World Library  


Add to Book Shelf
Flag as Inappropriate
Email this Book

Genetic Factors That Might Lead to Different Responses in Individuals Exposed to Perchlorate

By Murray, H, Edward

Click here to view

Book Id: WPLBN0000157841
Format Type: PDF eBook
File Size: 0.2 MB
Reproduction Date: 2005
Full Text

Title: Genetic Factors That Might Lead to Different Responses in Individuals Exposed to Perchlorate  
Author: Murray, H, Edward
Volume:
Language: English
Subject: Government publications, United Nations., United Nations. Office for Disarmament Affairs
Collections: Government Library Collection, Disarmament Documents
Historic
Publication Date:
Publisher: United Nations- Office for Disarmament Affairs (Unoda)

Citation

APA MLA Chicago

Murray, H. E. (n.d.). Genetic Factors That Might Lead to Different Responses in Individuals Exposed to Perchlorate. Retrieved from http://netlibrary.net/


Description
Government Reference Publication

Excerpt
Excerpt: Perchlorate has been detected in groundwater in many parts of the United States, and recent detection in vegetable and dairy food products indicates that contamination by perchlorate is more widespread than previously thought. Perchlorate is a competitive inhibitor of the sodium iodide symporter, the thyroid cell?surface protein responsible for transporting iodide from the plasma into the thyroid. An estimated 4.3% of the U.S. population is subclinically hypothyroid, and 6.9% of pregnant women may have low iodine intake. Congenital hypothyroidism affects 1 in 3,000 to 1 in 4,000 infants, and 15% of these cases have been attributed to genetic defects. Our objective in this review is to identify genetic biomarkers that would help define subpopulations sensitive to environmental perchlorate exposure. We review the literature to identify genetic defects involved in the iodination process of the thyroid hormone synthesis, particularly defects in iodide transport from circulation into the thyroid cell, defects in iodide transport from the thyroid cell to the follicular lumen (Pendred syndrome), and defects of iodide organification. Furthermore, we summarize relevant studies of perchlorate in humans. Because of perchlorate inhibition of iodide uptake, it is biologically plausible that chronic ingestion of perchlorate through contaminated sources may cause some degree of iodine discharge in populations that are genetically susceptible to defects in the iodination process of the thyroid hormone synthesis, thus deteriorating their conditions. We conclude that future studies linking human disease and environmental perchlorate exposure should consider the genetic makeup of the participants, actual perchlorate exposure levels, and individual iodine intake/excretion levels. Key words: genetic susceptibility, hypothyroidism, mutations, NIS, Pendred syndrome, pendrin, perchlorate, thyroid gland, TPO. Environ Health Perspect 113:1479?1484 (2005). doi:10.1289/ehp.8076 [29 June 200].

 

Click To View

Additional Books


  • Czechoslovak Stories (by )
  • Amusing Poetry, Ed. By S. Brooks (by )
  • The Harvard Classics : Volume 4 (by )
  • The Works of Edgar Allan Poe in Five Vol... (by )
  • The Harvard Classics : Volume 24 (by )
  • The Makropoulos Secret (by )
  • Strand Magazine : An Illustrated Monthly (by )
  • Rodney Stone (by )
  • Beyond the City (by )
  • Things as They Are (by )
  • Nuggets in the Devil's Punch Bowl, And O... (by )
  • Fiction but Not Falsehood (by )
Scroll Left
Scroll Right

 



Copyright © World Library Foundation. All rights reserved. eBooks from World Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.