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Plos One : Pesticide Acute Toxicity is a Better Correlate of U.S. ...

By: Rohan H. Clarke

Description : Common agricultural birds are in decline, both in Europe and in North America. Evidence from Europe suggests that agricultural intensification and, for some species, the indirect effects of pesticides mediated through a loss of insect food resource is in part responsible. On a state-by-state basis for the conterminous Unites States (U.S.), we looked at several agronomic variables to predict the number of grassland species increasing or declining according t...

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Plos One : Analysis of Candidate Colitis Genes in the Gdac1 Locus ...

By: Stefan Bereswill

Description : Among the remaining 10 genes, we identified Pla2g4f and Duox2 as the most likely colitis gene candidates, because GPX metabolizes PLA2G4F and DUOX2 products. Pla2g4f is a phospholipase A2 that has three potentially significant nsSNP variants and showed expression differences across mouse strains. PLA2G4F produces arachidonic acid, which is a substrate for lipoxygenases and, in turn, for GPXs. DUOX2 produces H2O2 and may control microbial populations. DUOX-1...

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Plos One : Influence of Structural Symmetry on Protein Dynamics, V...

By: Franca Fraternali

Description : Structural symmetry in homooligomeric proteins has intrigued many researchers over the past several decades. However, the implication of protein symmetry is still not well understood. In this study, we performed molecular dynamics (MD) simulations of two forms of trp RNA binding attenuation protein (TRAP), the wild-type 11-mer and an engineered 12-mer, having two different levels of circular symmetry. The results of the simulations showed that the inter-sub...

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Plos One : Patterns of Spontaneous Brain Activity in Amyotrophic L...

By: James A. Duce

Description : By detecting spontaneous low-frequency fluctuations (LFF) of blood oxygen level–dependent (BOLD) signals, resting-state functional magnetic resonance imaging (rfMRI) measurements are believed to reflect spontaneous cerebral neural activity. Previous fMRI studies were focused on the examination of motor-related areas and little is known about the functional changes in the extra-motor areas in amyotrophic lateral sclerosis (ALS) patients. The aim of this stud...

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Plos One : Association of Chronic Kidney Disease and Peripheral Ar...

By: Angelo Scuteri

Description : Inappropriate left ventricular mass index (LVM) may develop as a response to particular hemodynamic and metabolic alterations. Inappropriate LVM and peripheral artery disease (PAD) characterized by abnormally low or high ankle-brachial index (ABI) are common in chronic kidney disease (CKD) patients, in whom there may be a close and cause-effect relationship. The aim of this study is to assess whether CKD and abnormal ABI has an independent and additive asso...

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Plos One : Serum Her 2 Extracellular Domain Level is Correlated wi...

By: Syed A. Aziz

Description : The high specificity of the serum HER 2 ECD assay in predicting tissue HER 2 status suggests its potential as a surrogate marker of the HER 2 status in gastric cancer.

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Plos One : Dietary Monounsaturated Fatty Acids Intake and Risk of ...

By: H. Peter Soyer

Description : These findings support the beneficial effect of dietary olive oil or healthy diet habits associated with olive oil consumption on the severity of facial photoaging.

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Plos One : Development of a Novel Dna Aptamer Ligand Targeting to ...

By: Aamir Ahmad

Description : The present study used a spontaneous cell-based SELEX method (Systemic Evolution of Ligands by EXponential Enrichment) to produce DNA aptamers that specifically bind to cell surface proteins or biomarkers produced by primary cultured mouse tumor endothelial cells (mTECs). In solid tumors, new blood vessels are formed through an angiogenesis process, and this plays a critical role in cancer development as well as metastasis. To combat angiogenesis, an approp...

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Plos One : Tracking Single Cells in Live Animals Using a Photoconv...

By: Marc Tjwa

Description : We describe a novel photoconversion technique to track individual cells in vivo using a commercial lipophilic membrane dye, DiR. We show that DiR exhibits a permanent fluorescence emission shift (photoconversion) after light exposure and does not reacquire the original color over time. Ratiometric imaging can be used to distinguish photoconverted from nonconverted cells with high sensitivity. Combining the use of this photoconvertible dye with intravital mi...

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Plos One : the Microrna -23B, Volume 7

By: Moray Campbell

Description : MicroRNAs (miRs) are small, endogenous, non-coding RNAs that regulate the stability and/or translation of complementary mRNA targets. MiRs have emerged not only as critical modulators of normal physiologic processes, but their deregulation may significantly impact prostate and other cancers. The expression of miR-23b and miR-27b, which are encoded by the same miR cluster (miR-23b/-27b), are downregulated in metastatic, castration-resistant tumors compared t...

