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Plos One : Impact of Illness and Medical Expenditure on Household ...

By: Harry Zhang

Description : Early studies conducted in other Asian countries and rural China found negative associations between illness conditions and medical expenditure with other types of consumptions. This study was conducted in three major cities and surrounding areas in western China, which had not been well investigated in published literature. The observed consumption patterns were different from those in early studies, and the negative associations were not observed. This st...

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Plos One : Geochemical and Visual Indicators of Hydrothermal Fluid...

By: Caroline P. Slomp

Description : In the austral summer of 2011 we undertook an investigation of three volcanic highs in the Central Bransfield Basin, Antarctica, in search of hydrothermal activity and associated fauna to assess changes since previous surveys and to evaluate the extent of hydrothermalism in this basin. At Hook Ridge, a submarine volcanic edifice at the eastern end of the basin, anomalies in water column redox potential (Eh) were detected close to the seafloor, unaccompanied...

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Plos One : External Validation of a Nomogram That Predicts the Pat...

By: Alfredo Fusco

Description : Nixon’s nomogram is a valuable predictive model for the Chinese population and has been externally validated. It has good performance for patients with a high risk of malignancy and may be more suitable for use with these patients in China.

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Plos One : Prophylactic Effect of Probiotics on the Development of...

By: Michael Platten

Description : Probiotics are live bacteria that confer health benefits to the host physiology. Although protective role of probiotics have been reported in diverse diseases, no information is available whether probiotics can modulate neuromuscular immune disorders. We have recently demonstrated that IRT5 probiotics, a mixture of 5 probiotics, could suppress diverse experimental disorders in mice model. In this study we further investigated whether IRT5 probiotics could m...

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Plos One : Helicobacter Pyloricolonization Ameliorates Glucose Hom...

By: Ivo G. Boneca

Description : Gastric infection with some commensal strains of H. pylori ameliorates glucose homeostasis in mice through a PPAR c-dependent mechanism and modulates macrophage and Treg cell infiltration into the abdominal white adipose tissue.

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Plos One : Biologically-directed Modeling Reflects Cytolytic Clear...

By: Cristian Apetrei

Description : The disappointing outcomes of cellular immune-based vaccines against HIV-1 despite strong evidence for the protective role of CD8+ T lymphocytes (CTLs) has prompted revisiting the mechanisms of cellular immunity. Prior data from experiments examining the kinetics of Simian Immunodeficiency Virus (SIV) clearance in infected macaques with or without in vivo CD8 depletion were interpreted as refuting the concept that CTLs suppress SIV/HIV by direct killing of ...

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Plos One : Why Don’t Men Understand Women Altered Neural Networks ...

By: Frank Krueger

Description : Men are traditionally thought to have more problems in understanding women compared to understanding other men, though evidence supporting this assumption remains sparse. Recently, it has been shown, however, that mens problems in recognizing women’s emotions could be linked to difficulties in extracting the relevant information from the eye region, which remain one of the richest sources of social information for the attribution of mental states to others....

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Plos One : the Fear Protein Slk19 Restricts Cdc14 Phosphatase to t...

By: Anja-katrin Bielinsky

Description : In Saccharomyces cerevisiae mitosis, the protein Slk19 plays an important role in the initial release of Cdc14 phosphatase from the nucleolus to the nucleus in early anaphase, an event that is critical for proper anaphase progression. A role for Slk19 in later mitotic stages of Cdc14 regulation, however, has not been demonstrated. While investigating the role of Slk19 post-translational modification on Cdc14 regulation, we found that a triple point mutant o...

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Plos One : Kindlin 2 Regulates Myogenic Related Factor Myogenin Vi...

By: Zhongjun Zhou

Description : Kindlin 2, as an integrin-associated protein, is required for myocyte elongation and fusion. However, the association of Kindlin 2 with muscle differentiation-related signaling pathways is unknown. Here, we identified a mechanism that Kindlin 2 regulates myogenic regulatory factors myogenin via a canonical Wnt/b-catenin signaling. We found that knockdown of Kindlin 2 leads to the abolishment of b-catenin/TCF4-mediated transcription in C2C12 cells, followed ...

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Plos One : Identification of a Novel Bat Papillomavirus by Metagen...

By: Todd Davis

Description : The discovery of novel viruses in animals expands our knowledge of viral diversity and potentially emerging zoonoses. Highthroughput sequencing (HTS) technology gives millions or even billions of sequence reads per run, allowing a comprehensive survey of the genetic content within a sample without prior nucleic acid amplification. In this study, we screened 156 rectal swab samples from apparently healthy bats (n = 96), pigs (n = 9), cattles (n = 9), stray d...

