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Detection of Polycyclic Aromatic Hydrocarbon-Dna Adducts in Human Lung

By Weston, Ainsley

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Book Id: WPLBN0000027374
Format Type: PDF eBook
File Size: 0.2 MB
Reproduction Date: 2005

Title: Detection of Polycyclic Aromatic Hydrocarbon-Dna Adducts in Human Lung  
Author: Weston, Ainsley
Language: English
Subject: Government publications, United Nations., United Nations. Office for Disarmament Affairs
Collections: Government Library Collection, Disarmament Documents
Publication Date:
Publisher: United Nations- Office for Disarmament Affairs (Unoda)


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Weston, A. (n.d.). Detection of Polycyclic Aromatic Hydrocarbon-Dna Adducts in Human Lung. Retrieved from

Government Reference Publication

Introduction: Polyclicar omatic hydrocarbons (PAHs) form a major class of enirbnmental pollu&ts; many of these compounds can be metabolized and activated to carcinogenic species that bind covalently with DNA (I) . To measure genotoxic damage from PAHs, fluorescence techniques have been developed for the detection of DNA adducts, and r-7,t-8-dihydroxy-I-9,lO-epoxy- 7,8,9,lO-tetrahydrobenzo[a]pyrene (BPDE)-DNA adducts have been identified in human tissues (2). Our strategy for detection and chemical characterization of adducts is based on combining the following preparative and analytical procedures: irnmunoaffinity chromatography is used to concentrate adducts of a specific chemical class (PAHs); HPLC facilitates separation of DNA hydrolysis products; and synchronous fluorescence spectroscopy (SFS), second derivative synchronous fluorescence spectroscopy, and the generation of fluorescence excitation-emission matrices (FEEMs) provide chemically specific detection systems. Using this strategy (3,4),le vels of BPDE-DNA adducts.


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