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Use of Haploid Plants as Bioassays for - Mutagens

By Christianson, M. L.

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Book Id: WPLBN0000000378
Format Type: PDF eBook
File Size: 0.4 MB
Reproduction Date: 2005

Title: Use of Haploid Plants as Bioassays for - Mutagens  
Author: Christianson, M. L.
Volume:
Language: English
Subject: Government publications, United Nations., United Nations. Office for Disarmament Affairs
Collections: Government Library Collection, Disarmament Documents
Historic
Publication Date:
Publisher: United Nations- Office for Disarmament Affairs (Unoda)

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Christianson, M. L. (n.d.). Use of Haploid Plants as Bioassays for - Mutagens. Retrieved from http://netlibrary.net/


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Government Reference Publication

Excerpt
Introduction: Mutagenic agents typically effect several mutational processes. In mouse erythoblasts, for example, a known bacterial frame-shift mutagen produces chromosome fragments (I) . Most bioassays for mutagenic activity by use of higher plants simply measure the total number of mutations; the partitioning of this quantitative measurement into categories-sectors due to deletion, due to point mutation, due to gene conversion, and so on-is not, and usually could not, be done. This lack of qualitative characterization severely limits the depth of comparisons of different mutagens or even the evaluation of a single mutagen at different doses. Two mutagens, or doses of one mutagen, could give the same total number of mutations in a bioassay system. One mutagen or dose might cause mainly deletions while the other mutagen or dose might cause primarily point mutations. In another biological system, the relative mutagenicity of those two agents or doses will be the same only if the biological system allows for both types of mutations, and at the same sensitivity as the first assay system.

 

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