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Plos One : a Recombinant Fusion Toxin Based on Enzymatic Inactive ...

By: Michel R. Popoff

Description : In summary, we demonstrated that C3bot1E174Q can be used as a delivery system for fast, selective and specific transport of enzymes into the cytosol of living macrophages. Therefore, C3-based fusion toxins can represent valuable molecular tools in experimental macrophage pharmacology and cell biology as well as attractive candidates to develop new therapeutic approaches against macrophage-associated diseases.

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Plos One : Transcriptome Sequences Resolve Deep Relationships of t...

By: Hector Candela

Description : Previous phylogenetic studies of the grape family (Vitaceae) yielded poorly resolved deep relationships, thus impeding our understanding of the evolution of the family. Next-generation sequencing now offers access to protein coding sequences very easily, quickly and cost-effectively. To improve upon earlier work, we extracted 417 orthologous single-copy nuclear genes from the transcriptomes of 15 species of the Vitaceae, covering its phylogenetic diversity....

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Plos One : on the Relevance of Sophisticated Structural Annotation...

By: Narcis Fernandez-fuentes

Description : Disulfide bridges strongly constrain the native structure of many proteins and predicting their formation is therefore a key sub-problem of protein structure and function inference. Most recently proposed approaches for this prediction problem adopt the following pipeline : first they enrich the primary sequence with structural annotations, second they apply a binary classifier to each candidate pair of cysteines to predict disulfide bonding probabilities a...

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Plos One : Characterization and Prevention of the Adsorption of Su...

By: Dominik Hartl

Description : Surfactant Protein D (SP-D) is a multifunctional protein present in the lung and in respiratory secretions. In the process of developing new experimental approaches to examine SP-D function, we observed that SP-D adsorbs to polypropylene tubes to a great extent, thereby depleting SP-D from the solution. Although it is well known that proteins adsorb nonspecifically to plastic, this effect is usually diminished by treatments to make the plastic ‘‘low-retenti...

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Plos One : CA2+-activated Cl- Channels of the Clca Family Express ...

By: Johannes Reisert

Description : The Ca2+-activated Cl2 channel is considered a key constituent of odor transduction. Odorant binding to a specific receptor in the cilia of olfactory sensory neurons (OSNs) triggers a cAMP cascade that mediates the opening of a cationic cyclic nucleotide-gated channel (CNG), allowing Ca2+ influx. Ca2+ ions activate Cl2 channels, generating a significant Cl2 efflux, with a large contribution to the receptor potential. The Anoctamin 2 channel (ANO2) is a majo...

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Plos One : Jarid1A, Jmy, and Ptger4 Polymorphisms Are Related to A...

By: Graham R. Wallace

Description : Susceptibility to ankylosing spondylitis (AS) is largely genetically determined. JARID1A, JMY and PTGER4 have recently been found to be associated with AS in patients of western European descent. We aim to examine the influence of JARID1A, JMY, and PTGER4 polymorphisms on the susceptibility to and the severity of ankylosing spondylitis in Chinese ethnic majority Han population. This work can lead the clinical doctors to intervene earlier. Blood samples were...

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Plos One : the Hopq1 Effector’s Nucleoside Hydrolase-like Domain i...

By: Boris Vinatzer Alexander

Description : Bacterial pathogens deliver multiple effector proteins into host cells to facilitate bacterial growth. HopQ1 is an effector from Pseudomonas syringae pv. tomato DC3000 that is conserved across multiple bacterial pathogens which infect plants. HopQ1’s central region possesses some homology to nucleoside hydrolases, but possesses an alternative aspartate motif not found in characterized enzymes. A structural model was generated for HopQ1 based on the E. coli ...

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Plos One : Bortezomib-induced Painful Peripheral Neuropathy ; an E...

By: Theodore John Price

Description : this study extends the knowledge of the sites of damage induced in the nervous system by bortezomib administration. Moreover, a selective functional vulnerability of peripheral nerve fiber subpopulations was found as well as a change in the electrical activity of wide dynamic range neurons of dorsal horn of spinal cord. Finally, the immune response is not a key factor in the development of morphological and functional damage induced by bortezomib in the peripheral nervous system.

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Plos One : the Possible Role of Resource Requirements and Academic...

By: Matjaz Perc

Description : Many studies demonstrate that there is still a significant gender bias, especially at higher career levels, in many areas including science, technology, engineering, and mathematics (STEM). We investigated field-dependent, gender-specific effects of the selective pressures individuals experience as they pursue a career in academia within seven STEM disciplines. We built a unique database that comprises 437,787 publications authored by 4,292 faculty members ...

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Plos One : Automated Objective Routine Examination of Optical Qual...

