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Introduction and Summary. International Workshop on Lead in Bone : Implications for Dosimetry and Toxicology

By Nordberg, Gunnar F.

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Book Id: WPLBN0000164745
Format Type: PDF eBook
File Size: 0.4 MB
Reproduction Date: 2005

Title: Introduction and Summary. International Workshop on Lead in Bone : Implications for Dosimetry and Toxicology  
Author: Nordberg, Gunnar F.
Volume:
Language: English
Subject: Government publications, United Nations., United Nations. Office for Disarmament Affairs
Collections: Government Library Collection, Disarmament Documents
Historic
Publication Date:
Publisher: United Nations- Office for Disarmament Affairs (Unoda)

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Nordberg, G. F. (n.d.). Introduction and Summary. International Workshop on Lead in Bone : Implications for Dosimetry and Toxicology. Retrieved from http://netlibrary.net/


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Government Reference Publication

Excerpt
Excerpt: Lead toxicity is a major public health problem in the United States. Recent statistics indicate that in the United States, between 3 and 4 million children ages 6 months to 5 years and approximately 400,000 infants in utero are exposed each year to lead in quantities associated with blood lead concentrations in excess of 15 gIdL whole blood. Blood lead concentrations chiefly reflect recent lead exposures. Lead is accumulated in the human skeleton, which is generally thought to provide an indicator of body burden of lead. Previous information based on chemical analyses of skeletal tissues indicate that among adults, over 95% of lead is in the skeleton. For children, approximately 70% of total body lead is present in osseous tissues. Since it is rarely possible to analyze either the total skeleton, or even an entire bone, biopsy techniques have been developed. Biopsies usually are accomplished by removing a small sample ofbone (for example, several hundred milligrams) from the skeleton and conducting chemical analyses for the material of interest, e.g., lead. A major question about biopsies is whether or not the sample taken is representative of the entire bone or skeleton. Techniques for measurement of lead in vivo have been developed to replace the invasive procedures used in bone biopsy and yet provide a measure of this body lead pool.

 

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