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Plos One : Transcriptional Regulation of Htrex84 in Human Cancer C...

By: Lin Zhang

Description : TREX (transcription/export) is a multiprotein complex that plays a key role in the transcriptional elongation and transport of mRNA from the nucleus to the cytoplasm. We previously reported the purification of the human TREX protein and found that expression of a member of this complex, p84N5 (referred to as hTREX84 or hHPR1), a RB binding protein, correlated with breast tumor size and metastasis. Here we examine the mechanisms of aberrant expression of hTR...

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Plos One : Direct Interaction of Selenoprotein R with Clusterin an...

By: Riqiang Yan

Description : Selenoprotein R (SelR) plays an important role in maintaining intracellular redox balance by reducing the R-form of methionine sulfoxide to methionine. As SelR is highly expressed in brain and closely related to Alzheimer9s disease (AD), its biological functions in human brain become a research focus. In this paper, the selenocysteine-coding TGA of SelR gene was mutated to cysteine-coding TGC and used to screen the human fetal brain cDNA library with a yeas...

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Plos One : a Truncated Ades Kinase Protein Generated by is Aba1 In...

By: Mark Alexander Webber

Description : Over-expression of AdeABC efflux pump stimulated continuously by the mutated AdeRS two component system has been found to result in antimicrobial resistance, even tigecycline (TGC) resistance, in multidrug-resistant Acinetobacter baumannii (MRAB). Although the insertion sequence, ISAba1, contributes to one of the AdeRS mutations, the detail mechanism remains unclear. In the present study we collected 130 TGC-resistant isolates from 317 carbapenem resistant ...

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Plos One : Dissociable Effects of Sry and Sex Chromosome Complemen...

By: Eric M Mintz

Description : Whilst gonadal hormones can substantially influence sexual differentiation of the brain, recent findings have suggested that sex-linked genes may also directly influence neurodevelopment. Here we used the well-established murine ‘four core genotype’ (FCG) model on a gonadally-intact, outbred genetic background to characterise the contribution of Sry-dependent effects (i.e. those arising from the expression of the Y-linked Sry gene in the brain, or from horm...

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Plos One : Fecal Lipocalin 2, a Sensitive and Broadly Dynamic Non-...

By: Stefan Bereswill

Description : Inflammation has classically been defined histopathologically, especially by the presence of immune cell infiltrates. However, more recent studies suggest a role for low-grade inflammation in a variety of disorders ranging from metabolic syndrome to cancer, which is defined by modest elevations in pro-inflammatory gene expression. Consequently, there is a need for cost-effective, non-invasive biomarkers that, ideally, would have the sensitivity to detect lo...

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Plos One : Partially Silencing Brain Toll-like Receptor 4 Prevents...

By: Hiranmoy Das

Description : Partially silencing brain TLR4 by ICV injection of TLR4-SiRNA for 2 weeks could in part prevent LV remodeling with sympathoinhibition in rats with MI-induced heart failure. Brain TLR4 has a potential to be a target of the treatment for MI-induced heart failure.

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Plos One : Determinants of Arterial Stiffness in Chronic Kidney Di...

By: Murielle Bochud

Description : In this cohort, age and traditional CV risk factors were the strongest determinants of AS. Albuminuria was a relatively weak determinant of AS and eGFR was not an independent determinant. Long-term follow-up will investigate AS as an independent risk factor for CVE in this cohort.

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Plos One : Increasing Transfers-out from an Antiretroviral Treatme...

By: Matthew P. Fox

Description : With scale-up of ART over time, an increasing proportion of patients are transferring between ART services and information systems are needed to track patients. Approximately one-fifth of these have viral loads .1000 copies/mL around the time of transfer, suggesting the need for careful adherence counseling and assessment of medication supplies among those planning transfer.

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Plos One : Comparison Between Internalizing Anti-her2 Mabs and Non...

By: Bart O. Williams

Description : These data indicate that it might be an advantage of using internalizing anti-HER2 compared with noninternalizing anti-CEA 212Pb-labeled mAbs in the therapy of small volume xenograft tumors. They support clinical investigations of 212Pb-mAbs RIT as an adjuvant treatment after cytoreductive surgery in patients with peritoneal carcinomatosis.

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Plos One : Bumblebee Venom Serine Protease Increases Fungal Insect...

By: Alfredo Herrera-estrella

Description : Insect-killing (entomopathogenic) fungi have high potential for controlling agriculturally harmful pests. However, their pathogenicity is slow, and this is one reason for their poor acceptance as a fungal insecticide. The expression of bumblebee, Bombus ignitus, venom serine protease (VSP) by Beauveria bassiana (ERL1170) induced melanization of yellow spotted longicorn beetles (Psacothea hilaris) as an over-reactive immune response, and caused substantially...

