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Loud Noise Is Generally Considered an Environmental Stressor Causing Negative Effects on Acoustic, Cardiovascular, Nervous, And Endocrine Systems. In This Study, We Investigated the Effects of Noise Exposure on Dna Integrity in Rat Adrenal Gland Evaluated by the Comet Assay. The Exposure to Loud Noise (100 Dba) for 12 Hr Caused a Significant Increase of Dna Damage in the Adrenal Gland. Genetic Alterations Did Not Decrease 24 Hr after the Cessation of the Stimulus. We Hypothesize That an Imbalance of Redox Cell Status Is Responsible for the Induction and Persistence of Noise-Induced Cellular Damage. Key Words : Adrenal Gland, Comet Assay, Dna Damage, Loud Noise, Rat. Environ Health Perspect 112: 16711672 (2004). Doi: 10. 1289/Ehp. 7249 Available Via Http: //Dx. Doi. Org/ (Online 22 September 2004)

By Frenzilli, Giada

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Book Id: WPLBN0000046136
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Title: Loud Noise Is Generally Considered an Environmental Stressor Causing Negative Effects on Acoustic, Cardiovascular, Nervous, And Endocrine Systems. In This Study, We Investigated the Effects of Noise Exposure on Dna Integrity in Rat Adrenal Gland Evaluated by the Comet Assay. The Exposure to Loud Noise (100 Dba) for 12 Hr Caused a Significant Increase of Dna Damage in the Adrenal Gland. Genetic Alterations Did Not Decrease 24 Hr after the Cessation of the Stimulus. We Hypothesize That an Imbalance of Redox Cell Status Is Responsible for the Induction and Persistence of Noise-Induced Cellular Damage. Key Words : Adrenal Gland, Comet Assay, Dna Damage, Loud Noise, Rat. Environ Health Perspect 112: 16711672 (2004). Doi: 10. 1289/Ehp. 7249 Available Via Http: //Dx. Doi. Org/ (Online 22 September 2004)  
Author: Frenzilli, Giada
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Language: English
Subject: Government publications, United Nations., United Nations. Office for Disarmament Affairs
Collections: Government Library Collection, Disarmament Documents
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Publisher: United Nations- Office for Disarmament Affairs (Unoda)

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Frenzilli, G. (n.d.). Loud Noise Is Generally Considered an Environmental Stressor Causing Negative Effects on Acoustic, Cardiovascular, Nervous, And Endocrine Systems. In This Study, We Investigated the Effects of Noise Exposure on Dna Integrity in Rat Adrenal Gland Evaluated by the Comet Assay. The Exposure to Loud Noise (100 Dba) for 12 Hr Caused a Significant Increase of Dna Damage in the Adrenal Gland. Genetic Alterations Did Not Decrease 24 Hr after the Cessation of the Stimulus. We Hypothesize That an Imbalance of Redox Cell Status Is Responsible for the Induction and Persistence of Noise-Induced Cellular Damage. Key Words : Adrenal Gland, Comet Assay, Dna Damage, Loud Noise, Rat. Environ Health Perspect 112: 16711672 (2004). Doi: 10. 1289/Ehp. 7249 Available Via Http: //Dx. Doi. Org/ (Online 22 September 2004). Retrieved from http://netlibrary.net/


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Government Reference Publication

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Excerpt: During daily life, people are exposed to potentially hazardous noise levels related to work environment, urban traffic, household appliances, discos, and the like (Kawecka- Jaszcz 1991; Lang et al. 1992). The World Health Organization (Berglund et al. 1999) estimated that approximately 20% of the European population is exposed to noise generated by urban traffic > 65 dBA, a level regarded as a maximum safety threshold, whereas 40% of Europeans are exposed to noise levels between 55 and 65 dBA, which might be responsible for several disorders of both auditory and extra-auditory organs (Berglund et al. 1999). Extraauditory effects of noise have been related to psychophysiologic stress and the involvement of the pituitary?adrenocortical axis (Axelrod and Reisine 1984; Ising and Braun 2000). Most studies on the effects of noise exposure on the hypothalamus? pituitary?adrenocortical axis have been performed by measuring behavioral, endocrine, and biochemical variables (Alario et al. 1987; Armario et al. 1984; Borrell et al. 1980), whereas few studies have investigated the cellular effects induced by exposure to noise stress. Among these, Pellegrini et al. (1997) and Soldani et al. (1999) demonstrated the occurrence of ultrastructural modifications in the adrenal gland of noise exposed rats. Moreover, recent findings showed that ultrastructural alterations in the rat myocardium detected after loud noise exposure were also accompanied by DNA damage (Lenzi et al. 2003).

 

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