World Library  


 
  • Cover Image

Plos One : Modeling of Tumor Progression in Nsclc and Intrinsic Re...

By: Hassan Ashktorab

Description : EGFR signaling plays a very important role in NSCLC. It activates Ras/ERK, PI3K/Akt and STAT activation pathways. These are the main pathways for cell proliferation and survival. We have developed two mathematical models to relate to the different EGFR signaling in NSCLC and normal cells in the presence or absence of EGFR and PTEN mutations. The dynamics of downstream signaling pathways vary in the disease state and activation of some factors can be indicat...

Read More
  • Cover Image

Plos One : Caregivers in China ; Knowledge of Mild Cognitive Impai...

By: Jerson Laks

Description : This study aimed to examine the experience and knowledge of mild cognitive impairment (MCI) among Chinese family caregivers of individuals with MCI. The sample was recruited from memory clinics in Zhongnan Hospital in Wuhan, China. Indepth semi-structured interviews were used. Thirteen family members of individuals diagnosed with MCI participated in the study. Data analysis revealed three themes : 1) initial recognition of cognitive decline: 2) experience o...

Read More
  • Cover Image

Plos One : Interactions Between the R2R3-myb Transcription Factor,...

By: Turgay Unver

Description : Despite the prominent roles played by R2R3-MYB transcription factors in the regulation of plant gene expression, little is known about the details of how these proteins interact with their DNA targets. For example, while Arabidopsis thaliana R2R3-MYB protein AtMYB61 is known to alter transcript abundance of a specific set of target genes, little is known about the specific DNA sequences to which AtMYB61 binds. To address this gap in knowledge, DNA sequences...

Read More
  • Cover Image

Plos One : Maternal Deprivation Enhances Behavioral Vulnerability ...

By: Judith Homberg

Description : These results suggest that MD enhances behavioral vulnerability to stress during adulthood, which is associated with the upregulation of miR-504 and downregulation of DRD2 expression in the nucleus accumbens.

Read More
  • Cover Image

Plos One : Hepatocyte Growth Factor Activator Inhibitor-1 is Induc...

By: Debra L. Silver

Description : This study shows that the cell-surface serine protease inhibitors, HAI-1 and HAI-2 influence proliferation and cell fate of NPCs and their expression levels are linked to BMP signaling. Modulation of the levels and actions of HAI-1 in NPCs may be of a potential value in stem cell therapies in various brain diseases.

Read More
  • Cover Image

Plos One : Galectin-3 Functions as an Alarmin ; Pathogenic Role fo...

By: Carlos Jose Alves-filho

Description : Sepsis is a complex immune disorder with a mortality rate of 20–50% and currently has no therapeutic interventions. It is thus critical to identify and characterize molecules/factors responsible for its development. We have recently shown that pulmonary infection with Francisella results in sepsis development. As extensive cell death is a prominent feature of sepsis, we hypothesized that host endogenous molecules called alarmins released from dead or dying ...

Read More
  • Cover Image

Plos One : the Spectrum of Podoplanin Expression in Encapsulating ...

By: Mitsunobu R. Kano

Description : Encapsulating peritoneal sclerosis (EPS) is a life threatening complication of peritoneal dialysis (PD). Podoplanin is a glycoprotein expressed by mesothelial cells, lymphatic endothelial cells, and myofibroblasts in peritoneal biopsies from patients with EPS. To evaluate podoplanin as a marker of EPS we measured podoplanin mRNA and described the morphological patterns of podoplanin-positive cells in EPS. Included were 20 peritoneal biopsies from patients w...

Read More
  • Cover Image

Plos One : Mhc Class I-presented T Cell Epitopes Identified by Imm...

By: Geetha P. Bansal

Description : Influenza virus infection and the resulting complications are a significant global public health problem. Improving humoral immunity to influenza is the target of current conventional influenza vaccines, however, these are generally not crossprotective. On the contrary, cell-mediated immunity generated by primary influenza infection provides substantial protection against serologically distinct viruses due to recognition of cross-reactive T cell epitopes, o...

Read More
  • Cover Image

Plos One : Mesenchymal Stem Cells Develop Tumor Tropism but Do Not...

By: Yi Li

Description : The role of mesenchymal stem cells (MSCs) on breast cancer progression, growth and tumorigenesis remains controversial or unknown. In the present study, we investigated the role of MSCs on breast tumor induction and growth in a clinically relevant somatic breast cancer model. We first conducted in vitro studies and found that conditioned media (CM) of RCASNeu and RCAS-PyMT breast cancer cell lines and tumor cells themselves dramatically increased the prolif...

Read More
  • Cover Image

Plos One : Vascular Dysfunction Following Polymicrobial Sepsis ; R...