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Plos One : a Unified Framework Integrating Parent-of-origin Effect...

By: Rongling Wu

Description : Genetic imprinting is the most well-known cause for parent-of-origin effect (POE) whereby a gene is differentially expressed depending on the parental origin of the same alleles. Genetic imprinting is related to several human disorders, including diabetes, breast cancer, alcoholism, and obesity. This phenomenon has been shown to be important for normal embryonic development in mammals. Traditional association approaches ignore this important genetic phenome...

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Plos One : Integrative Binding Sites Within Intracellular Termini ...

By: Alexander G. Obukhov

Description : TRPV1 is a nonselective cation channel that integrates wide range of painful stimuli. It has been shown that its activity could be modulated by intracellular ligands PIP2 or calmodulin (CaM). The detailed localization and description of PIP2 interaction sites remain unclear. Here, we used synthesized peptides and purified fusion proteins of intracellular regions of TRPV1 expressed in E.coli in combination with fluorescence anisotropy and surface plasmon res...

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Plos One : Neem Leaf Glycoprotein Activates Cd8+ T Cells to Promot...

By: Kim J. Hasenkrug

Description : In spite of sufficient data on Neem Leaf Glycoprotein (NLGP) as a prophylactic vaccine, little knowledge currently exists to support the use of NLGP as a therapeutic vaccine. Treatment of mice bearing established sarcomas with NLGP (25 mg/mice/ week subcutaneously for 4 weeks) resulted in tumor regression or dormancy (Tumor free/Regressor, 13/24 (NLGP), 4/24 (PBS)). Evaluation of CD8+ T cell status in blood, spleen, TDLN, VDLN and tumor revealed increase in...

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Plos One : Fty720 Treatment in the Convalescence Period Improves F...

By: Christoph Kleinschnitz

Description : Besides its known neuroprotective effects in the acute phase of experimental stroke, the initiation of FTY720 treatment in the convalescence period has a positive impact on long-term functional outcome, probably mediated through reduced astrogliosis, a modulation in synaptic morphology and an increased expression of neurotrophic factors.

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Plos One : Novel Associations of Vkorc1Variants with Higher Acenoc...

By: Tom R. Gaunt

Description : Our strategy identified novel associations of VKORC1 variants with higher acenocoumarol doses albeit with a low effect size. Further studies are necessary to test their influence on the VKORC1 function and the cost/benefit of their inclusion in pharmacogenetic algorithms.

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Plos One : Visual Search in Ecological and Non-ecological Displays...

By: Adrian G Dyer

Description : Considerable research has been carried out on visual search, with single or multiple targets. However, most studies have used artificial stimuli with low ecological validity. In addition, little is known about the effects of target complexity and expertise in visual search. Here, we investigate visual search in three conditions of complexity (detecting a king, detecting a check, and detecting a checkmate) with chess players of two levels of expertise (novic...

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Plos One : the Cytokine Ciliary Neurotrophic Factor Cntf Activates...

By: Hubert Vaudry

Description : Ciliary neurotrophic factor (CNTF) induces neurogenesis, reduces feeding, and induces weight loss. However, the central mechanisms by which CNTF acts are vague. We employed the mHypoE-20/2 line that endogenously expresses the CNTF receptor to examine the direct effects of CNTF on mRNA levels of urocortin-1, urocortin-2, agouti-related peptide, brainderived neurotrophic factor, and neurotensin. We found that treatment of 10 ng/ml CNTF significantly increased...

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Plos One : Tnf-like Weak Inducer of Apoptosis Tweak Promotes Beta ...

By: Kathrin Maedler

Description : We conclude that TWEAK is a novel factor mediating pancreatic b-cell neogenesis from ductal epithelium in normal adult mice

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Plos One : Aldose Reductase is Involved in the Development of Muri...

By: Hiroyasu Nakano

Description : Hepatic aldose reductase (AR) expression is known to be induced in liver diseases, including hepatitis and hepatocellular carcinoma. However, the role of AR in the development of these diseases remains unclear. We performed this current study to determine whether and how AR might be involved in the development of diet-induced nonalcoholic steatohepatitis. Our results showed that the level of AR protein expression was significantly higher in db/db mice fed t...

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Plos One : Su5416, a Vegf Receptor Inhibitor and Ligand of the Ahr...

By: Jose Carlos Alves-filho

Description : The experimental compound SU5416 went as far as Phase III clinical trials as an anticancer agent, putatively because of its activity as a VEGFR-2 inhibitor, but showed poor results. Here, we show that SU5416 is also an aryl hydrocarbon receptor (AHR) agonist with unique properties. Like TCDD, SU5416 favors induction of indoleamine 2,3 dioxygenase (IDO) in immunologically relevant populations such as dendritic cells in an AHR-dependent manner, leading to gen...

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