World Library  


 
  • Cover Image

Plos One : Differential Response of Hippocampal Subregions to Stre...

By: Ulrike Schmidt

Description : The hippocampus has two functionally distinct subregions–the dorsal portion, primarily associated with spatial navigation, and the ventral portion, primarily associated with anxiety. In a prior study of chronic unpredictable stress (CUS) in rodents, we found that it selectively enhanced cellular plasticity in the dorsal hippocampal subregion while negatively impacting it in the ventral. In the present study, we determined whether this adaptive plasticity in...

Read More
  • Cover Image

Plos One : Regulator of G-protein Signalling-14 Rgs14 Regulates th...

By: Jon C.D. Houtman

Description : Integrin-mediated phagocytosis, an important physiological activity undertaken by professional phagocytes, requires bidirectional signalling to/from αMβ2 integrin and involves Rap1 and Rho GTPases. The action of Rap1 and the cytoskeletal protein talin in activating αMβ2 integrins, in a RIAM-independent manner, has been previously shown to be critical during phagocytosis in mammalian phagocytes. However, the events downstream of Rap1 are not clearly understo...

Read More
  • Cover Image

Plos One : Effect of Supervised Students’ Involvement on Diagnosti...

By: James Logerfo

Description : Involvement of closely supervised medical students in the evaluation process of hospitalized medical patients leads to an improved diagnostic accuracy compared to evaluation by an emergency department physician alone.

Read More
  • Cover Image

Plos One : the Ahl- and Bdsf-dependent Quorum Sensing Systems Cont...

By: Willem Van Schaik

Description : Quorum sensing in Burkholderia cenocepacia H111 involves two signalling systems that depend on different signal molecules, namely N-acyl homoserine lactones (AHLs) and the diffusible signal factor cis-2-dodecenoic acid (BDSF). Previous studies have shown that AHLs and BDSF control similar phenotypic traits, including biofilm formation, proteolytic activity and pathogenicity. In this study we mapped the BDSF stimulon by RNA-Seq and shotgun proteomics analysi...

Read More
  • Cover Image

Plos One : Modeling the Role of Negative Cooperativity in Metaboli...

By: Peter Csermely

Description : A significant proportion of enzymes display cooperativity in binding ligand molecules, and such effects have an important impact on metabolic regulation. This is easiest to understand in the case of positive cooperativity. Sharp responses to changes in metabolite concentrations can allow organisms to better respond to environmental changes and maintain metabolic homeostasis. However, despite the fact that negative cooperativity is almost as common as positi...

Read More
  • Cover Image

Plos One : Limited T Cell Receptor Repertoire Diversity in Tubercu...

By: Francesco Dieli

Description : Results from this study promote a better knowledge about the public characteristics of T cells among TB patients and provides new insight into the TCR repertoire associated with clinic presentation in TB patients.

Read More
  • Cover Image

Plos One : Flight Performance and Feather Quality ; Paying the Pri...

By: Nicola Saino

Description : A temporal separation of energetically costly life history events like reproduction and maintenance of the integumentary system is thought to be promoted by selection to avoid trade-offs and maximize fitness. It has therefore remained somewhat of a paradox that certain vertebrate species can undergo both events simultaneously. Identifying potential costs of overlapping two demanding life history stages will further our understanding of the selection pressur...

Read More
  • Cover Image

Plos One : a Novel Homozygous P.R1105X Mutation of the Ap4E1 Gene ...

By: Gisela Nogales-gadea

Description : We report identical twins with intellectual disability, progressive spastic paraplegia and short stature, born to a consanguineous family. Intriguingly, both children presented with lymphadenitis caused by the live Bacillus Calmette- Gue´rin (BCG) vaccine. Two syndromes – hereditary spastic paraplegia (HSP) and mycobacterial disease – thus occurred simultaneously. Whole-exome sequencing (WES) revealed a homozygous nonsense mutation (p.R1105X) of the AP4E1 g...

Read More
  • Cover Image

Plos One : Xzh-5 Inhibits Stat3 Phosphorylation and Enhances the C...

By: Jun Li

Description : Constitutive activation of Signal Transducers and Activators of Transcription 3 (STAT3) signaling is frequently detected in breast and pancreatic cancer. Inhibiting constitutive STAT3 signaling represents a promising molecular target for therapeutic approach. Using structure-based design, we developed a non-peptide cell-permeable, small molecule, termed as XZH-5, which targeted STAT3 phosphorylation. XZH-5 was found to inhibit STAT3 phosphorylation (Tyr705)...

Read More
  • Cover Image

Plos One : Ssu Ribosomal Dna-based Monitoring of Nematode Assembla...

By: Ahmed Moustafa

Description : Soils are among the most complex, diverse and competitive habitats on Earth and soil biota are responsible for ecosystem services such as nutrient cycling, carbon sequestration and remediation of freshwater. The extreme biodiversity prohibits the making of a full inventory of soil life. Hence, an appropriate indicator group should be selected to determine the biological condition of soil systems. Due to their ubiquity and the diverse responses to abiotic an...

