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Development of a Health-Protective Drinking Water Level for Perchlorate

By Howd, Robert A.

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Book Id: WPLBN0000084365
Format Type: PDF eBook
File Size: 0.2 MB
Reproduction Date: 2005
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Title: Development of a Health-Protective Drinking Water Level for Perchlorate  
Author: Howd, Robert A.
Language: English
Subject: Government publications, United Nations., United Nations. Office for Disarmament Affairs
Collections: Government Library Collection, Disarmament Documents
Publication Date:
Publisher: United Nations- Office for Disarmament Affairs (Unoda)


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Howd, R. A. (n.d.). Development of a Health-Protective Drinking Water Level for Perchlorate. Retrieved from

Government Reference Publication

Excerpt: We evaluated animal and human toxicity data for perchlorate and identified reduction of thyroidal iodide uptake as the critical end point in the development of a health-protective drinking water level [also known as the public health goal (PHG)] for the chemical. This work was performed under the drinking water program of the Office of Environmental Health Hazard Assessment of the California Environmental Protection Agency. For dose?response characterization, we applied benchmark-dose modeling to human data and determined a point of departure (the 95% lower confidence limit for 5% inhibition of iodide uptake) of 0.0037 mg/kg/day. A PHG of 6 ppb was calculated by using an uncertainty factor of 10, a relative source contribution of 60%, and exposure assumptions specific to pregnant women. The California Department of Health Services will use the PHG, together with other considerations such as economic impact and engineering feasibility, to develop a California maximum contaminant level for perchlorate. We consider the PHG to be adequately protective of sensitive subpopulations, including pregnant women, their fetuses, infants, and people with hypothyroidism. Key words: drinking water level, human health, iodine intake, NIS, perchlorate, risk assessment, sensitive subpopulation, thyroid hormone.


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