World Library  


 
  • Cover Image

Plos One : Serious Treatment Related Adverse Drug Reactions Amongs...

By: Madhukar Pai

Description : We found that being HIV-infected but antiretroviral naı¨ve did not increase occurrence of SADRs in patients on second-line anti-tuberculosis drugs. Early screening and proactive management of ADRs in this patient population is essential, especially given the rollout of decentralized care and the potential for overlapping toxicity of concomitant MDRTB and HIV treatment.

Read More
  • Cover Image

Plos One : Fibrillin-1 Mutations Causing Weill-marchesani Syndrome...

By: Xin Zhang

Description : The extracellular glycoprotein fibrillin-1 forms microfibrils that act as the template for elastic fibers. Most mutations in fibrillin-1 cause Marfan syndrome with severe cardiovascular and ocular symptoms, and tall stature. This is in contrast to mutations within a heparin-binding TB domain (TB5), which is downstream of the arg-gly-asp cell adhesion domain, which can cause Weill-Marchesani syndrome (WMS) or Acromicric (AD) and Geleophysic Dysplasias (GD). ...

Read More
  • Cover Image

Plos One : Omigapil Treatment Decreases Fibrosis and Improves Resp...

By: Thomas H. Gillingwater

Description : Omigapil therapy (0.1 mg/kg) improved respiratory rate and decreased skeletal and respiratory muscle fibrosis in dy2J mice. These results support a putative role for the use of omigapil in laminin deficient congenital muscular dystrophy patients.

Read More
  • Cover Image

Plos One : Dna Methylation in the Neuropeptide S Receptor 1 Npsr1 ...

By: Susanne Krauss-etschmann

Description : Asthma and allergy are complex disorders influenced by both inheritance and environment, a relationship that might be further clarified by epigenetics. Neuropeptide S Receptor 1 (NPSR1) has been associated with asthma and allergy and a study suggested modulation of the genetic risk by environmental factors. We aimed to study DNA methylation in the promoter region of NPSR1 in relation to asthma and environmental exposures. Electrophoretic Mobility Shift Assa...

Read More
  • Cover Image

Plos One : the P2Y12 Antagonists, 2Mesamp and Cangrelor, Inhibit P...

By: Ching-ping Tseng

Description : These data together demonstrate that 2MeSAMP and Cangrelor inhibit platelet function through the P2Y12- dependent mechanism both in vitro and in vivo.

Read More
  • Cover Image

Plos One : Integrated Analysis of Global Mrna and Protein Expressi...

By: Qi Zeng

Description : This systems-level approach sheds new light on the molecular networks underlying PRL-1 action and presents several novel directions for future, hypothesis-based studies.

Read More
  • Cover Image

Plos One : Deletion of C7L and K1L Genes Leads to Significantly De...

By: Yuntao Wu

Description : The vaccinia virus TianTan (VTT) has been modified as an HIV vaccine vector in China and has shown excellent performance in immunogenicity and safety. However, its adverse effects in immunosuppressed individuals warrant the search for a safer vector in the following clinic trails. In this study, we deleted the C7L and K1L genes of VTT and constructed six recombinant vaccinia strains VTT△C7L, VTT△K1L, VTT△C7LK1L, VTKgpe△C7L, VTKgpe△K1L and VTT△C7LK1L-gag. Th...

Read More
  • Cover Image

Plos One : Contribution of Individual Ebp Pilus Subunits of Entero...

By: Lynn E. Hancock

Description : The endocarditis and biofilm-associated pilus (Ebp) operon is a component of the core genome of Enterococcus faecalis that has been shown to be important for biofilm formation, adherence to host fibrinogen, collagen and platelets, and in experimental endocarditis and urinary tract infection models. Here, we created single and double deletion mutants of the pilus subunits and sortases: next, by combining western blotting, immunoelectron microscopy, and using...

Read More
  • Cover Image

Plos One : How Spatial Variation in Areal Extent and Configuration...

By: Han Y.H. Chen

Description : The Arctic tundra is currently experiencing an unprecedented combination of climate change, change in grazing pressure by large herbivores and growing human activity. Thickets of tall shrubs represent a conspicuous vegetation state in northern and temperate ecosystems, where it serves important ecological functions, including habitat for wildlife. Thickets are however labile, as tall shrubs respond rapidly to both abiotic and biotic environmental drivers. O...

Read More
  • Cover Image

Plos One : Genome-wide Relatedness of Treponema Pedis, from Gingiv...

By: Odir a Dellagostin

Description : Treponema pedis and T. denticola are two genetically related species with different origins of isolation. Treponema denticola is part of the human oral microbiota and is associated with periodontitis while T. pedis has been isolated from skin lesions in animals, e.g., digital dermatitis in cattle and necrotic ulcers in pigs. Although multiple Treponema phylotypes may exist in ulcerative lesions in pigs, T. pedis appears to be a predominant spirochete in the...