Read More
  • Cover Image

Plos One : Plant Trait-species Abundance Relationships Vary with E...

By: Justin Wright

Description : Understanding how plant trait-species abundance relationships change with a range of single and multivariate environmental properties is crucial for explaining species abundance and rarity. In this study, the abundance of 94 woody plant species was examined and related to 15 plant leaf and wood traits at both local and landscape scales involving 31 plots in subtropical forests in eastern China. Further, plant trait-species abundance relationships were relat...

Read More
  • Cover Image

Plos One : Advanced Glycation End Products in Infant Formulas Do N...

By: Michael Müller

Description : In healthy term infants, high dietary load with CML does not play a pathophysiological role in the induction of infant formula-associated insulin resistance. Whether a high load of AGEs in early childhood affects postnatal programming remains to be elucidated.

Read More
  • Cover Image

Plos One : Replication and Transcription Activities of Ribonucleop...

By: Shamala Devi Sekaran

Description : Avian influenza viruses pose a serious pandemic threat to humans. Better knowledge on cross-species adaptation is important. This study examined the replication and transcription efficiency of ribonucleoprotein complexes reconstituted by plasmid co-transfection between H5N1, H1N1pdm09 and H3N2 influenza A viruses, and to identify mutations in the RNA polymerase subunit that affect human adaptation. Viral RNA polymerase subunits PB1, PB2, PA and NP derived f...

Read More
  • Cover Image

Plos One : Individual Differences in Foraging Strategies of Parasi...

By: Cedric Sueur

Description : Originally, evolutionary game theory typically predicted that optimal behaviour in a given situation is uniform or bimodal. However, the growing evidence that animals behave more variably while individuals may differ consistently in their behaviour, has led to the development of models that predict a distribution of strategies. Here we support the importance of such models in a study on a coral reef fish host–parasite system. Parasitic blennies (Plagiotremu...

Read More
  • Cover Image

Plos One : the Relationship Between Respiration-related Membrane P...

By: Miguel Maravall

Description : Background : A slow respiration-related rhythm strongly shapes the activity of the olfactory bulb. This rhythm appears as a slow oscillation that is detectable in the membrane potential, the respiration-related spike discharge of the mitral/tufted cells and the bulbar local field potential. Here, we investigated the rules that govern the manifestation of membrane potential slow oscillations (MPSOs) and respiration-related discharge activities under various ...

Read More
  • Cover Image

Plos One : Functional Investigation of Nci-h460-inducible Myofibro...

By: Francesco Pappalardo

Description : Fibroblasts, the major cell type in tumor stroma, are essential for tumor growth and survival, and represent an important therapeutic target for cancers. Here we presented a microfluidic co-culture device in which the three-dimensional (3D) matrix was employed to reconstruct an in vivo-like fibroblast-tumor cell microenvironment for investigation of the role of myofibroblasts induced by lung cancer cells in the chemoresistance to VP-16. Composed of a double...

Read More
  • Cover Image

Plos One : Ionic Mechanism Underlying Optimal Stimuli for Neuronal...

By: Miguel Maravall

Description : The ionic mechanism underlying optimal stimulus shapes that induce a neuron to fire an action potential, or spike, is relevant to understanding optimal information transmission and therapeutic stimulation in the nervous system. Here we analyze for the first time the ionic basis for stimulus optimality in the Hodgkin and Huxley model and for eliciting a spike in squid giant axons, the preparation for which the model was devised. The experimentally determined...

Read More
  • Cover Image

Plos One : Eubacterial Spovg Homologs Constitute a New Family of S...

By: Ronald Mark Wooten

Description : A site-specific DNA-binding protein was purified from Borrelia burgdorferi cytoplasmic extracts, and determined to be a member of the highly conserved SpoVG family. This is the first time a function has been attributed to any of these ubiquitous bacterial proteins. Further investigations into SpoVG orthologues indicated that the Staphylococcus aureus protein also binds DNA, but interacts preferentially with a distinct nucleic acid sequence. Site-directed mu...

Read More
  • Cover Image

Plos One : the Study of Cognitive Characteristics in Asperger’s Di...

By: Attila Szolnoki

Description : Individuals with Asperger’s Disorder (ASP) have difficulties in social reciprocity and in providing appropriate cooperative behavior. The Prisoner’s Dilemma (PD) is a well-known model in game theory that illustrates the paradoxical disposition of interaction between two individuals with opposing interests, and may be a useful tool in the diagnosis of ASP in early childhood. In this study, we investigated the cognitive characteristics of ASP by using a modif...

Read More
  • Cover Image

Plos One : Protein Kinase G1 Α Overexpression Increases Stem Cell ...

By: Anversa Piero

Description : Overexpression of PKG1a transgene could be a powerful approach to improve MSCs survival and their angiomyogenic potential in the infarcted heart.

Read More
 
1
|
2
|
3
Records: 1 - 20 of 45 - Pages: 



Copyright © World Library Foundation. All rights reserved. eBooks from World Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.