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Distribution of Methyl Sulfone Metabolites of Polychlorinated Biphenyls and P. P-Dde in Human Tissues

By Chu, Shaogang

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Book Id: WPLBN0000000383
Format Type: PDF eBook
File Size: 0.2 MB
Reproduction Date: 2005
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Title: Distribution of Methyl Sulfone Metabolites of Polychlorinated Biphenyls and P. P-Dde in Human Tissues  
Author: Chu, Shaogang
Language: English
Subject: Government publications, United Nations., United Nations. Office for Disarmament Affairs
Collections: Government Library Collection, Disarmament Documents
Publication Date:
Publisher: United Nations- Office for Disarmament Affairs (Unoda)


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Chu, S. (n.d.). Distribution of Methyl Sulfone Metabolites of Polychlorinated Biphenyls and P. P-Dde in Human Tissues. Retrieved from

Government Reference Publication

Excerpt: We determined methylsulfonyl metabolites of chlorinated biphenyls (MeSO2-CBs) and 1,1-bis(4- chlorophenyl)-2,2-dichloroethene (p,p-DDE) in human adipose, liver, brain, and lung tissues obtained from 11 Belgian individuals (9?62 years of age). The total concentration of MeSO2-CBs (lipid weight basis) decreased in the following order: liver (mean, 9.30 ng/g; range, 1.68?27.03 ng/g lipid) > lung [mean, 2.72 ng/g; range, not detected (ND) to 11.54 ng/g lipid] > adipose tissue (mean, 1.57 ng/g; range, 0.33?4.33 ng/g lipid) > brain (mean, 0.24 ng/g; range, ND?0.56 ng/g lipid). The profiles of MeSO2-CBs and MeSO2-DDE in each tissue were similar for all 11 subjects. In adipose, brain, and lung tissues, 4-MeSO2-CB87, 4-MeSO2-CB101, and 3-MeSO2-CB149 (except brain) occurred at higher concentrations than did other MeSO2-CBs. However, 3-MeSO2- CB132 was by far the most abundant congener in liver, contributing on average to approximately 60% of the sum of MeSO2-CBs. The concentrations of 3-MeSO2-DDE in different tissues were at the same or lower levels than the total concentrations of MeSO2-CBs. This study suggests that the distribution patterns of MeSO2-CBs and MeSO2-DDE in humans differ between liver and other tissues. Moreover, these profiles differ from those found in other mammals, such as polar bears, porpoises, and otters. Key words: adipose tissue, brain, DDE, humans, liver, lung, methyl sulfone, PCBs.


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