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Plos One : Transcriptome Analysis of Newt Lens Regeneration Reveal...

By: Xin Zhang

Description : Regeneration of the lens in newts is quite a unique process. The lens is removed in its entirety and regeneration ensues from the pigment epithelial cells of the dorsal iris via transdifferentiation. The same type of cells from the ventral iris are not capable of regenerating a lens. It is, thus, expected that differences between dorsal and ventral iris during the process of regeneration might provide important clues pertaining to the mechanism of regenerat...

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Plos One : Simple Spion Incubation as an Efficient Intracellular L...

By: Aditya Bhushan Pant

Description : Cellular magnetic resonance imaging (MRI) has been well-established for tracking neural progenitor cells (NPC). Superparamagnetic iron oxide nanoparticles (SPIONs) approved for clinical application are the most common agents used for labeling. Conventionally, transfection agents (TAs) were added with SPIONs to facilitate cell labeling because SPIONs in the native unmodified form were deemed inefficient for intracellular labeling. However, compelling evidenc...

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Plos One : Temporal Expression and Localization Patterns of Varian...

By: Lars Hviid

Description : Avoidance of antibody-mediated immune recognition allows parasites to establish chronic infections and enhances opportunities for transmission. The human malaria parasite Plasmodium falciparum possesses a number of multi-copy gene families, including var, rif, stevor and pfmc-2tm, which encode variant antigens believed to be expressed on the surfaces of infected erythrocytes. However, most studies of these antigens are based on in vitro analyses of culture-...

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Plos One : Vitamin D Receptor Gene and Aggrecan Gene Polymorphisms...

By: Hoong-chien Lee

Description : This meta-analysis suggested that the alleles with shorter VNTR length significantly increased the risk of IDD, while the VDR (TaqI, FokI, ApaI) gene polymorphisms were not significantly associated with the risk of IDD. Since potential confounders could not be ruled out completely, further studies are needed to confirm these results.

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Plos One : Β-catenin is Essential for Efficient in Vitro Premyogen...

By: Atsushi Asakura

Description : Previous studies have shown that P19 cells expressing a dominant negative b-catenin mutant (b-cat/EnR) cannot undergo myogenic differentiation in the presence or absence of muscle-inducing levels of retinoic acid (RA). While RA could upregulate premyogenic mesoderm expression, including Pax3/7 and Meox1, only Pax3/7 and Gli2 could be upregulated by RA in the presence of b-cat/EnR. However, the use of a dominant negative construct that cannot be compensated ...

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Plos One : Targeted Anp32E Mutant Mice Do Not Demonstrate Obvious ...

By: Alfred Lewin

Description : Since it is unlikely that the gene-trap is a more complete loss-of-function, our results suggest that ANP32E has no appreciable effect on motor functions and that genetic background differences most likely account for the gene-trap phenomena.

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Plos One : Foxa1 and Foxa2 Are Required for Formation of the Inter...

By: Xin Zhang

Description : The intervertebral disc (IVD) is composed of 3 main structures, the collagenous annulus fibrosus (AF), which surrounds the gel-like nucleus pulposus (NP), and hyaline cartilage endplates, which are attached to the vertebral bodies. An IVD is located between each vertebral body. Degeneration of the IVD is thought to be a major cause of back pain, a potentially chronic condition for which there exist few effective treatments. The NP forms from the embryonic n...

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Plos One : Application of a Qpcr Assay in the Investigation of Sus...

By: Georges Snounou

Description : Plasmodium falciparum is the causative agent of malaria, a disease that kills almost one million persons each year, mainly in sub-Saharan Africa. P. falciparum is transmitted to the human host by the bite of an Anopheles female mosquito, and Anopheles gambiae sensus stricto is the most tremendous malaria vector in Africa, widespread throughout the afro-tropical belt. An. gambiae s.s. is subdivided into two distinct molecular forms, namely M and S forms. The...

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Plos One : Multiple-clone Activation of Hypnozoites is the Leading...

By: Mauricio Martins Rodrigues

Description : The high rate of low frequency alleles observed in both primary and relapse infections, along with temporal variation in the predominant alleles, might be the source of reported heterologous hypnozoite activation. Our findings complicate the concept of heterologous activation, suggesting the involvement of undetermined mechanisms based on host or environmental factors in the simultaneous activation of multiple clones of hypnozoites.

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Plos One : the Proximate Phonological Unit of Chinese-english Blil...

By: Kevin Paterson

Description : An essential step to create phonology according to the language produciton model by levelet, roelofs amd meyer is to assemble phonomes into a metrical frame.