By: P. James Brody

Description : Rigid endoscopes degrade during clinical use due to sterilization, ionizing radiation and mechanical forces. Despite visual checks on functionality at the department of sterilization, surgeons are still confronted with suboptimal instruments as it is difficult to assess this degradation in an objective manner. To guarantee that endoscopes have sufficient optical quality for minimal invasive surgery, an experimental opto-electronic test bench has been develo...

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Plos One : a Superfamily of Dna Transposons Targeting Multicopy Sm...

By: Akio Kanai

Description : Target-specific integration of transposable elements for multicopy genes, such as ribosomal RNA and small nuclear RNA (snRNA) genes, is of great interest because of the relatively harmless nature, stable inheritance and possible application for targeted gene delivery of target-specific transposable elements. To date, such strict target specificity has been observed only among non-LTR retrotransposons. We here report a new superfamily of sequence-specific DN...

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Plos One : Mir-snps as Markers of Toxicity and Clinical Outcome in...

By: Aamir Ahmed

Description : miR-SNPs can add useful prognostic information on treatment-related toxicity and clinical outcome in Hodgkin lymphoma and can be used to identify patients likely to be chemoresistant or to relapse.

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Plos One : Maintenance of Coastal Surface Blooms by Surface Temper...

By: Inés Álvarez

Description : Algae blooms are an increasingly recurrent phenomenon of potentially socio-economic impact in coastal waters globally and in the coastal upwelling region off northern Baja California, Mexico. In coastal upwelling areas the diurnal wind pattern is directed towards the coast during the day. We regularly found positive Near Surface Temperature Stratification (NSTS), the resulting density stratification is expected to reduce the frictional coupling of the surfa...

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Plos One : Mechanisms of Color Production in a Highly Variable Shi...

By: Kevin McGraw

Description : Theory suggests that aposematism, specifically the learned avoidance of unprofitable prey via memorable color patterns, should result in selection for pattern uniformity. However, many examples to the contrary are seen in nature. Conversely, honest sexual signals are likely to exhibit greater variation because they reflect underlying variation in mate quality. Here we aim to characterize and quantify the mechanistic causes of color in Tectocoris diopthalmus...

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Plos One : Tanned or Burned ; the Role of Fire in Shaping Physical...

By: Francesco De Bello

Description : Plant species with physical seed dormancy are common in mediterranean fire-prone ecosystems. Because fire breaks seed dormancy and enhances the recruitment of many species, this trait might be considered adaptive in fire-prone environments. However, to what extent the temperature thresholds that break physical seed dormancy have been shaped by fire (i.e., for post-fire recruitment) or by summer temperatures in the bare soil (i.e., for recruitment in fire-in...

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Plos One : Development of a New Approach to Aid in Visual Identifi...

By: Alysson Renato Muotri

Description : The a priori identification of induced pluripotent stem cells remains a challenge. Being able to quickly identify the most embryonic stem cell-similar induced pluripotent stem cells when validating results could help to reduce costs and save time. In this context, tools based on non-classic logic can be useful in creating aid-systems based on visual criteria. True colonies when viewed at 100x magnification have been found to have the following 3 characteris...

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Plos One : Twelve-month-olds’ Understanding of Intention Transfer ...

By: Andrew Bremner

Description : Do infants understand that intention can be transferred through communication? We answered this question by examining 12-month-olds’ looking times in a violation-of-expectation paradigm with two human agents. In familiarization, the nonacting agent spoke, clapped her hands, read aloud a book, or remained silent before the acting agent grasped one (the target) of two objects. During test only the non-actor remained, grasping either the target or distractor. ...

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Plos One : Comparative Genomics of Multiple Strains of Pseudomonas...

By: Eric Cascales

Description : Comparative genomics of closely related pathogens that differ in host range can provide insights into mechanisms of hostpathogen interactions and host adaptation. Furthermore, sequencing of multiple strains with the same host range reveals information concerning pathogen diversity and the molecular basis of virulence. Here we present a comparative analysis of draft genome sequences for four strains of Pseudomonas cannabina pathovar alisalensis (Pcal), which...

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Plos One : Altered Expression of 14-3-3F Protein in Spinal Cords o...

By: Kwang-hyun Baek

Description : These data suggest that the reduced expression of 14-3-3f plays a role in the excessive apoptosis that occurs in spina bifida and may be partly regulated by the over-expression of miR-451 and miR-375, and the consequent up-regulation of p53 might further promote apoptosis in spina bifida.

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Plos One : the Clinical Significance of Vitamin D in Systemic Lupu...

By: Paul Proost

Description : There is convincing evidence to support the association between vitamin D levels and SLE disease activity. There is paucity of data in other clinical aspects to make firm conclusions.

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