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Plos One : Altered Visual and Feet Proprioceptive Feedbacks During...

By: François Tremblay

Description : The results support that : (i) the postural reorganization under manipulation of the different sensory information is worse in obese KOA patients with severe degeneration and/or high pain intensity when compared with less impaired patients, and (ii) higher pain intensity is related to worse body balance in obese KOA patients.

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Plos One : New Insight Into Benign Tumours of Major Salivary Gland...

By: Rossella Rota

Description : Major salivary gland tumours are uncommon neoplasms of the head and neck. The increase of precise pre-operative diagnosis is crucial for their correct management and the identification of molecular markers would surely improve the required accuracy. In this study we performed a comparative proteomic analysis of fine needle aspiration fluids of the most frequent benign neoplasms of major salivary glands, namely pleomorphic adenoma and Warthin’s tumour, in or...

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Plos One : Using Gps Technology to Quantify Human Mobility, Dynami...

By: Vittoria Colizza

Description : Empiric quantification of human mobility patterns is paramount for better urban planning, understanding social network structure and responding to infectious disease threats, especially in light of rapid growth in urbanization and globalization. This need is of particular relevance for developing countries, since they host the majority of the global urban population and are disproportionally affected by the burden of disease. We used Global Positioning Syst...

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Plos One : Dendritic Cells from Crohn’s Disease Patients Show Aber...

By: Mathias Chamaillard

Description : Abnormalities of dendritic cells (DCs) and STAT proteins have been reported in Crohn’s disease (CD). Studies on JAK/STAT signaling in DCs are, however, lacking in CD. We applied a flowcytometric single-cell-based phosphoepitope assay to evaluate STAT1 and STAT3 pathways in DC subsets from CD patients. In addition, circulating DC counts were determined, together with the activation-related immunophenotype. We found that IL-6- and IFN-a-induced STAT3 phosphor...

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Plos One : Synaptic State Matching ; a Dynamical Architecture for ...

By: Suliann Ben Hamed

Description : Here we explore the possibility that a core function of sensory cortex is the generation of an internal simulation of sensory environment in real-time. A logical elaboration of this idea leads to a dynamical neural architecture that oscillates between two fundamental network states, one driven by external input, and the other by recurrent synaptic drive in the absence of sensory input. Synaptic strength is modified by a proposed synaptic state matching (SSM...

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Plos One : Ron Knockdown and Ron Monoclonal Antibody Imcron8 Sensi...

By: Lu-zhe Sun

Description : Recepteur d’origine nantais (Ron) is overexpressed in a panel of pancreatic cancer cells and tissue samples from pancreatic cancer patients. Ron can be activated by its ligand macrophage stimulating protein (MSP), thereby activating oncogenic signaling pathways. Crosstalk between Ron and EGFR, c-Met, or IGF-1R may provide a mechanism underlying drug resistance. Thus, targeting Ron may represent a novel therapeutic strategy. IMC-RON8 is the first Ron monoclo...

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Plos One : Transcriptomic Response of Porcine Pbmcs to Vaccination...

By: Christian Schönbach

Description : The aim of the present study was to characterize in vivo genome-wide transcriptional responses to immune stimulation in order to get insight into the resulting changes of allocation of resources. Vaccination with tetanus toxoid was used as a model for a mixed Th1 and Th2 immune response in pig. Expression profiles of PBMCs (peripheral blood mononuclear cells) before and at 12 time points over a period of four weeks after initial and booster vaccination at d...

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Plos One : Climate Change Impacts on Streamflow and Subbasin- Scal...

By: Vishal Shah

Description : In the Upper Colorado River Basin (UCRB), the principal source of water in the southwestern U.S., demand exceeds supply in most years, and will likely continue to rise. While General Circulation Models (GCMs) project surface temperature warming by 3.5 to 5.6uC for the area, precipitation projections are variable, with no wetter or drier consensus. We assess the impacts of projected 21st century climatic changes on subbasins in the UCRB using the Soil and Wa...

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Plos One : Heterodimeric Barnase-barstar Vaccine Molecules ; Influ...

By: Lionel G. Filion

Description : It is known that targeting of antigen to antigen presenting cells (APC) increases immune responses. However, it is unclear if more than one APC-specific targeting unit in the antigenic molecule will increase responses. To address this issue, we have here made heterodimeric vaccine molecules that each express four different fusion subunits. The bacterial ribonuclease barnase and its inhibitor barstar interact with high affinity, and the barnase-barstar compl...

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Plos One : High Mannose-binding Antiviral Lectin Pfl from Pseudomo...