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Plos One : Cascading Effects of Ocean Acidification in a Rocky Sub...

By: Tasman Crowe

Description : Temperate marine rocky habitats may be alternatively characterized by well vegetated macroalgal assemblages or barren grounds, as a consequence of direct and indirect human impacts (e.g. overfishing) and grazing pressure by herbivorous organisms. In future scenarios of ocean acidification, calcifying organisms are expected to be less competitive : among these two key elements of the rocky subtidal food web, coralline algae and sea urchins. In order to highl...

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Plos One : Comparative Study of Human and Mouse Postsynaptic Prote...

By: Anna Dunaevsky

Description : Direct comparison of protein components from human and mouse excitatory synapses is important for determining the suitability of mice as models of human brain disease and to understand the evolution of the mammalian brain. The postsynaptic density is a highly complex set of proteins organized into molecular networks that play a central role in behavior and disease. We report the first direct comparison of the proteome of triplicate isolates of mouse and hum...

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Plos One : Morphology and Nanomechanics of Sensory Neurons Growth ...

By: Igor Sokolov

Description : prior peripheral nerve injury in vivo, promotes a rapid elongated mode of sensory neurons neurite regrowth in vitro. This in vitro model of conditioned axotomy allows analysis of the cellular and molecular mechanisms leading to an improved neurite re-growth. Our differential interference contrast microscopy and immunocytochemistry results show that conditioned axotomy, induced by sciatic nerve injury, did not increase somatic size of adult lumbar sensory ne...

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Plos One : Mecp2 Dependent Heterochromatin Reorganization During N...

By: Pierre-antoine Defossez

Description : The X-linked Mecp2 is a known interpreter of epigenetic information and mutated in Rett syndrome, a complex neurological disease. MeCP2 recruits HDAC complexes to chromatin thereby modulating gene expression and, importantly regulates higher order heterochromatin structure. To address the effects of MeCP2 deficiency on heterochromatin organization during neural differentiation, we developed a versatile model for stem cell in vitro differentiation. Therefore...

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Plos One : an Integrated Tool to Study Mhc Region ; Accurate Snv D...

By: Xi (Erick) Lin

Description : The major histocompatibility complex (MHC) is one of the most variable and gene-dense regions of the human genome. Most studies of the MHC, and associated regions, focus on minor variants and HLA typing, many of which have been demonstrated to be associated with human disease susceptibility and metabolic pathways. However, the detection of variants in the MHC region, and diagnostic HLA typing, still lacks a coherent, standardized, cost effective and high co...

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Plos One : 11Β-hydroxysteroid Dehydrogenase Type 1 Gene Knockout A...

By: Kang Sun

Description : These findings suggest that 11bHSD1 inhibition may have the potential to limit plaque development at the vessel wall and regulate foam cell formation independent of changes in plasma lipids. The diminished cytokine response to oxidized LDL stimulation is consistent with the reduction in TLR expression and suggests involvement of 11bHSD1 in modulating binding of pro-atherogenic TLR ligands.

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Plos One : Comparison of Arterial Spin Labeling and Dynamic Suscep...

By: Yong Fan

Description : Quantitative measurement of ASL perfusion is well correlated with DSC perfusion. However, ASL perfusion may overestimate the perfusion defects and therefore further refinement of the true penumbra threshold and improved ASL technique are necessary before applying ASL in therapeutic trials.

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Plos One : Longitudinal Investigation of Public Trust in Instituti...

By: Joseph T. Wu

Description : Results show clear patterns of skepticism and mistrust on the part of the public relative to various institutions and their actions. Results underscore the importance of systematically investigating trust of the public relative to epidemics. Moreover, studies investigating the evolution of the public’s memories of the pandemic over the coming years may be important to understand reactions to future pandemics. A systematic research program on trust can infor...

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Plos One : the Cassava Mealybug Phenacoccus Manihoti in Asia ; Fir...

By: Peter Shaw

Description : Phenacoccus manihoti Matile-Ferrero (Hemiptera : Pseudococcidae), one of the most serious pests of cassava worldwide, has recently reached Asia, raising significant concern over its potential spread throughout the region. To support management decisions, this article reports recent distribution records, and estimates the climatic suitability for its regional spread using a CLIMEX distribution model. The article also presents a taxonomic key that separates P...

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Plos One : Combination of Taxanes, Cisplatin and Fluorouracil as I...

By: Jose Luis Perez-gracia

Description : The TPF induction chemotherapy regimen leads to a significant survival advantage with acceptable toxicity rates for patients with locally advanced head and neck cancer compared with the PF regimen.

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