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Within-Home Versus Between-Home Variability of House Dust Endotoxin in a Birth Cohort

By Abraham, Joseph H.

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Book Id: WPLBN0000198963
Format Type: PDF eBook
File Size: 0.2 MB
Reproduction Date: 2005
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Title: Within-Home Versus Between-Home Variability of House Dust Endotoxin in a Birth Cohort  
Author: Abraham, Joseph H.
Language: English
Subject: Government publications, United Nations., United Nations. Office for Disarmament Affairs
Collections: Government Library Collection, Disarmament Documents
Publication Date:
Publisher: United Nations- Office for Disarmament Affairs (Unoda)


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Abraham, J. H. (n.d.). Within-Home Versus Between-Home Variability of House Dust Endotoxin in a Birth Cohort. Retrieved from

Government Reference Publication

Excerpt: Endotoxin exposure has been proposed as an environmental determinant of allergen responses in children. To better understand the implications of using a single measurement of house dust endotoxin to characterize exposure in the first year of life, we evaluated room-specific within-home and between-home variability in dust endotoxin obtained from 470 households in Boston, Massachusetts. Homes were sampled up to two times over 5?11 months. We analyzed 1,287 dust samples from the kitchen, family room, and babys bedroom for endotoxin. We fit a mixed-effects model to estimate mean levels and the variation of endotoxin between homes, between rooms, and between sampling times. Endotoxin ranged from 2 to 1,945 units per milligram of dust. Levels were highest during summer and lowest in the winter. Mean endotoxin levels varied significantly from room to room. Cross-sectionally, endotoxin was moderately correlated between family room and bedroom floor (r = 0.30), between family room and kitchen (r = 0.32), and between kitchen and bedroom (r = 0.42). Adjusting for season, the correlation of endotoxin levels within homes over time was 0.65 for both the bedroom and kitchen and 0.54 for the family room. The temporal within-home variance of endotoxin was lowest for bedroom floor samples and highest for kitchen samples. Between-home variance was lowest in the family room and highest for kitchen samples. Adjusting for season, within-home variation was less than between-home variation for all three rooms. These results suggest that room-to-room and home-to-home differences in endotoxin influence the total variability more than factors affecting endotoxin levels within a room over time. Key words: dust endotoxin, endotoxin, intraclass correlation, variance components.


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