By: Jose Carlos Alves-filho

Description : Within our model, CD14 and TLR9 play a decisive role for the development of vascular dysfunction and thus can be effectively antagonized using H154-ODN. TLR2-D animals are more prone to polymicrobial sepsis, presumably due to up-regulation of TLR4, 9 and CD14.

Read More
  • Cover Image

Plos One : Respiratory Syncytial Virus Reverses Airway Hyperrespon...

By: Maria Leite De Moraes

Description : Each year, approximately 20% of asthmatics in the United States experience acute symptom exacerbations, which commonly result from pulmonary viral infections. The majority of asthma exacerbations in very young children follow infection with respiratory syncytial virus (RSV). However, pathogenic mechanisms underlying induction of asthma exacerbations by RSV are not well understood. We therefore investigated the effect of post-sensitization RSV infection on l...

Read More
  • Cover Image

Plos One : Interactogeneous ; Disease Gene Prioritization Using He...

By: Paolo Provero

Description : Disease gene prioritization aims to suggest potential implications of genes in disease susceptibility. Often accomplished in a guilt-by-association scheme, promising candidates are sorted according to their relatedness to known disease genes. Network-based methods have been successfully exploiting this concept by capturing the interaction of genes or proteins into a score. Nonetheless, most current approaches yield at least some of the following limitations...

Read More
  • Cover Image

Plos One : Explicit Mentalizing Mechanisms and Their Adaptive Role...

By: Mitsunobu R. Kano

Description : Memory conformity occurs when an individual endorses what other individuals remember about past events. Research on memory conformity is currently dominated by a ‘forensic’ perspective, which views the phenomenon as inherently undesirable. This is because conformity not only distorts the accuracy of an individual’s memory, but also produces false corroboration between individuals, effects that act to undermine criminal justice systems. There is growing awar...

Read More
  • Cover Image

Plos One : Does Changing Androgen Receptor Status During Prostate ...

By: Antimo Migliaccio

Description : Overall cholesterol homeostasis is unaffected by changing androgen receptor activity in prostate cancer cells. This does not negate the relationship between androgens and cholesterol homeostasis, but rather suggests that other factors compensate for altered androgen receptor activity. Given that cholesterol regulation is maintained during progression, this supports the growing idea that cholesterol metabolism is a suitable target for prostate cancer.

Read More
  • Cover Image

Plos One : Dna Vaccination Partially Protects Against African Swin...

By: Elankumaran Subbiah

Description : The lack of available vaccines against African swine fever virus (ASFV) means that the evaluation of new immunization strategies is required. Here we show that fusion of the extracellular domain of the ASFV Hemagglutinin (sHA) to p54 and p30, two immunodominant structural viral antigens, exponentially improved both the humoral and the cellular responses induced in pigs after DNA immunization. However, immunization with the resulting plasmid (pCMV-sHAPQ) did...

Read More
  • Cover Image

Plos One : Intelligently Targeted Drug Delivery and Enhanced Antit...

By: Ramon Andrade De Mello

Description : The results in this study preliminarily demonstrated the effectiveness of gelatinase-responsive targeting strategy and the prospect of this intelligent nano-drug delivery system though further studies are needed.

Read More
  • Cover Image

Plos One : Amino Acid Usage is Asymmetrically Biased in At- and Gc...

By: Tamir Tuller

Description : Genomic base composition has a substantial effect on both amino acid- and codon frequencies in bacterial genomes. While phylogeny influenced amino acid usage more in GC-rich genomes, AT-content was driving amino acid usage in AT-rich genomes. We found the GAMM model to be an excellent tool to analyze the genomic data used in this study.

Read More
  • Cover Image

Plos One : Combined Enzymatic and Physical Deinking Methodology fo...

By: Pratul K. Agarwal

Description : This is the first report on deinking of ONP with laccase without any mediator supplementation. XL pretreatment resulted in marked improvement in paper quality and a new sequence being reported for deinking (S-MW-XL) will contribute further in decreasing chemical consumption and making the process commercially feasible.

Read More
  • Cover Image

Plos One : Graptopetalum Paraguayense Ameliorates Chemical- Induce...

By: David L. McCormick

Description : The results show that the administration of MGP attenuated toxin-induced hepatic damage and fibrosis in vivo and inhibited HSC and Kupffer cell activation in vitro, suggesting that MGP might be a promising complementary or alternative therapeutic agent for liver inflammation and fibrosis.

Read More
  • Cover Image

Plos One : Early Detection of Lewis Lung Carcinoma Tumor Control b...

By: Ching-po Lin

Description : Early increase in ADC and ve correlated with tumor control by irradiation

Read More
 
1
|
2
|
3
Records: 1 - 20 of 45 - Pages: 



Copyright © World Library Foundation. All rights reserved. eBooks from World Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.