World Library  


 
  • Cover Image

Plos Biology : Parallel Evolution of the Genetic Code in Arthropod...

By: David Hillis

Description : The genetic code provides the translation table necessary to transform the information contained in DNA into the language of proteins. In this table, a correspondence between each codon and each amino acid is established : tRNA is the main adaptor that links the two. Although the genetic code is nearly universal, several variants of this code have been described in a wide range of nuclear and organellar systems, especially in metazoan mitochondria. These va...

Read More
  • Cover Image

Plos Biology : Generation of Healthy Mice from Gene-corrected Dise...

By: Margaret A. Goodell

Description : Using the murine model of tyrosinemia type 1 (fumarylacetoacetate hydrolase [FAH] deficiency: FAH2/2 mice) as a paradigm for orphan disorders, such as hereditary metabolic liver diseases, we evaluated fibroblast-derived FAH2/2-induced pluripotent stem cells (iPS cells) as targets for gene correction in combination with the tetraploid embryo complementation method. First, after characterizing the FAH2/2 iPS cell lines, we aggregated FAH2/2-iPS cells with tet...

Read More
  • Cover Image

Plos Biology : a Blossoming Field of Research ; How Florigen is Tr...

By: Public Library of Science (Plos)
Read More
  • Cover Image

Plos Biology : Humans Lack Igb3 Due to the Absence of Functional I...

By: Dale Christiansen

Description : The glycosphingolipid isoglobotrihexosylceramide, or isogloboside 3 (iGb3), is believed to be critical for natural killer T (NKT) cell development and self-recognition in mice and humans. Furthermore, iGb3 may represent an important obstacle in xenotransplantation, in which this lipid represents the only other form of the major xenoepitope Gala(1,3)Gal. The role of iGb3 in NKT cell development is controversial, particularly with one study that suggested tha...

Read More
  • Cover Image

Plos Biology : Neuroscience, Ethics, and National Security ; the S...

By: Jonathan D. Moreno

Description : National security organizations in the United States, including the armed services and the intelligence community, have developed a close relationship with the scientific establishment. The latest technology often fuels warfighting and counter-intelligence capacities, providing the tactical advantages thought necessary to maintain geopolitical dominance and national security. Neuroscience has emerged as a prominent focus within this milieu, annually receivi...

Read More
  • Cover Image

Plos Biology : Segment-specific Neuronal Subtype Specification by ...

By: William A. Harris

Description : The generation of distinct neuronal subtypes at different axial levels relies upon both anteroposterior and temporal cues. However, the integration between these cues is poorly understood. In the Drosophila central nervous system, the segmentally repeated neuroblast 5–6 generates a unique group of neurons, the Apterous (Ap) cluster, only in thoracic segments. Recent studies have identified elaborate genetic pathways acting to control the generation of these...

Read More
  • Cover Image

Plos Biology : Rapid De Novo Evolution of X Chromosome Dosage Comp...

By: Detlef Weigel

Description : Silene latifolia is a dioecious plant with heteromorphic sex chromosomes that have originated only ,10 million years ago and is a promising model organism to study sex chromosome evolution in plants. Previous work suggests that S. latifolia XY chromosomes have gradually stopped recombining and the Y chromosome is undergoing degeneration as in animal sex chromosomes. However, this work has been limited by the paucity of sex-linked genes available. Here, we u...

Read More
  • Cover Image

Plos Biology : Recognition and Degradation of Plant Cell Wall Poly...

By: Jonathan A. Eisen

Description : Symbiotic bacteria inhabiting the human gut have evolved under intense pressure to utilize complex carbohydrates, primarily plant cell wall glycans in our diets. These polysaccharides are not digested by human enzymes, but are processed to absorbable short chain fatty acids by gut bacteria. The Bacteroidetes, one of two dominant bacterial phyla in the adult gut, possess broad glycan-degrading abilities. These species use a series of membrane protein complex...

Read More
  • Cover Image

Plos Biology : Genetic Mismatches Between Nuclei and Mitochondria ...

By: Robin Meadows
Read More
  • Cover Image

Plos Biology : Functional Genomics Thickens the Biological Plot, V...

