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Plos One : Molecular Dynamics Reveal Binding Mode of Glutathionyls...

By: Dan Zilberstein

Description : The trypanothione synthetase (TryS) catalyses the two-step biosynthesis of trypanothione from spermidine and glutathione and is an attractive new drug target for the development of trypanocidal and antileishmanial drugs, especially since the structural information of TryS from Leishmania major has become available. Unfortunately, the TryS structure was solved without any of the substrates and lacks loop regions that are mechanistically important. This contr...

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Plos One : Immunization of Aged Pigs with Attenuated Pseudorabies ...

By: Gourapura J. Renukaradhya

Description : Our results demonstrate a utility for CpG ODN, as a safe vaccine adjuvant for promoting effective systemic immune responses in aged pig model. This agent could have important clinical uses in overcoming some of age-associated depressions in immune function that occur in response to vaccination.

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Plos One : Life on Human Surfaces ; Skin Metagenomics, Volume 8

By: Stefan Bereswill

Description : The human skin microbiome could provide another example, after the gut, of the strong positive or negative impact that human colonizing bacteria can have on health. Deciphering functional diversity and dynamics within human skin microbial communities is critical for understanding their involvement and for developing the appropriate substances for improving or correcting their action. We present a direct PCR-free high throughput sequencing approach to unrave...

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Plos One : Ldx ; Estimation of Linkage Disequilibrium from High- T...

By: Rongling Wu

Description : High-throughput pooled resequencing offers significant potential for whole genome population sequencing. However, its main drawback is the loss of haplotype information. In order to regain some of this information, we present LDx, a computational tool for estimating linkage disequilibrium (LD) from pooled resequencing data. LDx uses an approximate maximum likelihood approach to estimate LD (r2) between pairs of SNPs that can be observed within and among sin...

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Plos One : Oxytocin Enhances Social Persuasion During Hypnosis, Vo...

By: Tiziana Zalla

Description : It has long been argued that hypnosis cannot promote behaviors that people will not otherwise engage in. Oxytocin can enhance trust in others, and may promote the extent to which a hypnotized person complies with the suggestion of a hypnotist. This double-blind placebo study administered oxytocin or placebo to high hypnotizable participants (N = 28), who were then administered hypnotic suggestions for socially unorthodox behaviors, including swearing during...

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Plos One : Association Between Circulating Levels of Igf-1 and Igf...

By: Xianglin Shi

Description : Inverse association was shown between IGFBP-3 and lung cancer in the case-control studies,and the circulating level of IGFBP-3 underwent a decline during tumorogenesis and development of lung cancer, which suggested IGFBP-3 a promising candidate for the biomarker of lung cancer.

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Plos One : Identification and Candidate Gene Analysis of a Novel P...

By: Zhengguang Zhang

Description : Resistance to Phytophthora sojae isolate PsMC1 was evaluated in 102 F2:3 families derived from a cross between the resistant soybean cultivar Wandou 15 and the susceptible cultivar Williams and genotyped using simple sequence repeat (SSR) markers. The segregation ratio of resistant, segregating, and susceptible phenotypes in the population suggested that the resistance in Wandou 15 was dominant and monogenic. Twenty-six polymorphic SSR markers were identifi...

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Plos One : Genetic Interactions Between Neurofibromin and Endothel...

By: L. Debra Silver

Description : When mutations in two different genes produce the same mutant phenotype, it suggests that the encoded proteins either interact with each other, or act in parallel to fulfill a similar purpose. Haploinsufficiency of Neurofibromin and overexpression of Endothelin 3 both cause increased numbers of melanocytes to populate the dermis during mouse development, and thus we are interested in how these two signaling pathways might intersect. Neurofibromin is mutated...

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Plos One : Study of Global Transcriptional Changes of N-glcnac2 Pr...

By: Peiwen Fei

Description : Increased levels of N-linked (b-N- acetylglucosamine)2 [N-GlcNAc2]-modified proteins have been recognized to be an effective response to glucose deprivation. In the first step of this study, using a next generation sequencer, we investigated the global transcriptional changes induced by glucose deprivation in a T24 bladder carcinoma cell line, producing NGlcNAc2- modified proteins under glucose deprivation. Our transcriptome analysis revealed significant up...

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Plos One : Expression and Significance of Neuroligins in Myenteric...

By: Anthony W.I. Lo

Description : Neuroligins were expressed in ICC-MY of human beings, and the expression varies from different segments of HSCR. This abnormal expression might play an important role in the pathogenesis of this disease through affecting the synaptic function of ICC-MY.