Read More
  • Cover Image

Plos One : Diminazene Aceturate Berenil Modulates the Host Cellula...

By: Martin E. Rottenberg

Description : Collectively, these results provide evidence that in addition to its direct trypanolytic effect, Berenil also modulates the host immune response to the parasite in a manner that dampen excessive immune activation and production of pathology-promoting pro-inflammatory cytokines, suggesting that this drug may also be beneficial for treatment of disease conditions caused by excessive production of inflammatory cytokines.

Read More
  • Cover Image

Plos One : Virtual Screening as a Strategy for the Identification ...

By: Stefan Bereswill

Description : Taken together, these results implicate type II activated macrophages as an important innate immune source of IL-4 that may play an important role in shaping adaptive immune responses.

Read More
  • Cover Image

Plos One : Biochemical and Mutational Analysis of a Novel Nicotina...

By: Vasu D. Appanna

Description : Nicotinamidases catalyze the hydrolysis of nicotinamide to nicotinic acid and ammonia, an important reaction in the NAD+ salvage pathway. This paper reports a new nicotinamidase from the deep-sea extremely halotolerant and alkaliphilic Oceanobacillus iheyensis HTE831 (OiNIC). The enzyme was active towards nicotinamide and several analogues, including the prodrug pyrazinamide. The enzyme was more nicotinamidase (kcat/Km = 43.5 mM21s21) than pyrazinamidase (k...

Read More
  • Cover Image

Plos One : Gene Network Analysis in a Pediatric Cohort Identifies ...

By: Wenge Guo

Description : Lung function is a heritable trait and serves as an important clinical predictor of morbidity and mortality for pulmonary conditions in adults, however, despite its importance, no studies have focused on uncovering pediatric-specific loci influencing lung function. To identify novel genetic determinants of pediatric lung function, we conducted a genome-wide association study (GWAS) of four pulmonary function traits, including FVC, FEV1, FEV1/FVC and FEF25–7...

Read More
  • Cover Image

Plos One : Nitric Oxide Deficiency Accelerates Chlorophyll Breakdo...

By: Minami Matsui

Description : Nitric oxide (NO) has been known to preserve the level of chlorophyll (Chl) during leaf senescence. However, the mechanism by which NO regulates Chl breakdown remains unknown. Here we report that NO negatively regulates the activities of Chl catabolic enzymes during dark-induced leaf senescence. The transcriptional levels of the major enzyme genes involving Chl breakdown pathway except for RED CHL CATABOLITE REDUCTASE (RCCR) were dramatically up-regulated d...

Read More
  • Cover Image

Plos One : Perinatal Na+ Overload Programs Raised Renal Proximal N...

By: Nick Ashton

Description : Background : High Na+ intake is a reality in nowadays and is frequently accompanied by renal and cardiovascular alterations. In this study, renal mechanisms underlying perinatal Na+ overload-programmed alterations in Na+ transporters and the renin/angiotensin system (RAS) were investigated, together with effects of short-term treatment with enalapril in terms of reprogramming molecular alterations in kidney. Methodology/Principal Findings : Male adult Wista...

Read More
  • Cover Image

Plos One : Mertk Interactions with Sh2-domain Proteins in the Reti...

By: Mike O. Karl

Description : The receptor tyrosine kinase MERTK plays an essential role in the phagocytic uptake of shed photoreceptor membranes by the retinal pigment epithelium (RPE). A fundamental aspect of signal transduction by receptor tyrosine kinases involves autophosphorylation of tyrosine residues that recruit Src-homology 2 (SH2)-domain proteins to the receptor intracellular domain. The goal of the current study was to evaluate the interactions of human MERTK with SH2-domain...

Read More
  • Cover Image

Plos One : Prevalence of Diabetic Retinopathy in Mainland China ; ...

By: Demetrios Vavvas

Description : The prevalence of DR in mainland China appeared a little high, and varied according to area. NPDR was more common. This study highlights the necessity for DR screening in the rural areas of China.

Read More
  • Cover Image

Plos One : Periodontal Disease and Risk of Chronic Obstructive Pul...

By: Lynette Kay Rogers

Description : Based on current evidence, PD is a significant and independent risk factor of COPD. However, whether a causal relationships exists remains unclear. Morever, we suggest performing randomized controlled trails to explore whether periodontal interventions are beneficial in regulating COPD pathogenesis and progression.

Read More
  • Cover Image

Plos One : Previous Exposure to an Rna Virus Does Not Protect Agai...

By: Nicole M. Gerardo

Description : Our results confirm the finding that ‘acquired’ immune responses are not ubiquitous across all invertebratepathogen interactions. We discuss why we may have observed no effect in this study, with focus on the mechanistic basis of the RNAi pathway.

Read More
 
1
|
2
|
3
Records: 1 - 20 of 45 - Pages: 



Copyright © World Library Foundation. All rights reserved. eBooks from World Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.