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Plos One : Lower Cerebrospinal Fluid, Volume 8

By: Victor Sanchez-margalet

Description : The central actions of FGF21 in GDM subjects maybe pivotal in the pathogenesis of insulin resistance in GDM subjects. The significance of FGF21 produced by the placenta remains uncharted and maybe crucial in our understanding of the patho-physiology of GDM and its associated maternal and fetal complications. Future research should seek to elucidate these points.

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Plos One : Novel Reassortant Highly Pathogenic H5N2 Avian Influenz...

By: Todd Davis

Description : There has been multiple evidence that domestic poultry may act as a vessel for the generation of novel influenza A viruses. In this study, we have analyzed the evolution and pathogenicity of 4 H5N2 avian influenza viruses isolated from apparently healthy poultry from H5N1 virus endemic areas in China. Phylogenetic analysis revealed that two of these viruses, A/duck/ Eastern China/1111/2011 (DK/EC/1111/11) and A/goose/Eastern China/1112/2011 (GS/EC/1112/11) ...

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Plos One : Assessing Spatial Accessibility to Maternity Units in S...

By: Josef Neu

Description : Results of this study suggest a great effort should be made to improve the equity of spatial accessibility to MUs in Shenzhen. For policy-making, strategy for the siting and allocation of future MUs, no matter public or private, should guarantee the greatest spatial accessibility for every pregnant woman.

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Plos One : Endocytic Mechanism of Internalization of Dietary Pepti...

By: Christian Schulz

Description : Cardiovascular disease (CVD) is the leading cause of death in the United States. Diet influences risk factors associated with CVD and atherosclerosis, a major vascular disease that arises from inflammation. Lunasin, a peptide derived from plant foods such as soybeans, contains a unique Arg-Gly-Asp cell-adhesion motif and inhibits the pathways involved in the inflammatory cascade. The objective was to determine the mechanism by which lunasin is internalized ...

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Plos One : Polypyrimidine Tract Binding Protein-1 Ptb1 is a Determ...

By: Dong-yan Jin

Description : The internal ribosomal entry site (IRES) of picornavirus genomes serves as the nucleation site of a highly structured ribonucleoprotein complex essential to the binding of the 40S ribosomal subunit and initiation of viral protein translation. The transition from naked RNA to a functional IRESome complex are poorly understood, involving the folding of secondary and tertiary RNA structure, facilitated by a tightly concerted binding of various host cell protei...

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Plos One : an Algorithm to Automate Yeast Segmentation and Trackin...

By: Michael Polymenis

Description : Our understanding of dynamic cellular processes has been greatly enhanced by rapid advances in quantitative fluorescence microscopy. Imaging single cells has emphasized the prevalence of phenomena that can be difficult to infer from population measurements, such as all-or-none cellular decisions, cell-to-cell variability, and oscillations. Examination of these phenomena requires segmenting and tracking individual cells over long periods of time. However, ac...

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Plos One : Agp2, a Member of the Yeast Amino Acid Permease Family,...

By: Raymund J. Wellinger

Description : Agp2 is a plasma membrane protein of the Saccharomyces cerevisiae amino acid transporter family, involved in high-affinity uptake of various substrates including L-carnitine and polyamines. The discovery of two high affinity polyamine permeases, Dur3 and Sam3, prompted us to investigate whether Agp2 directly transports polyamines or acts instead as a regulator. Herein, we show that neither dur3D nor sam3D single mutant is defective in polyamine transport, w...

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Plos One : Antepartum Depression and Anxiety Associated with Disab...

By: James Bennett Potash

Description : Antepartum depression and anxiety were highly prevalent in our sample and contributed substantially to perceived disability. These serious threats to health must be further investigated and more data are needed to comprehensively quantify the problem in sub-Saharan Africa

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Plos One : Perinatal Clinical Antecedents of White Matter Microstr...

By: Wang Zhan

Description : Diffusion tensor imaging is sensitive in detecting the widespread cerebral delayed maturation and/or damage increasingly observed in extremely preterm infants. In our cohort, it also aided identification of several previously known or suspected perinatal clinical antecedents of brain injury, aberrant development, and neurodevelopmental impairments

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Plos One : Consequences of Repeated Blood-brain Barrier Disruption...

By: Krishnan M. Dhandapani

Description : The acknowledgement of risks for traumatic brain injury in American football players has prompted studies for sideline concussion diagnosis and testing for neurological deficits. While concussions are recognized etiological factors for a spectrum of neurological sequelae, the consequences of sub-concussive events are unclear. We tested the hypothesis that blood-brain barrier disruption (BBBD) and the accompanying surge of the astrocytic protein S100B in blo...

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