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Plos One : Unlocking the Genetic Diversity of Maize Landraces with...

By: Randall P. Niedz

Description : Landraces are valuable genetic resources for broadening the genetic base of elite germplasm in maize. Extensive exploitation of landraces has been hampered by their genetic heterogeneity and heavy genetic load. These limitations may be overcome by the in-vivo doubled haploid (DH) technique. A set of 132 DH lines derived from three European landraces and 106 elite flint (EF) lines were genotyped for 56,110 single nucleotide polymorphism (SNP) markers and eva...

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Plos One : the Sensitivity of Diffuse Large B-cell Lymphoma Cell L...

By: Daniel T. Starczynowski

Description : These studies indicate that the sensitivity of DLBCL to treatment with HDACi’s is dependent on the complex regulation of BCL-2 family members and that BCL-2 antagonists may enhance the response of a subset of DLBCL patients to HDACi treatment

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Plos One : Interferon Gamma Release Assays for the Diagnosis of La...

By: Delia Goletti

Description : In low TB prevalence settings, the QFT-IT yields more positive and fewer indeterminate results than T-SPOT.TB. Negative results on the QFT-IT and indeterminate/unavailable results on the T-SPOT.TB were more common in individuals with low CD4+ T-cell counts.

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Plos One : a Novel Statistical Prognostic Score Model That Include...

By: Goli Samimi

Description : sCXCL5 level was determined to be an independent prognostic factor for NPC patients. The novel statistical CC model, which includes sCXCL5 levels and clinical classification, could be helpful in predicting the prognosis of NPC patients.

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Plos One : Semen Levels of Spermatid-specific Thioredoxin-3 Correl...

By: Joel R. Drevet

Description : Spermatid specific thioredoxin-3 (SPTRX3 or TXNDC8) is a testis/male germ line specific member of thioredoxin family that accumulates in the superfluous cytoplasm of defective human spermatozoa. We hypothesized that semen levels of SPTRX3 are reflective of treatment outcome in assisted reproductive therapy (ART) couples treated by in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI). Relationship between SPTRX3 and treatment outcome was i...

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Plos One : Confidence in Emotion Perception in Point-light Display...

By: Nicole Wenderoth

Description : One central issue in social cognitive neuroscience is that perceiving emotions in others relates to activating the same emotion in oneself. In this study we sought to examine how the ability to perceive own emotions assessed with the Toronto Alexithymia Scale related to both the ability to perceive emotions depicted in point-light displays and the confidence in these perceptions. Participants observed video scenes of human interactions, rated the depicted v...

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Plos One : Heme Binding Proteins of Bartonella Henselae Are Requir...

By: Stefan Bereswill

Description : Bartonella are hemotropic bacteria responsible for emerging zoonoses. These heme auxotroph alphaproteobacteria must import heme for their growth, since they cannot synthesize it. To import exogenous heme, Bartonella genomes encode for a complete heme uptake system enabling transportation of this compound into the cytoplasm and degrading it to release iron. In addition, these bacteria encode for four or five outer membrane heme binding proteins (Hbps). The s...

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Plos One : Lower Healthcare Costs Associated with the Use of a Sin...

By: Maarten Postma

Description : The single pill regimen is as effective as the two- and three-pill regimens of the same drugs, but if started as first-line induction therapy there would be a 20% savings on healthcare costs at six and 17% of costs at twelve months compared with TruvadaH+EFV, that generated the next lowest costs.

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Plos One : Association of the Ephreceptor Tyrosinekinase-type A2 E...

By: Balraj Mittal

Description : Polymorphism, rs3754334, might be a variant on the EPHA2 gene that is commonly associated with the risk for age-related cataract in different ethnical and geographical populations.

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Plos One : the Structure of Spatial Networks and Communities in Bi...

By: Jesus Gomez-gardenes

Description : Bicycle sharing systems exist in hundreds of cities around the world, with the aim of providing a form of public transport with the associated health and environmental benefits of cycling without the burden of private ownership and maintenance. Five cities have provided research data on the journeys (start and end time and location) taking place in their bicycle sharing system. In this paper, we employ visualization, descriptive statistics and spatial and n...

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Plos One : Multiple Cationic Amphiphiles Induce a Niemann-pick C P...

