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Plos One : Detailed Dimethylacetal and Fatty Acid Composition of R...

By: Wolf-hagen Schunck

Description : Lipid metabolism in the rumen is responsible for the complex fatty acid profile of rumen outflow compared with the dietary fatty acid composition, contributing to the lipid profile of ruminant products. A method for the detailed dimethylacetal and fatty acid analysis of rumen contents was developed and applied to rumen content collected from lambs fed lucerne or concentrate based diets supplemented with soybean oil. The methodological approach developed con...

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Plos One : Resveratrol Metabolites Modify Adipokine Expression and...

By: Pratibha V. Nerurkar

Description : The present study shows for the first time that resveratrol metabolites have a regulatory effect on adipokine expression and secretion. Since resveratrol has been reported to reduce body-fat accumulation and to improve insulin sensitivity, and considering that these effects are mediated in part by changes in the analyzed adipokines, it may be proposed that resveratrol metabolites play a part in these beneficial effects of resveratrol.

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Plos One : Do Global Diversity Patterns of Vertebrates Reflect Tho...

By: Diego Fontaneto

Description : Few studies of global diversity gradients in plants exist, largely because the data are not available for all species involved. Instead, most global studies have focussed on vertebrates, as these taxa have historically been associated with the most complete data. Here, we address this shortfall by first investigating global diversity gradients in monocots, a morphologically and functionally diverse clade representing a quarter of flowering plant diversity, ...

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Plos One : Müller Cell Reactivity in Response to Photoreceptor Deg...

By: Ram Nagaraj

Description : Background : Retinal degeneration in transgenic rats that express a mutant cilia gene polycystin-2 (CMV-PKD2(1/703)HA) is characterized by initial photoreceptor degeneration and glial activation, followed by vasoregression and neuronal degeneration (Feng et al., 2009, PLoS One 4 : e7328). It is unknown whether glial activation contributes to neurovascular degeneration after photoreceptor degeneration. We characterized the reactivity of Mu¨ ller glial cells ...

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Plos One : Why Herd Size Matters – Mitigating the Effects of Lives...

By: Jon Moen

Description : Analysing the effect of pastoral risk management strategies provides insights into a system of subsistence that have persevered in marginal areas for hundreds to thousands of years and may shed light into the future of around 200 million households in the face of climate change. This study investigated the efficiency of herd accumulation as a buffer strategy by analysing changes in livestock holdings during an environmental crisis in the Saami reindeer husb...

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Plos One : Oral Microbiome of Deep and Shallow Dental Pockets in C...

By: Robert A. Burne

Description : We examined the subgingival bacterial biodiversity in untreated chronic periodontitis patients by sequencing 16S rRNA genes. The primary purpose of the study was to compare the oral microbiome in deep (diseased) and shallow (healthy) sites. A secondary purpose was to evaluate the influences of smoking, race and dental caries on this relationship. A total of 88 subjects from two clinics were recruited. Paired subgingival plaque samples were taken from each s...

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Plos One : Impact of Implementing Evidence-based Acute Stroke Inte...

By: Antony Bayer

Description : There was evidence of better one year survival in patients receiving specific acute interventions after stroke with a significantly greater effect in stroke subgroups, suggesting the possibility of re-organising stroke services to ensure that the most appropriate care is made accessible to patients likely to derive the most benefits from such interventions

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Plos One : Low Bone Strength is a Manifestation of Phenylketonuria...

By: Marlon R. Schneider

Description : Skeletal fragility, as reflected in brittle and weak femora, is an inherent feature of PKU. This PKU bone phenotype is attenuated by a GMP diet compared with an AA diet.

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Plos One : Long Qt Interval in Turner Syndrome – a High Prevalence...

By: Katriina Aalto-setala

Description : There is a high prevalence of mutations in the major LQTS genes in women with TS and prolonged QTc. It remains to be settled, whether these findings are related to the unexplained excess mortality in Turner women.

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Plos One : Effect of Fruit Juice on Cholesterol and Blood Pressure...

By: Qamaruddin Nizami

Description : This meta-analysis suggested that fruit juice had a borderline significant effect on reducing DBP, but had no effect on TC, HDL-C, LDL-C concentrations or SBP

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Plos One : Gene Expression Patterns of Hemizygous and Heterozygous...

By: Swati Palit Deb

Description : Patterns of mRNA and miRNA expression in cells and tumours depend on heterozygous/hemizygous status of KIT mutations, and deletion/presence of TYR568 & TYR570 residues. Thus each mutation of KIT may drive specific oncogenic pathways.

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Plos One : Only Missense Mutations Affecting the Dna Binding Domai...

