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Plos One : Attenuation of Kru¨ Ppel-like Factor 4 Facilitates Carc...

By: Rolf Müller

Description : Krüppel-like factor 4 (KLF4) is a transcription factor with diverse functions in various cancer types: however, the function of KLF4 in clear cell renal cell carcinoma (ccRCC) carcinogenesis remains unknown. In this study, we initially examined KLF4 expression by using a cohort of surgically removed ccRCC specimens and cell lines. Results indicated that the transcription and translation of KLF4 were lower in ccRCC tissues than in patient-matched normal tiss...

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Plos One : Serum Metalloproteinases 2 and 9 as Predictors of Gait ...

By: Ulrich Thiem

Description : In conclusion, serum pro-MMP-9 is a predictor of gait status recovery 6 months after hip fracture.

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Plos One : Possible Impacts of the Invasive Plant Rubus Niveus on ...

By: Kurt O. Reinhart

Description : Originally from Asia, Rubus niveus has become one of the most widespread invasive plant species in the Galapagos Islands. It has invaded open vegetation, shrubland and forest alike. It forms dense thickets up to 4 m high, appearing to displace native vegetation, and threaten the integrity of several native communities. This study used correlation analysis between a R. niveus cover gradient and a number of biotic (vascular plant species richness, cover and v...

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Plos One : Future Climate Change will Favour Non-specialist Mammal...

By: Tamara Natasha Romanuk

Description : Arctic and subarctic (i.e., [sub]arctic) ecosystems are predicted to be particularly susceptible to climate change. The area of tundra is expected to decrease and temperate climates will extend further north, affecting species inhabiting northern environments. Consequently, species at high latitudes should be especially susceptible to climate change, likely experiencing significant range contractions. Contrary to these expectations, our modelling of species...

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Plos One : Altered Pancreatic Islet Function and Morphology in Mic...

By: Kathrin Maedler

Description : Neuroligin-2 is a transmembrane, cell-surface protein originally identified as an inhibitory synapse-associated protein in the central nervous system. Neuroligin-2 is also present on the pancreatic beta-cell surface, and there it engages in transcellular interactions that drive functional maturation of the insulin secretory machinery: these are necessary for normal insulin secretion. The effects of neuroligin-2 deficiency on brain and neuronal function and ...

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Plos One : Construction of High-density Genetic Linkage Maps and M...

By: Zhanjiang Liu

Description : High-density genetic linkage maps were constructed for the Japanese flounder (Paralichthys olivaceus). A total of 1624 microsatellite markers were polymorphic in the reference family. Linkage analysis using JoinMap 4.0 resulted in the mapping of 1487 markers to 24 linkage groups, a result which was consistent with the 24 chromosomes seen in chromosome spreads. The female map was composed of 1257 markers, covering a total of 1663.8 cM with an average interva...

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Plos One : Acetyl-l-carnitine Improves Behavior and Dendritic Morp...

By: Huaibin Cai

Description : Rett syndrome (RTT) is a devastating neurodevelopmental disorder affecting 1 in 10,000 girls. Approximately 90% of cases are caused by spontaneous mutations in the X-linked gene encoding methyl-CpG-binding protein 2 (MeCP2). Girls with RTT suffer from severe motor, respiratory, cognitive and social abnomalities attributed to early deficits in synaptic connectivity which manifest in the adult as a myriad of physiological and anatomical abnormalities includin...

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Plos One : Childhood Trauma and Ptsd Symptoms Increase the Risk of...

By: Ulrike Schmidt

Description : A growing body of evidence suggests a link between early childhood trauma, post-traumatic stress disorder (PTSD) and higher risk for dementia in old age. The aim of the present study was to investigate the association between childhood trauma exposure, PTSD and neurocognitive function in a unique cohort of former indentured Swiss child laborers in their late adulthood. To the best of our knowledge this is the first study ever conducted on former indentured ...

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Plos One : a Comparative Analysis of Feeding and Trophic Level Eco...

By: Athanassios C. Tsikliras

Description : Standardised diets and trophic level (TL) estimates were calculated for 75 ray species from the suborders Myliobatoidei (67 spp.) and Torpedinoidei (8 spp.). Decapod crustaceans (31.7163.92%) and teleost fishes (16.4563.43%) made the largest contribution to the standardised diet of the Myliobatoidei. Teleost fishes (37.40616.09%) and polychaete worms (31.96614.22%) were the most prominent prey categories in the standardised diet of the suborder Torpedinoide...

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Plos One : Evaluation of Remote Delivery of Passive Integrated Tra...

By: Andreas Fahlman

Description : Methods to individually mark and identify free-ranging wildlife without trapping and handling would be useful for a variety of research and management purposes. The use of Passive Integrated Transponder technology could be an efficient method for collecting data for mark-recapture analysis and other strategies for assessing characteristics about populations of various wildlife species. Passive Integrated Transponder tags (PIT) have unique numbered frequenci...

