity from Preschool to School Age in Pat...

By: Franco Folli

Description : In morbidly obese children, insulin sensitivity seems to decline even before pubertal transition, but changes in total adiposity can only partially explain this variation.

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Plos One : Oxygen and an Extracellular Phase Transition Independen...

By: Yong-sun Bahn

Description : Conidiogenesis is the primary process for asexual reproduction in filamentous fungi. As the conidia resulting from the conidiogenesis process are primarily disseminated via air currents and/or water, an outstanding question has been how fungi recognize aerial environments suitable for conidial development. In this study, we documented the somewhat complex development of the conidia-bearing structures, termed conidiophores, from several Aspergillus species i...

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