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Plos One : Stability of Whole Brain and Regional Network Topology ...

By: Wang Zhan

Description : These findings suggest that network topology is fairly stable within individuals across time for the same state, but also fluid between states. Whole brain voxel-based network analyses may prove to be a valuable tool for exploring how functional connectivity changes in response to task demands.

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Plos One : Rab11 Plays an Indispensable Role in the Differentiatio...

By: Shree Ram Singh

Description : Rab11, an evolutionary conserved, ubiquitously expressed subfamily of small monomeric GTPase has been known to regulate diverse cellular and developmental events, by regulating the exocytotic and transcytotic events inside the cell. Our studies show that Rab11 regulates Drosophila adult myogenesis by controlling proliferation and differentiation of the Adult muscle precursors (AMPs). Blocking Rab11 in the AMPs, which fuse to form the Indirect Flight Muscles...

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Plos One : Ectopic Expression of Hrf1 Enhances Bacterial Resistanc...

By: Keqiang Wu

Description : Harpin proteins as elicitor derived from plant gram negative bacteria such as Xanthomonas oryzae pv. oryzae (Xoo), Erwinia amylovora induce disease resistance in plants by activating multiple defense responses. However, it is unclear whether phytoalexin production and ROS burst are involved in the disease resistance conferred by the expression of the harpinXoo protein in rice. In this article, ectopic expression of hrf1 in rice enhanced resistance to bacter...

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Plos One : Challenges in the Diagnosis of Iron Deficiency in Child...

By: Amanda Bruce

Description : Iron deficiency by bone marrow examination was extremely frequent in these children exposed to high prevalence of infections. However, even the best markers of bone marrow iron deficiency did not identify around a quarter of iron-deficient children. Tough not directly extrapolated to the community, these findings urge for more reliable, affordable and easy to measure iron indicators to reduce the burden of iron deficiency anaemia in resource-poor settings w...

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Plos One : Trip Database 2.0 ; a Manually Curated Information Hub ...

By: Agustin Guerrero-hernandez

Description : Transient receptor potential (TRP) channels are a family of Ca2+-permeable cation channels that play a crucial role in biological and disease processes. To advance TRP channel research, we previously created the TRIP (TRansient receptor potential channel-Interacting Protein) Database, a manually curated database that compiles scattered information on TRP channel protein-protein interactions (PPIs). However, the database needs to be improved for information ...

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Plos One : Benchmarking Human Protein Complexes to Investigate Dru...

By: Ozlem Keskin

Description : Protein complexes are key entities to perform cellular functions. Human diseases are also revealed to associate with some specific human protein complexes. In fact, human protein complexes are widely used for protein function annotation, inference of human protein interactome, disease gene prediction, and so on. Therefore, it is highly desired to build an up-todate catalogue of human complexes to support the research in these applications. Protein complexes...

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Plos One : Peripheral Blood Cell Signatures of Plasmodium Falcipar...

By: Carlos Penha-goncalves

Description : Sequestration of Plasmodium falciparum-infected erythrocytes in placental intervillous spaces causes inflammation and pathology. Knowledge of the profiles of immune cells associated with the physiopathology of pregnancy-associated malaria (PAM) is scarce. We conducted a longitudinal, prospective study, both in Benin and Tanzania, including ,1000 pregnant women in each site with systematic follow-up at scheduled antenatal visits until delivery. We used ex vi...

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Plos One : Induction of Encephalitis in Rhesus Monkeys Infused wit...

By: Robyn Klein

Description : The overlapping epidemiology of multiple sclerosis (MS) and Epstein-Barr virus (EBV), the increased risk to develop MS after infectious mononucleosis (IM) and the localization of EBV-infected B-cells within the MS brain suggest a causal link between EBV and MS. However, the underlying mechanism is unknown. We hypothesize that EBV-infected B-cells are capable of eliciting a central nervous system (CNS) targeting autoimmune reaction. To test this hypothesis w...

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Plos One : Two-component System Response Regulators Involved in Vi...

By: Indranil Biswas

Description : Streptococci resident in the oral cavity have been linked to infective endocarditis (IE). While other viridans streptococci are commonly studied in relation to IE, less research has been focused on Streptococcus pneumoniae. We established for the first time an animal model of S. pneumoniae IE, and examined the virulence of the TIGR4 strain in this model. We hypothesized that two-component systems (TCS) may mediate S. pneumoniae TIGR4 strain virulence in IE ...

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Plos One : Functional Analysis of Pgrp-la in Drosophila Immunity, ...

