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Relative Roles of Metabolism and Renal Excretory Mechanisms in Xenobiotic Elimination by Fish

By Pritchard, John B.

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Book Id: WPLBN0000189366
Format Type: PDF eBook
File Size: 0.5 MB
Reproduction Date: 2005

Title: Relative Roles of Metabolism and Renal Excretory Mechanisms in Xenobiotic Elimination by Fish  
Author: Pritchard, John B.
Volume:
Language: English
Subject: Government publications, United Nations., United Nations. Office for Disarmament Affairs
Collections: Government Library Collection, Disarmament Documents
Historic
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Publisher: United Nations- Office for Disarmament Affairs (Unoda)

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Pritchard, J. B. (n.d.). Relative Roles of Metabolism and Renal Excretory Mechanisms in Xenobiotic Elimination by Fish. Retrieved from http://netlibrary.net/


Description
Government Reference Publication

Excerpt
Introduction: Aquatic organisms are exposed to a wide variety of foreign chemicals. Many of these chemicals are potentially toxic to the organisms themselves and to other animals, including man, which may feed on them. Furthermore, once within the aquatic organism, a number of these chemicals, e.g., the polycyclic aromatic hydrocarbons (PAHs), may be converted to still more toxic forms through metabolic oxidation, usually via the cytochrome P-450 monooxygenase system (I). Therefore, the primary focus of much of the work in this area has been on mechiisms of metabolic activation and on the enzyme systems, e.e-... e . oxidhev drolase and the -el utathione transfetases. which mediate detoxication of the activated, chemically reactive metabolites (2.3).

 

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