By: Virginia Gewin
Read More
  • Cover Image

Plos Biology : Ubiquitylation in Erad ; Reversing to Go Forward, V...

By: Allan M. Weissman
Read More
  • Cover Image

Plos Biology : Β1 Integrin Maintains Integrity of the Embryonic Ne...

By: Franck Polleux

Description : During embryogenesis, the neural stem cells (NSC) of the developing cerebral cortex are located in the ventricular zone (VZ) lining the cerebral ventricles. They exhibit apical and basal processes that contact the ventricular surface and the pial basement membrane, respectively. This unique architecture is important for VZ physical integrity and fate determination of NSC daughter cells. In addition, the shorter apical process is critical for interkinetic nu...

Read More
  • Cover Image

Plos Biology : Dual Role of Topoisomerase II in Centromere Resolut...

By: Paula A. Coelho

Description : Chromosome segregation requires sister chromatid resolution. Condensins are essential for this process since they organize an axial structure where topoisomerase II can work. How sister chromatid separation is coordinated with chromosome condensation and decatenation activity remains unknown. We combined four-dimensional (4D) microscopy, RNA interference (RNAi), and biochemical analyses to show that topoisomerase II plays an essential role in this process. ...

Read More
  • Cover Image

Plos Biology : Midline Signalling Systems Direct the Formation of ...

By: Rachel O. L. Wong

Description : A fundamental strategy for organising connections in the nervous system is the formation of neural maps. Map formation has been most intensively studied in sensory systems where the central arrangement of axon terminals reflects the distribution of sensory neuron cell bodies in the periphery or the sensory modality. This straightforward link between anatomy and function has facilitated tremendous progress in identifying cellular and molecular mechanisms tha...

Read More
  • Cover Image

Plos Biology : Unanticipated Antigens ; Translation Initiation at ...

By: Marc Jenkins

Description : Major histocompatibility class I molecules display tens of thousands of peptides on the cell surface for immune surveillance by T cells. The peptide repertoire represents virtually all cellular translation products, and can thus reveal a foreign presence inside the cell. These peptides are derived from not only conventional but also cryptic translational reading frames, including some without conventional AUG codons. To define the mechanism that generates t...

Read More
  • Cover Image

Plos Biology : Light, Sleep, and Circadian Rhythms ; Together Agai...

By: Derk-jan Dijk
Read More
  • Cover Image

Plos Biology : Dynamics of Snare Assembly and Disassembly During S...

By: Fred Hughson

Description : The dynamics of SNARE assembly and disassembly during membrane recognition and fusion is a central issue in intracellular trafficking and regulated secretion. Exocytosis of sperm’s single vesicle—the acrosome—is a synchronized, all-or-nothing process that happens only once in the life of the cell and depends on activation of both the GTP-binding protein Rab3 and of neurotoxin-sensitive SNAREs. These characteristics make acrosomal exocytosis a unique mammali...

Read More
  • Cover Image

Plos Biology : Institutional Open Access Funds ; Now is the Time, ...

By: Charles D. Eckman
Read More
  • Cover Image

Plos Biology : Bimodal Control of Dendritic and Axonal Growth by t...

By: Franck Polleux

Description : Knowledge of the molecular and genetic mechanisms underlying the separation of dendritic and axonal compartments is not only crucial for understanding the assembly of neural circuits, but also for developing strategies to correct defective dendrites or axons in diseases with subcellular precision. Previous studies have uncovered regulators dedicated to either dendritic or axonal growth. Here we investigate a novel regulatory mechanism that differentially di...

Read More
  • Cover Image

Plos Biology : Systematic Discovery of New Recognition Peptides Me...

By: Rowena Matthews

Description : Many aspects of cell signalling, trafficking, and targeting are governed by interactions between globular protein domains and short peptide segments. These domains often bind multiple peptides that share a common sequence pattern, or ‘‘linear motif’’ (e.g., SH3 binding to PxxP). Many domains are known, though comparatively few linear motifs have been discovered. Their short length (three to eight residues), and the fact that they often reside in disordered ...

Read More
 
1
|
2
|
3
Records: 1 - 20 of 45 - Pages: 



Copyright © World Library Foundation. All rights reserved. eBooks from World Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.