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Plos One : Maternal Serum Heme-oxygenase-1 Ho-1 Concentrations in ...

By: Ana Claudia Zenclussen

Description : Serum HO-1 concentrations were inversely associated with subsequent GDM risk. These findings underscore the role of oxidative stress in the pathogenesis of GDM. Additional studies are warranted to confirm the clinical utility of serum HO-1 in diagnosis of GDM, particularly in the early pregnancy.

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Plos One : Chronic Alcohol Ingestion Increases Mortality and Organ...

By: Charles C. Caldwell

Description : Background : Patients admitted to the intensive care unit with alcohol use disorders have increased morbidity and mortality. The purpose of this study was to determine how chronic alcohol ingestion alters the host response to sepsis in mice. Methods : Mice were randomized to receive either alcohol or water for 12 weeks and then subjected to cecal ligation and puncture. Mice were sacrificed 24 hours post-operatively or followed seven days for survival. Resul...

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Plos One : Access to Essential Medicines in Pakistan ; Policy and ...

By: John G. Meara

Description : Experience from Pakistan shows that policy concerns related to essential medicine access need integrated responses across various components of the health systems, are poorly addressed by existing evidence, and require an expanded health systems research agenda.

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Plos One : Cathepsin G-dependent Modulation of Platelet Thrombus F...

By: Alexander Zarbock

Description : Neutrophils are consistently associated with arterial thrombotic morbidity in human clinical studies but the causal basis for this association is unclear. We tested the hypothesis that neutrophils modulate platelet activation and thrombus formation in vivo in a cathepsin G-dependent manner. Neutrophils enhanced aggregation of human platelets in vitro in dosedependent fashion and this effect was diminished by pharmacologic inhibition of cathepsin G activity ...

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Plos One : Mesenchymal Stem Cells in Inflammation Microenvironment...

By: Xin-yuan Guan

Description : In response to inflammation, mesenchymal stem cells (MSCs) are known to migrate to tissue injury sites to participate in immune modulation, tissue remodeling and wound healing. Tumors apply persistent mechanical and pathological stress to tissues and causes continual infiltration of MSCs. Here, we demonstrate that MSCs promote human hepatocellular carcinoma (HCC) metastasis under the influence of inflammation. The metastasis promoting effect could be imitat...

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Plos One : Getting a Grip on Memory ; Unilateral Hand Clenching Al...

By: Lesley Joy Rogers

Description : Unilateral hand clenching increases neuronal activity in the frontal lobe of the contralateral hemisphere. Such hand clenching is also associated with increased experiencing of a given hemisphere’s ‘‘mode of processing.’’ Together, these findings suggest that unilateral hand clenching can be used to test hypotheses concerning the specializations of the cerebral hemispheres during memory encoding and retrieval. We investigated this possibility by testing eff...

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Plos One : a Simulation Tool for Dynamic Contrast Enhanced Mri, Vo...

By: Angelique Louie

Description : The quantification of bolus-tracking MRI techniques remains challenging. The acquisition usually relies on one contrast and the analysis on a simplified model of the various phenomena that arise within a voxel, leading to inaccurate perfusion estimates. To evaluate how simplifications in the interstitial model impact perfusion estimates, we propose a numerical tool to simulate the MR signal provided by a dynamic contrast enhanced (DCE) MRI experiment. Our m...

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Plos One : Selection of Reliable Reference Genes for Gene Expressi...

By: Christian Schönbach

Description : Quantitative real-time PCR (RT-qPCR) has become an accurate and widely used technique to analyze expression levels of selected genes. It is very necessary to select appropriate reference genes for gene expression normalization. In the present study, we assessed the expression stability of 11 reference genes including eight traditional housekeeping genes and three novel genes in different tissues/organs and developing seeds from four cultivars of tung tree. ...

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Plos One : the Impact of Successful Cataract Surgery on Quality of...

By: John E Mendelson

Description : These findings indicate the broad positive impact of sight restoring cataract surgery on the recipients’ as well as their families’ lives. Providing free high quality cataract surgery to marginalized rural communities will not only alleviate avoidable blindness but also - to some extent - poverty in the long run.

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Plos One : Clonal Expansion and Emergence of Environmental Multipl...

By: Oscar Zaragoza

Description : Azole resistance is an emerging problem in Aspergillus which impacts the management of aspergillosis. Here in we report the emergence and clonal spread of resistance to triazoles in environmental Aspergillus fumigatus isolates in India. A total of 44 (7%) A. fumigatus isolates from 24 environmental samples were found to be triazole resistant. The isolation rate of resistant A. fumigatus was highest (33%) from soil of tea gardens followed by soil from flower...

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Plos One : Fixation Strategy Influences the Ability to Focus Atten...

