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Cancer Mortality and Environmental Exposure to Dde in the United States

By Cocco, Pierluigi

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Book Id: WPLBN0000002655
Format Type: PDF eBook
File Size: 0.2 MB
Reproduction Date: 2005
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Title: Cancer Mortality and Environmental Exposure to Dde in the United States  
Author: Cocco, Pierluigi
Language: English
Subject: Government publications, United Nations., United Nations. Office for Disarmament Affairs
Collections: Government Library Collection, Disarmament Documents
Publication Date:
Publisher: United Nations- Office for Disarmament Affairs (Unoda)


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Cocco, P. (n.d.). Cancer Mortality and Environmental Exposure to Dde in the United States. Retrieved from

Government Reference Publication

Excerpt: Agricultural use of the insecticide DDT was banned in 1973 in the United States and in most Western countries. However, some Eastern European countries and numerous developing countries still use DDT, primarily in the prevention of malaria, typhus, yellow fever, and sleeping sickness (1). The current industrial production of DDT is only a small fraction of the 80,000 tons produced in 1963. However, concern exists over possible health consequences of its indiscriminate use in the past because of its prolonged half-life and biologic persistence, which may extend over several decades, particularly in temperate climates (1). The ability of the prevalent isomer of the major and most persistent DDT derivative, p,p-dichlorodiphenyldichloroethylene (p,p-DDE), to bind to the androgen receptor in male rats has been reported (2). In 1991, the International Agency for Research on Cancer evaluated the evidence of DDT carcinogenicity as sufficient in experimental animals (1). Subcutaneous injection and oral administration of DDT and its metabolites such as DDE and dichlorodiphenyldichloroethane were followed by a dose-related increase of liver tumors in mice and rats. Results were less consistent for malignant lymphomas, lung carcinomas, and thyroid tumors (1).


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