By: Lijun Rong

Description : Ebola virus (EBOV) is an enveloped RNA virus that causes hemorrhagic fever in humans and non-human primates. Infection requires internalization from the cell surface and trafficking to a late endocytic compartment, where viral fusion occurs, providing a conduit for the viral genome to enter the cytoplasm and initiate replication. In a concurrent study, we identified clomiphene as a potent inhibitor of EBOV entry. Here, we screened eleven inhibitors that tar...

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Plos One : Low Concentrations of Silver Nanoparticles in Biosolids...

By: Stephen J. Johnson

Description : A large fraction of engineered nanomaterials in consumer and commercial products will reach natural ecosystems. To date, research on the biological impacts of environmental nanomaterial exposures has largely focused on high-concentration exposures in mechanistic lab studies with single strains of model organisms. These results are difficult to extrapolate to ecosystems, where exposures will likely be at low-concentrations and which are inhabited by a divers...

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Plos One : Proprioception is Robust Under External Forces, Volume 8

By: Nicholas P Holmes

Description : Information from cutaneous, muscle and joint receptors is combined with efferent information to create a reliable percept of the configuration of our body (proprioception). We exposed the hand to several horizontal force fields to examine whether external forces influence this percept. In an end-point task subjects reached visually presented positions with their unseen hand. In a vector reproduction task, subjects had to judge a distance and direction visua...

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Plos One : Increased Cell Proliferation and Mucocyte Density in th...

By: Patrick Prunet

Description : Recovery of coral after bleaching episodes is a critical period for the health of the reef ecosystem. While events such as symbiont (genus Symbiodinium) shifting/shuffling or tissue apoptosis have been demonstrated to occur following bleaching, little is known concerning tissue recovery or cell proliferation. Here, we studied the sea anemone Aiptasia pallida exposed to a transient elevation of water temperature combined with high illumination (33uC and 1900...

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Plos One : Emergent Dynamics from Spiking Neuron Networks Through ...

By: Matjaz Perc

Description : Low-dimensional attractive manifolds with flows prescribing the evolution of state variables are commonly used to capture the lawful behavior of behavioral and cognitive variables. Neural network dynamics underlie many of the mechanistic explanations of function and demonstrate the existence of such low-dimensional attractive manifolds. In this study, we focus on exploring the network mechanisms due to asymmetric couplings giving rise to the emergence of ar...

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Plos One : Serine Protease Htra1 Antagonizes Transforming Growth F...

By: Luc Malaval

Description : HTRA1 is a member of the High Temperature Requirement (HTRA1) family of serine proteases, which play a role in several biological and pathological processes. In part, HTRA1 regulation occurs by inhibiting the TGF-b signaling pathway, however the mechanism of inhibition has not been fully defined. Previous studies have shown that HTRA1 is expressed in a variety of tissues, including sites of skeletal development. HTRA1 has also been implicated in the process...

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Plos One : Association Between Chads2 Score and the Preventive Eff...

By: Adrian V Hernandez

Description : The CHADS2 score is a convenient scoring system for predicting the incidence of new-onset AF and may help in identifying the patients who will benefit most from statin use for the prevention of arrhythmia after AMI.

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Plos One : Comparative Genomics Identifies the Mouse Bmp3 Promoter...

By: Bernd Sokolowski

Description : The Bone Morphogenetic Protein (BMP) pathway is a multi-member signaling cascade whose basic components are found in all animals. One member, BMP3, which arose more recently in evolution and is found only in deuterostomes, serves a unique role as an antagonist to both the canonical BMP and Activin pathways. However, the mechanisms that control BMP3 expression, and the cis-regulatory regions mediating this regulation, remain poorly defined. With this in mind...

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Plos One : Exploring Agricultural Livelihood Transitions with an A...

By: Bin Jiang

Description : Rural populations are undergoing rapid changes in both their livelihoods and land uses, with associated impacts on ecosystems, global biogeochemistry, and climate change. A primary challenge is, thus, to explain these shifts in terms of the actors and processes operating within a variety of land systems in order to understand how land users might respond locally to future changes in broader-scale environmental and economic conditions. Using ‘induced intensi...

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Plos One : Anatomical Correlates of Cognitive Functions in Early P...

By: Bogdan Draganski

Description : Our results confirm the presence of changes in grey matter thickness at relatively early PD stage and support previous studies showing thinning and atrophy in the neocortex and subcortical regions. Relative cortical thickening in PDMCI may instead express compensatory neuroplasticity. Brain reserve mechanisms might first modulate cognitive decline during the initial stages of PD.

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