By: Suliann Ben Hamed

Description : The ability to devote attention simultaneously to multiple visual objects plays an important role in domains ranging from everyday activities to the workplace. Yet, no studies have systematically explored the fixation strategies that optimize attention to two spatially distinct objects. Assuming the two objects require attention nearly simultaneously, subjects either could fixate one object or they could fixate between the objects. Studies measuring the bre...

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Plos One : Hepatitis C Viremia is Associated with Cytomegalovirus ...

By: Julian W. Tang

Description : CMV IgG levels are higher in HCV/HIV co-infected women than in HIV mono-infected women. Further research on the association of HCV with CMV IgG is indicated because prior studies have found CMV IgG to be associated with morbidity and mortality in the general population and subclinical carotid artery disease in HIV-infected patients.

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Plos One : Activation of Cd11B+ Kupffer Cells, Volume 7

By: Roland Lang

Description : We have reported that the mouse hepatic injury induced by either a-galactosylceramide (a-GalCer) or bacterial DNA motifs (CpG-ODN) is mediated by the TNF/NKT cell/Fas-ligand (FasL) pathway. In addition, F4/80+ Kupffer cells can be subclassified into CD68+ subset with a phagocytosing capacity and CD11b+ subset with a TNF-producing capacity. CD11b+ subset increase if mice are fed high-fat and cholesterol diet (HFCD). The present study examined how a HFCD affe...

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Plos One : Postpartum Haemorrhage in Canada and France ; a Populat...

By: Martin Gerbert Frasch

Description : PPH incidence was not higher in France than in Canada and there was no substantial difference in PPH risk factors between the 2 countries. Greater use of second-line treatments in PPH management in France suggests a more frequent failure of first-line treatments and a higher rate of severe PPH, which may be involved in the higher maternal mortality ratio due to PPH.

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Plos One : Hypoxia Modulates Fibroblastic Architecture, Adhesion a...

By: Surinder K. Batra

Description : Cells can adapt to hypoxia by various mechanisms. Yet, hypoxia-induced effects on the cytoskeleton-based cell architecture and functions are largely unknown. Here we present a comprehensive analysis of the architecture and function of L929 fibroblasts under hypoxic conditions (1% O2). Cells cultivated in hypoxia showed striking morphological differences as compared to cells cultivated under normoxic conditions (20% O2). These changes include an enlargement ...

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Plos One : a Randomized Controlled Trial Evaluating a Manualized T...

By: Marianna Mazza

Description : TeleCoach produced significantly greater adherence to moodManager, relative to self-directed moodManager. TeleCoached moodManager produced greater reductions in depressive symptoms relative to WLC, however, there were no statistically significant differences relative to self-directed moodManager. While greater use was associated with better outcomes, most users in both TeleCoach and self-directed moodManager had dropped out of treatment by week 12. Even wit...

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Plos One : Small Gtpase Rab40C Associates with Lipid Droplets and ...

By: Clarissa Menezes Maya-monteiro

Description : The subcellular location and cell biological function of small GTPase Rab40c in mammalian cells have not been investigated in detail. In this study, we demonstrated that the exogenously expressed GFP-Rab40c associates with lipid droplets marked by neutral lipid specific dye Oil red or Nile red, but not with the Golgi or endosomal markers. Further examination demonstrated that Rab40c is also associated with ERGIC-53 containing structures, especially under th...

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Plos One : Loss of the Keratin Cytoskeleton is Not Sufficient to I...

By: Victoria Lawson

Description : Epithelial-to-mesenchymal transition (EMT), the phenotypical change of cells from an epithelial to a mesenchymal type, is thought to be a key event in invasion and metastasis of adenocarcinomas. These changes involve loss of keratin expression as well as loss of cell polarity and adhesion. We here aimed to determine whether the loss of keratin expression itself drives increased invasion and metastasis in adenocarcinomas and whether keratin loss leads to the...

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Plos One : Proteolytic Characteristics of Cathepsin D Related to t...

By: Sonja Hess

Description : Cathepsin D (CD) plays an important role in both biological and pathological processes, although the cleavage characteristics and substrate selection of CD have yet to be fully explored. We employed liquid chromatography-tandem mass spectrometry (LC-MS/MS) to identify the CD cleavage sites in bovine serum albumin (BSA). We found that the hydrophobic residues at P1 were not only a preferential factor for CD cleavage but that the hydrophobicity at P1’ also co...

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Plos One : an Outbreak of Human Fascioliasis Gigantica in Southwes...

By: Martyn Kirk

Description : Fascioliasis is a common parasitic disease in livestock in China. However, human fascioliasis is rarely reported in the country. Here we describe an outbreak of human fascioliasis in Yunnan province. We reviewed the complete clinical records of 29 patients and performed an epidemiological investigation on the general human population and animals in the outbreak locality. Our findings support an outbreak due to Fasciola gigantica with a peak in late November...

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