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Plos One : Selection for High Oridonin Yield in the Chinese Medici...

By: Ting Wang

Description : Oridonin is a diterpenoid with anti-cancer activity that occurs in the Chinese medicinal plant Isodon rubescens and some related species. While the bioactivity of oridonin has been well studied, the extent of natural variation in the production of this compound is poorly known. This study characterizes natural variation in oridonin production in order to guide selection of populations of Isodon with highest oridonin yield. Different populations of /. rubesc...

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Plos One : the Mechanics of Metastasis ; Insights from a Computati...

By: Zvia Agur

Description : Although it may seem obvious that mechanical forces are required to drive metastatic cell movements, understanding of the mechanical aspects of metastasis has lagged far behind genetic and biochemical knowledge. The goal of this study is to learn about the mechanics of metastasis using a cell-based finite element model that proved useful for advancing knowledge about the forces that drive embryonic cell and tissue movements. Metastasis, the predominant caus...

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Plos One : the Ability of Pvx P25 to Form Rl Structures in Plant C...

By: Boris Alexander Vinatzer

Description : The p25 triple gene block protein of Potato virus X (PVX) is multifunctional, participating in viral movement and acting as a suppressor of RNA silencing. The cell-to-cell movement of PVX is known to depend on the suppression function of p25. GFP-fused p25 accumulates in rod-like (RL) structures with intense fluorescence in cells. By monitoring the location of fluorescence at different times, we have now shown that the RL structure is composed of filaments....

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Plos One : Life Form and Life History Explain Variation in Populat...

By: Brock Fenton

Description : The existence of general characteristics of plant invasiveness is still debated. One reason we may not have found these characteristics is because we do not yet understand how processes underlying population dynamics contribute to community composition in invaded communities. Here I modify Ricker stock-recruitment models to parameterize processes important to community dynamics in an invaded grassland community : immigration, maximum intrinsic growth rate, ...

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Plos One : a Mutation in Mouse Pak1Ip1 Causes Orofacial Clefting W...

By: Li Chen

Description : Orofacial clefts are among the most common birth defects and result in an improper formation of the mouth or the roof of the mouth. Monosomy of the distal aspect of human chromosome 6p has been recognized as causative in congenital malformations affecting the brain and cranial skeleton including orofacial clefts. Among the genes located in this region is PAK1IP1, which encodes a nucleolar factor involved in ribosomal stress response. Here, we report the ide...

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Plos One : Gene Expression Responses to Fus, Ews, and Taf15 Reduct...

By: Huaibin Cai

Description : The FET family of proteins is composed of FUS/TLS, EWS/EWSR1, and TAF15 and possesses RNA- and DNA-binding capacities. The FET-proteins are involved in transcriptional regulation and RNA processing, and FET-gene deregulation is associated with development of cancer and protein granule formations in amyotrophic lateral sclerosis, frontotemporal lobar degeneration, and trinucleotide repeat expansion diseases. We here describe a comparative characterization of...

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Plos One : Synchronous Recruitment of Epigenetic Modifiers to Endo...

By: Charalampos Babis Spilianakis

Description : Our results suggest that I/R and LPS differentially trigger phosphorylation (Pol II and histone) and acetylation (histone) epigenetic pathways that interact at the Tnf-a gene to generate endotoxin hyperresponse in AKI.

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Plos One : Tusc1, a Putative Tumor Suppressor Gene, Reduces Tumor ...

By: William B. Coleman

Description : We previously reported the identification of TUSC1 (Tumor Suppressor Candidate 1), as a novel intronless gene isolated from a region of homozygous deletion at D9S126 on chromosome 9p in human lung cancer. In this study, we examine the differential expression of TUSC1 in human lung cancer cell lines by western blot and in a primary human lung cancer tissue microarray by immunohistochemical analysis. We also tested the functional activities and mechanisms of ...

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Plos One : Predicting the Functional Effect of Amino Acid Substitu...

By: Alexandre G. De Brevern

Description : As next-generation sequencing projects generate massive genome-wide sequence variation data, bioinformatics tools are being developed to provide computational predictions on the functional effects of sequence variations and narrow down the search of casual variants for disease phenotypes. Different classes of sequence variations at the nucleotide level are involved in human diseases, including substitutions, insertions, deletions, frameshifts, and non-sense...

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Plos One : a Phylogenomic Perspective on the Radiation of Ray- Fin...

By: Corrie S. Moreau

Description : Ray-finned fishes constitute the dominant radiation of vertebrates with over 32,000 species. Although molecular phylogenetics has begun to disentangle major evolutionary relationships within this vast section of the Tree of Life, there is no widely available approach for efficiently collecting phylogenomic data within fishes, leaving much of the enormous potential of massively parallel sequencing technologies for resolving major radiations in ray-finned fis...

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