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Plos One : Multi-gene Analysis Reveals a Lack of Genetic Divergenc...

By: Joao Pinto

Description : The discrimination and taxonomic identification of marine species continues to pose a challenge despite the growing number of diagnostic metrics and approaches. This study examined the genetic relationship between two sibling species of the genus Calanus (Crustacea: Copepoda: Calanidae), C. agulhensis and C. sinicus, using a multi-gene analysis. DNA sequences were determined for portions of the mitochondrial cytochrome c oxidase I (mtCOI): nuclear citrate s...

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Plos One : Inter-specific Competition, but Not Different Soil Micr...

By: James F. Cahill

Description : Evidence that plants differ in their ability to take up both organic (ON) and inorganic (IN) forms of nitrogen (N) has increased ecologists’ interest on resource-based plant competition. However, whether plant uptake of IN and ON responds to differences in soil microbial community composition and/or functioning has not yet been explored, despite soil microbes playing a key role in N cycling. Here, we report results from a competition experiment testing the ...

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Plos One : Genomic Profiling of Oral Squamous Cell Carcinoma by Ar...

By: Jörg D. Hoheisel

Description : We designed a study to investigate genetic relationships between primary tumors of oral squamous cell carcinoma (OSCC) and their lymph node metastases, and to identify genomic copy number aberrations (CNAs) related to lymph node metastasis. For this purpose, we collected a total of 42 tumor samples from 25 patients and analyzed their genomic profiles by array-based comparative genomic hybridization. We then compared the genetic profiles of metastatic primar...

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Plos One : Aerobic Interval Training Partly Reverse Contractile Dy...

By: Leon J. De Windt

Description : Post infarction HF in rats causes profound impairment in atrial myocyte contractile function and Ca2+ handling. The observed dysfunction in atrial myocytes was partly reversed after aerobic interval training.

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Plos One : Pentamers Not Found in the Universal Proteome Can Enhan...

By: Ernesto T. Marques

Description : Certain short peptides do not occur in humans and are rare or non-existent in the universal proteome. Antigens that contain rare amino acid sequences are in general highly immunogenic and may activate different arms of the immune system. We first generated a list of rare, semi-common, and common 5-mer peptides using bioinformatics tools to analyze the UniProtKB database. Experimental observations indicated that rare and semi-common 5-mers generated stronger...

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Plos One : Minimal Intensity Physical Activity Standing and Walkin...

By: Stephane Blanc

Description : One hour of daily physical exercise cannot compensate the negative effects of inactivity on insulin level and plasma lipids if the rest of the day is spent sitting. Reducing inactivity by increasing the time spent walking/standing is more effective than one hour of physical exercise, when energy expenditure is kept constant.

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Plos One : Betulinic Acid Selectively Increases Protein Degradatio...

By: Paul J. Galardy

Description : Inhibition of the ubiquitin-proteasome system (UPS) of protein degradation is a valid anti-cancer strategy and has led to the approval of bortezomib for the treatment of multiple myeloma. However, the alternative approach of enhancing the degradation of oncoproteins that are frequently overexpressed in cancers is less developed. Betulinic acid (BA) is a plantderived small molecule that can increase apoptosis specifically in cancer but not in normal cells, m...

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Plos One : Life Expectancy and Death by Diseases of the Circulator...

By: Marianna Mazza

Description : Our data show that persons in the Nordic countries with schizophrenia or bipolar disorder have a substantially reduced life expectancy. An evaluation of the reasons for these increased mortality rates should be prioritized when planning healthcare in the coming years.

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Plos One : Candidate Gene Approach Identifies Multiple Genes and S...

By: David S. Milstone

Description : Loss of Tbx4 results in absence of chorio-allantoic fusion and failure of formation of the primary vascular plexus of the allantois leading to embryonic death at E10.5. We reviewed the literature for genes implicated in chorio-allantoic fusion, cavitation and vascular plexus formation, processes affected in Tbx4 mutant allantoises. Using this candidate gene approach, we identified a number of genes downstream of Tbx4 in the allantois including extracellular...

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Plos One : Xanthurenic Acid Binds to Neuronal G-protein-coupled Re...

By: Gilles J. Guillemin

Description : Xanthurenic acid (XA) is a metabolite of the tryptophan oxidation pathway through kynurenine and 3-hydroxykynurenine. XA was until now considered as a detoxification compound and dead-end product reducing accumulation of reactive radical species. Apart from a specific role for XA in the signaling cascade resulting in gamete maturation in mosquitoes, nothing was known about its functions in other species including mammals. Based upon XA distribution, transpo...

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