By: Roger Chammas

Description : Novel anti-HIV lectin family which shows a strict binding specificity for high mannose glycans has been found in lower organisms. The bacterial orthologue has been identified in the genome of Pseudomonas fluorescens Pf0-1 and the gene coding a putative lectin was cloned, expressed in Escherichia coli and purified by one step gel filtration. Glycan array screening of the recombinant lectin, termed PFL, has revealed that PFL preferentially recognizes high man...

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Plos One : Dynamic Similarity in Titanosaur Sauropods ; Ichnologic...

By: Richard J. Butler

Description : The study of a small sauropod trackway from the Late Cretaceous Fumanya tracksite (southern Pyrenees, Catalonia) and further comparisons with larger trackways from the same locality suggest a causative relationship between gait, gauge, and body proportions of the respective titanosaur trackmakers. This analysis, conducted in the context of scaling predictions and using geometric similarity and dynamic similarity hypotheses, reveals similar Froude numbers an...

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Plos One : Reproducibility of Frankfort Horizontal Plane on 3D Mul...

By: Michael Glogauer

Description : This study revealed excellent intra-examiner reproducibility and inter-examiner reliability of Frankfort Horizontal plane through 3D landmark identification in MRI. Sufficiently stable landmark-based reference plane could be used for different treatments and studies.

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Plos One : High Rates of Tb-iris, Hospital-acquired Infections and...

By: Paula Braitstein

Description : Complications of Antiretroviral Therapy Initiation in Hospitalised Patients with HIV-Associated Tuberculosis

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Plos One : Mother to Mother M2M Peer Support for Women in Preventi...

By: Nicolas Sluis-cremer

Description : M2M programmes offer great potential to empower communities affected by HIV to catalyse positive behaviour change. Our results illustrate how M2M involvement may increase retention in PMTCT programmes. Nondisclosure to one’s partner, as well as some cultural practices prevalent in Zimbabwe appear to be major barriers to participation in M2M programmes.

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Plos One : Could the New Body Shape Index Predict the New Onset of...

By: Claudia Miele

Description : Background : Anthropometric measures could predict the new onset of diabetes mellitus (DM). Recently, a new anthropometric measure (a body shape index, ABSI) was developed, and ABSI could predict premature mortality, even better than WC and BMI. The main aims of the study were to assess the DM predictive power of ABSI based on the follow-up data over 15 years collected from a general Chinese population. Methods and Findings : The data were collected in 1992...

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Plos One : Effect of Heavy Atoms on the Thermal Stability of A-amy...

By: Israel Silman

Description : Currently, there are no versatile and established methods for improving stability of proteins. In an entirely different approach from conventional techniques such as mutagenesis, we attempted to enhance enzyme stability of a-amylase from Aspergillus oryzae using a heavy-atom derivatization technique. We evaluated changes in stability using differential scanning calorimetry (DSC). Candidate heavy atoms were identified using the Heavy-Atom Database System HAT...

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Plos One : Risk Factors of Superimposed Preeclampsia in Women with...

By: Yan Gong

Description : In essential chronic hypertensive women, previous preeclampsia and mean arterial blood pressure of 95 mmHg or higher are associated with increased risks of superimposed preeclampsia.

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Plos One : Elucidating Interactions and Conductivity of Newly Synt...

By: Dennis Salahub

Description : In this paper, we have examined the conductivity and interaction studies of ammonium and imidazolium based ionic liquids (ILs) with the newly synthesised low bandgap polymer (Poly(2-heptadecyl-4-vinylthieno[3,4-d]thiazole) (PHVTT)). Use of low bandgap polymers is the most suitable way to harvest a broader spectrum of solar radiations for solar cells. But, still there is lack of most efficient low bandgap polymer. In order to solve this problem, we have synt...

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Plos One : Tumour Necrosis Factor Alpha, Interferon Gamma and Subs...

By: Bin He

Description : Human scalp skin and hair follicles (HFs) are extra-pituitary sources of prolactin (PRL). However, the intracutaneous regulation of PRL remains poorly understood. Therefore we investigated whether well-recognized regulators of pituitary PRL expression, which also impact on human skin physiology and pathology, regulate expression of PRL and its receptor (PRLR) in situ. This was studied in serum-free organ cultures of microdissected human scalp HFs and skin, ...

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Plos One : Sensory Dysfunction of Bladder Mucosa and Bladder Overs...

By: Michael Bader

Description : Alterations of sensory receptors and enzymes in the bladder mucosa, including over-expression of TRPV1, P2X3, and iNOS proteins, can precipitate the emergence of bladder phasic contractions and oversensitivity through the activation of C-afferents during acidic ATP solution stimulation in FFRs. The down-regulation of eNOS protein in the bladder mucosa of FFRs may lead to a failure to suppress bladder oversensitivity and phasic contractions. Sensory dysfunct...

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