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Trichloroacetic Acid Effects on Rat Liver Peroxisomes and Enzyme-Altered Foci

By Parnell, Michael J.

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Book Id: WPLBN0000174311
Format Type: PDF eBook
File Size: 0.3 MB
Reproduction Date: 2005

Title: Trichloroacetic Acid Effects on Rat Liver Peroxisomes and Enzyme-Altered Foci  
Author: Parnell, Michael J.
Language: English
Subject: Government publications, United Nations., United Nations. Office for Disarmament Affairs
Collections: Government Library Collection, Disarmament Documents
Publication Date:
Publisher: United Nations- Office for Disarmament Affairs (Unoda)


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Parnell, M. J. (n.d.). Trichloroacetic Acid Effects on Rat Liver Peroxisomes and Enzyme-Altered Foci. Retrieved from

Government Reference Publication

Excerpt: The presence of trichloroacetic acid and other nonvolatile halogenated organic products of water chlorination in drinking water has only been recently recognized (1-6). Consequently, very few data are available concerning expected environmental levels or what, if any, adverse effects these chemical products may have on biological systems. Trichloroacetic acid (TCA), dichloroacetic acid (DCA), and chloral hydrate are major nonvolatile chlorinated products formed during chlorination of water containing organic material (1-5). What few data are available concerning levels of these compounds in finished drinking water indicate that their consistent presence ranges from ten to several hundred parts per billion (2,3). The environmental levels of these nonvolatile chlorination products will certainly vary with local conditions and are directly related to the concentration of humic materials present in the water (3,5). Enteric production of TCA and DCA following oral administration of sodium hypochlorite has also been demonstrated (7). Although TCA and DCA are structurally similar, chlorination studies of fulvic and humic acids indicate that TCA formation does not proceed through a DCA intermediate, hut that both form independently (3). The relative concentration of each depends on the reaction conditions (9,6).


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