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Genotoxicity of 1, 4=Benzoquinone and 1, Cnaphthoquinone in Relation to Effects on Glutathione and Nad(P)H Levels in V79 Cells

By Ludewig, Gabriele

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Book Id: WPLBN0000130794
Format Type: PDF eBook
File Size: 0.4 MB
Reproduction Date: 2005

Title: Genotoxicity of 1, 4=Benzoquinone and 1, Cnaphthoquinone in Relation to Effects on Glutathione and Nad(P)H Levels in V79 Cells  
Author: Ludewig, Gabriele
Volume:
Language: English
Subject: Government publications, United Nations., United Nations. Office for Disarmament Affairs
Collections: Government Library Collection, Disarmament Documents
Historic
Publication Date:
Publisher: United Nations- Office for Disarmament Affairs (Unoda)

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Ludewig, G. (n.d.). Genotoxicity of 1, 4=Benzoquinone and 1, Cnaphthoquinone in Relation to Effects on Glutathione and Nad(P)H Levels in V79 Cells. Retrieved from http://netlibrary.net/


Description
Government Reference Publication

Excerpt
Excerpt: 1,4-Benzoquinone, a metabolite of benzene, is a potent mutagen in V79 Chinese hamster cells (1). The reason for this effect is not known, but it may involve one or several of the following mechanisms. Quinones are electrophiles and may undergo addition reactions with nucleophiles (Michael reaction). Indeed, when 1,4-benzoquinone was incubated in buffer with deoxyguanosine, adducts were formed (2). Alternative target stmctures are thiol groups and other nucleophilic moieties in proteins. Quinones may be metabolized to semiquinone free radicals, e.g., by oneelectron reduction or by two-electron reduction and subsequent one-electron oxidation (3). The resulting semiquinone radicals are chemically reactive and may react directly with the target structure in the cell. Alternatively, they may transfer their unpaired electron onto other molecules, e.g., onto molecular oxygen leading to superoxide, or onto superoxide leading to hydrogen.

 

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