By: Todd W. Miller

Description : The presence of a TP53 gene mutation can influence tumour response to some treatments, especially in breast cancer. In this study, we analysed p53 mRNA expression, LOH at 17p13 and TP53 mutations from exons 2 to 11 in 206 patients with breast carcinoma and correlated the results with disease-free and overall survival. The observed mutations were classified according to their type and location in the three protein domains (transactivation domain, DNA binding...

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Plos One : Resting-state Functional Connectivity Patterns Predict ...

By: Olaf Sporns

Description : Resting-state functional connectivity (RSFC) offers a novel approach to reveal the temporal synchronization of functionally related brain regions. Recent studies have identified several RSFCs whose strength was associated with reading competence in alphabetic languages. In the present study, we examined the role of intrinsic functional relations for reading a nonalphabetic language – Chinese – by correlating RSFC maps of nine Chinese reading-related seed re...

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Plos One : Scaling up Antiretroviral Treatment Services in Karnata...

By: Madhukar Pai

Description : We found an increasing trend of median CD4 counts among PLHIV presenting to ART centres in Karnataka, an indicator of enhanced and early access to HIV care. Equal proportion of females and higher baseline CD4 counts among them allays any fear of differential access by gender. Despite this relative success, a substantial proportion still presented at low CD4 cell counts indicating possibly delayed HIV diagnosis and delayed linkage to HIV care. Universal HIV ...

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Plos One : Drug Cocktail Optimization in Chemotherapy of Cancer, V...

By: Daotai Nie

Description : We present a comprehensive analysis of over 100 common cancer treatment regimens regarding drug-drug interactions and present alternatives avoiding CYP overload. Typical concomitant medication, e.g. antiemetics or antibiotics is a preferred subject to improvement. A webtool, which allows drug cocktail optimization was developed and is publicly available on http:/bioinformatics.charite.de/chemotherapy.

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Plos One : a Kinome Screen Identifies Checkpoint Kinase 1 Chk1 as ...

By: Wael El-rifai

Description : Gemcitabine is among the most efficacious and widely used antimetabolite agents. Its molecular targets are ribonucleotide reductase M1 (RRM1) and elongating DNA. Acquired and de novo resistance as a result of RRM1 overexpression are major obstacles to therapeutic efficacy. We deployed a synthetic lethality screen to investigate if knockdown of 87 selected protein kinases by siRNA could overcome RRM1-dependent gemcitabine resistance in high and low RRM1-expr...

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Plos One : Bird Communities of the Arctic Shrub Tundra of Yamal ; ...

By: Katherine Renton

Description : If current arctic changes result in a shrubification of the landscape as many studies suggested, we would expect an increase in the overall bird abundance together with an increase of local specialists, since they are associated with willow thickets. The majority of these species have a southern origin and their increase in abundance would represent a strengthening of the boreal component in the southern tundra, perhaps at the expense of species typical of ...

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Plos One : Acidithiobacillus Caldus Sulfur Oxidation Model Based o...

By: Nikolai Lebedev

Description : Background : Acidithiobacillus caldus (A. caldus) is widely used in bio-leaching. It gains energy and electrons from oxidation of elemental sulfur and reduced inorganic sulfur compounds (RISCs) for carbon dioxide fixation and growth. Genomic analyses suggest that its sulfur oxidation system involves a truncated sulfur oxidation (Sox) system (omitting SoxCD), non- Sox sulfur oxidation system similar to the sulfur oxidation in A. ferrooxidans, and sulfur oxyg...

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Plos One : Fine Mapping of Wheat Stripe Rust Resistance Gene Yr26 ...

By: James C. Nelson

Description : The Yr26 gene, conferring resistance to all currently important races of Puccinia striiformis f. sp. tritici (Pst) in China, was previously mapped to wheat chromosome deletion bin C-1BL-6-0.32 with low-density markers. In this study, collinearity of wheat to Brachypodium distachyon and rice was used to develop markers to saturate the chromosomal region containing the Yr26 locus, and a total of 2,341 F2 plants and 551 F2:3 progenies derived from Avocet S692R...

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Plos One : Arginase Treatment Prevents the Recovery of Canine Lymp...

By: Kristy L. Richards

Description : Rapidly growing tumor cells require a nutrient-rich environment in order to thrive, therefore, restricting access to certain key amino acids, such as arginine, often results in the death of malignant cells, which frequently display defective cell cycle check-point control. Healthy cells, by contrast, become quiescent and remain viable under arginine restriction, displaying full recovery upon return to arginine-rich conditions. The use of arginase therapy to...

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