By: Fran├žois Leulier

Description : PeptidoGlycan Recognition Proteins (PGRPs) are key regulators of the insect innate antibacterial response. Even if they have been intensively studied, some of them have yet unknown functions. Here, we present a functional analysis of PGRP-LA, an as yet uncharacterized Drosophila PGRP. The PGRP-LA gene is located in cluster with PGRP-LC and PGRP-LF, which encode a receptor and a negative regulator of the Imd pathway, respectively. Structure predictions indic...

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Plos One : Comparative Analysis of Dna Nanoparticles and Aavs for ...

By: Alexander V. Ljubimov

Description : Gene therapy is a critical tool for the treatment of monogenic retinal diseases. However, the limited vector capacity of the current benchmark delivery strategy, adeno-associated virus (AAV), makes development of larger capacity alternatives, such as compacted DNA nanoparticles (NPs), critical. Here we conduct a side-by-side comparison of self-complementary AAV and CK30PEG NPs using matched ITR plasmids. We report that although AAVs are more efficient per v...

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Plos One : Tnfaip3Gene Polymorphisms in a Chinese Han Population w...

By: Ali Torkamani

Description : The results suggest that the rs9494885 TC genotype and C allele may be predisposing factors to VKH disease, whereas the rs9494885 TT genotype and T allele may provide protection against this disease.

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Plos One : Serum Ape1 Autoantibodies ; a Novel Potential Tumor Mar...

By: Hiromu Suzuki

Description : Apurinic/apyrimidinic endonuclease 1 (APE1), which has the dual functions of both DNA repair and redox activity, has been reported to be highly expressed in non-small cell lung cancer (NSCLC), and this appears to be a characteristic related to chemotherapy resistance. In this study, we identified serum APE1 autoantibodies (APE1-AAbs) in NSCLC patients and healthy controls by immunoblotting and investigated the expression of APE1-AAbs by indirect ELISA from ...

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Plos One : Therapeutic Hypothermia for Neonatal Encephalopathy in ...

By: Olivier Baud

Description : Cooling therapy was not associated with a statistically significant reduction in neonatal mortality in low-and middle-income countries although the confidence intervals were wide and not incompatible with results seen in highincome countries. The apparent lack of treatment effect may be due to the heterogeneity and poor quality of the included studies, inefficiency of the low technology cooling devices, lack of optimal neonatal intensive care, sedation and ...

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Plos One : Presence of a Polymicrobial Endometrial Biofilm in Pati...

By: Adam J. Ratner

Description : Bacterial vaginosis is frequently associated with the presence of a structured polymicrobial Gardnerella vaginalis biofilm attached to the endometrium. This may have major implications for our understanding of the pathogenesis of adverse pregnancy outcome in association with bacterial vaginosis.

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Plos One : Multimodal Treatment Eliminates Cancer Stem Cells and L...

By: This Multimodal Therapeutic Strategy Should Be Further Explored in the Clinical Setting as Its Success May

Description : This multimodal therapeutic strategy should be further explored in the clinical setting as its success may eventually improve the poor prognosis of patients with pancreatic ductal adenocarcinoma.

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Plos One : Adoptive Transfer of Regulatory T Cells Protects Agains...

By: Tianqing Peng

Description : Our data suggested that Tregs have a protective role in the fibrotic process of CVB3- induced cardiac fibrosis via secreting IL-10 and might provide an alternative option for the future treatment of cardiac fibrosis.

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Plos One : Establishment of Immortalized Human Erythroid Progenito...

By: Tadeu Dimas Covas

Description : Transfusion of red blood cells (RBCs) is a standard and indispensable therapy in current clinical practice. In vitro production of RBCs offers a potential means to overcome a shortage of transfusable RBCs in some clinical situations and also to provide a source of cells free from possible infection or contamination by microorganisms. Thus, in vitro production of RBCs may become a standard procedure in the future. We previously reported the successful establ...

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Plos One : Superior Cross-species Reference Genes ; a Blueberry Ca...

By: Randall P. Niedz

Description : The advent of affordable Next Generation Sequencing technologies has had major impact on studies of many crop species, where access to genomic technologies and genome-scale data sets has been extremely limited until now. The recent development of genomic resources in blueberry will enable the application of high throughput gene expression approaches that should relatively quickly increase our understanding of blueberry physiology. These studies, however, re...

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Plos One : Biological Mechanisms Underlying Structural Changes Ind...

By: Anthony W.I. Lo

Description : We previously reported the utility of Low-Coherence Enhanced Backscattering (LEBS) Spectroscopy in detecting optical changes in uninvolved rectal mucosa, changes that are indicative of the presence of advanced colorectal adenomas elsewhere in the colon (field carcinogenesis). We hypothesized that the alterations in optical signatures are due to structural changes in colonocytes. To elucidate those colonocyte changes, we used LEBS and an early time point in ...

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