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Development of Immunoassays for Biomonitoring of Hexamethylene Diisocyanate Exposure

By Lemus, Ranulfo

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Book Id: WPLBN0000122141
Format Type: PDF eBook
File Size: 0.6 MB
Reproduction Date: 2005
Full Text

Title: Development of Immunoassays for Biomonitoring of Hexamethylene Diisocyanate Exposure  
Author: Lemus, Ranulfo
Language: English
Subject: Government publications, United Nations., United Nations. Office for Disarmament Affairs
Collections: Government Library Collection, Disarmament Documents
Publication Date:
Publisher: United Nations- Office for Disarmament Affairs (Unoda)


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Lemus, R. (n.d.). Development of Immunoassays for Biomonitoring of Hexamethylene Diisocyanate Exposure. Retrieved from

Government Reference Publication

Excerpt: Isocyanates are highly reactive compounds used to manufacture polyurethanes. They account for the greatest number of reported cases of occupational asthma both in the United States and in other developed countries. Hexamethylene diisocyanate (HDI), one of the most commercially important isocyanates, is used as a polymerizing agent in polyurethane spray paint and coating formulations. Primary prevention of isocyanate asthma is problematic because industrial exposures are widespread and difficult to characterize, measure, and control. Secondary and tertiary prevention opportunities are limited because no simple way has been found to diagnose isocyanate asthma or identify specific at-risk groups. In addition, there is inadequate knowledge of isocyanate exposure patterns and the factors that both cause and exacerbate the disease. As a result of its reactivity and recognized toxicity, there is great interest in developing sensitive methods for detection of human exposure to HDI. Determination of HDI in the blood, serum, urine, and other body fluids is difficult because HDI not only is self-reactive buy may also hydrolyze or react readily with hydroxyl, sulfhydryl, or amino groups on proteins.


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