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Preferential Dna Repair in Expressed Genes

By Hanawalt, Philip C.

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Book Id: WPLBN0000066365
Format Type: PDF eBook
File Size: 0.6 MB
Reproduction Date: 2005

Title: Preferential Dna Repair in Expressed Genes  
Author: Hanawalt, Philip C.
Language: English
Subject: Government publications, United Nations., United Nations. Office for Disarmament Affairs
Collections: Government Library Collection, Disarmament Documents
Publication Date:
Publisher: United Nations- Office for Disarmament Affairs (Unoda)


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Hanawalt, P. C. (n.d.). Preferential Dna Repair in Expressed Genes. Retrieved from

Government Reference Publication

Excerpt: In studying the complex relationships between the repair of damaged DNA in mammalian cells and biological end points such as survival, mutagenesis, and transformation, the repair proficiency has usually been assumed to be uniform throughout the genome and even within cell populations. However, we now know that DNA damage in some regions of the genome is processed much more efficiently than that in others (1,2). Heterogeneity in repair would result in corresponding differences in the responses seen for particular biological effects, since the consequences of nnrepaired or misrepaired damage in DNA clearly depend upon the precise location of the damage with respect to the relevant domains in the genome.


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