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Plos One : Physicians Infrequently Adhere to Hepatitis Vaccination...

By: John E. Tavis

Description : Hepatitis vaccination rates were suboptimal even in an academic, sub-speciality setting, with wide-variability in provider adherence to vaccination guidelines

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Plos One : the Glutathione Reductase Gsr-1 Determines Stress Toler...

By: C. Jill Bettinger

Description : Glutathione (GSH) and GSH-dependent enzymes play a key role in cellular detoxification processes that enable organism to cope with various internal and environmental stressors. However, it is often not clear, which components of the complex GSH-metabolism are required for tolerance towards a certain stressor. To address this question, a small scale RNAi-screen was carried out in Caenorhabditis elegans where GSH-related genes were systematically knocked down...

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Plos One : Validation of Drug-like Inhibitors Against Mycobacteriu...

By: Daniel S. Sem

Description : The catalytic activity of L-aspartate a-decarboxylase (ADC) is essential for the growth of several micro-organisms, including Mycobacterium tuberculosis (Mtb), and has triggered efforts for the development of pharmaceutically active compounds against tuberculosis. The present study is a continuation of our recent chemoinformatics-based design approach for identifying potential drug-like inhibitors against MtbADC. We report an NMR-based protocol that allows ...

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Plos One : Janus Kinase 2 Polymorphisms Are Associated with Risk i...

By: Hiromu Suzuki

Description : The JAK2 gene rs2230724 and rs1887427 polymorphisms are associated with an increased risk of gastric cancer in a Chinese Han population.

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Plos One : an O Island 172 Encoded Rna Helicase Regulates the Moti...

By: A. Mark Ibekwe

Description : Enterohaemorrhagic Escherichia coli (EHEC) O157:H7 is a major cause of zoonotic food- and water-borne intestinal infections worldwide with clinical consequences ranging from mild diarrhoea to hemolytic uraemic syndrome. The genome of EHEC O157:H7 contains many regions of unique DNA that are referred to as O islands including the Shiga toxin prophages and pathogenicity islands encoding key virulence factors. However many of these O islands are of unknown fun...

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Plos One : a Duplex Pcr-based Assay for Measuring the Amount of Ba...

By: Dipankar Chatterji

Description : The assay protocol we describe here is a simple and relatively inexpensive method of measuring contamination levels in nucleic acid samples. This provides a new way to establish quantification and purification protocols for molecular biology and genomics in novel heterotrophic protist species. Guidelines are provided to develop a similar protocol for use with any protistan culture. This assay method is recommended where qPCR equipment is unavailable, where ...

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Plos One : Clinical and Biological Relevance of Genomic Heterogene...

By: Kristy L. Richards

Description : Our results indicate that investigations focusing on small numbers of patient samples likely provide a biased outlook on CLL biology. These findings may have important implications in identifying patients who should be treated with specific targeted therapies, which could have efficacy against CLL cells that rely on specific biological pathways.

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Plos One : Comparative Physiology of Oleaginous Species from the Y...

By: Steven Harris

Description : Yarrowia lipolytica is a genetically tractable yeast species that has become an attractive model for analyses of lipid metabolism, due to its oleaginous nature. We investigated the regulation and evolution of lipid metabolism in non- Saccharomycetaceae yeasts, by carrying out a comparative physiological analysis of eight species recently assigned to the Yarrowia clade : Candida alimentaria, Y. deformans, C. galli, C. hispaniensis, C. hollandica, C. oslonens...

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Plos One : Plasmodium Berghei Dp52&P36Parasites Develop Independen...

By: Stefan Kappe

Description : The proteins P52 and P36 are expressed in the sporozoite stage of the murine malaria parasite Plasmodium berghei. Dp52&p36 sporozoites lacking expression of both proteins are severely compromised in their capability to develop into liver stage parasites and abort development soon after invasion: presumably due to the absence of a parasitophorous vacuole membrane (PVM). However, a small proportion of P. berghei Dp52&p36 parasites is capable to fully mature i...

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Plos One : Five Different Piscidins from Nile Tilapia, Oreochromis...

By: Chandra Verma

Description : Piscidins are antimicrobial peptides (AMPs) that play important roles in helping fish resist pathogenic infections. Through comparisons of tilapia EST clones, the coding sequences of five piscidin-like AMPs (named TP1,5) of Nile tilapia, Oreochromis niloticus, were determined. The complete piscidin coding sequences of TP1, -2, -3, -4, and -5 were respectively composed of 207, 234, 231, 270, and 195 bases, and each contained a translated region of 68, 77, 76...

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